PMID- 32589931
OWN - NLM
STAT- MEDLINE
DCOM- 20201015
LR  - 20210202
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Print)
IS  - 0890-5096 (Linking)
VI  - 68
DP  - 2020 Oct
TI  - A Case of Covid-19 Patient with Acute Limb Ischemia and Heparin Resistance.
PG  - 88-92
LID - S0890-5096(20)30547-1 [pii]
LID - 10.1016/j.avsg.2020.06.046 [doi]
AB  - Heparin resistance is an uncommon phenomenon defined as the need for high-dose 
      unfractionated heparin (UFH) of more than 35,000 IU/day to achieve the target 
      activated partial-thromboplastin time ratio or the failure to achieve the desired 
      activated clotting time after a full UFH dose. This rare phenomenon is being more 
      commonly observed in Covid-19 patients in a hypercoagulable state. We describe a 
      Covid-19 patient confirmed by reverse-transcriptase polymerase chain reaction 
      assay, with acute limb ischemia, who developed heparin resistance. The patient 
      was managed by the departments of vascular surgery, anesthesia and intensive 
      care, and the Coagulation Service and Thrombosis Research from San Raffaele 
      Scientific Institute, Milan, Italy.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Baccellieri, Domenico
AU  - Baccellieri D
AD  - Department of Vascular Surgery, IRCCS San Raffaele Scientific Institute, 
      Vita-Salute San Raffaele University, Milan, Italy. Electronic address: 
      baccellieri.domenico@hsr.it.
FAU - Bilman, Victor
AU  - Bilman V
AD  - Department of Vascular Surgery, IRCCS San Raffaele Scientific Institute, 
      Vita-Salute San Raffaele University, Milan, Italy.
FAU - Apruzzi, Luca
AU  - Apruzzi L
AD  - Department of Vascular Surgery, IRCCS San Raffaele Scientific Institute, 
      Vita-Salute San Raffaele University, Milan, Italy.
FAU - Monaco, Fabrizio
AU  - Monaco F
AD  - Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific 
      Institute, Vita-Salute San Raffaele University, Milan, Italy.
FAU - D'Angelo, Armando
AU  - D'Angelo A
AD  - Coagulation Service and Thrombosis Research, IRCCS San Raffaele Scientific 
      Institute, Vita-Salute San Raffaele University, Milan, Italy.
FAU - Loschi, Diletta
AU  - Loschi D
AD  - Department of Vascular Surgery, IRCCS San Raffaele Scientific Institute, 
      Vita-Salute San Raffaele University, Milan, Italy.
FAU - Melissano, Germano
AU  - Melissano G
AD  - Department of Vascular Surgery, IRCCS San Raffaele Scientific Institute, 
      Vita-Salute San Raffaele University, Milan, Italy.
FAU - Chiesa, Roberto
AU  - Chiesa R
AD  - Department of Vascular Surgery, IRCCS San Raffaele Scientific Institute, 
      Vita-Salute San Raffaele University, Milan, Italy.
LA  - eng
PT  - Case Reports
DEP - 20200624
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Anticoagulants/pharmacology
MH  - *Betacoronavirus
MH  - Blood Coagulation/drug effects
MH  - COVID-19
MH  - Coronavirus Infections/*complications/diagnosis/epidemiology
MH  - *Drug Resistance
MH  - Heparin/*pharmacology
MH  - Humans
MH  - Ischemia/blood/*drug therapy/etiology
MH  - Lower Extremity/*blood supply
MH  - Male
MH  - Pandemics
MH  - Pneumonia, Viral/*complications/diagnosis/epidemiology
MH  - SARS-CoV-2
MH  - Tomography, X-Ray Computed
PMC - PMC7311350
EDAT- 2020/06/27 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/06/24
CRDT- 2020/06/27 06:00
PHST- 2020/06/01 00:00 [received]
PHST- 2020/06/16 00:00 [revised]
PHST- 2020/06/19 00:00 [accepted]
PHST- 2020/06/27 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/06/27 06:00 [entrez]
PHST- 2020/06/24 00:00 [pmc-release]
AID - S0890-5096(20)30547-1 [pii]
AID - 10.1016/j.avsg.2020.06.046 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2020 Oct;68:88-92. doi: 10.1016/j.avsg.2020.06.046. Epub 2020 Jun 
      24.