PMID- 32590129
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 138
DP  - 2020 Sep
TI  - Low free triiodothyronine levels are associated with risk of frailty in older 
      adults with type 2 diabetes mellitus.
PG  - 111013
LID - S0531-5565(20)30361-2 [pii]
LID - 10.1016/j.exger.2020.111013 [doi]
AB  - OBJECTIVES: With aging populations around the world, frailty is becoming more 
      prevalent increasing the need to early identify those at risk of frailty. The 
      association between thyroid hormone levels and frailty in subjects with type 2 
      diabetes mellitus (T2DM) remains unclear. The objective of the study was to 
      evaluate the relationship between thyroid hormone concentrations and frailty in 
      older adults with T2DM. METHODS: A total of 240 older adults with T2DM were 
      divided into three groups according to the frailty phenotype criteria: robust 
      group (n = 94), pre-frail (n = 110) and frail group (n = 36). Concentrations of 
      free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone 
      (TSH), 25-hydroxyvitamin D(3) [25(OH) D(3)], highly sensitive C-reactive protein 
      (hs-CRP) and interleukin-6 (IL-6) were determined. Handgrip strength was measured 
      using a Jamar hand dynamometer. Physical function was assessed by gait speed and 
      the timed go and up (TUG) test. Logistic regression analysis was performed to 
      evaluate the association between FT3 and frailty. RESULTS: The FT3 level was the 
      lowest among frail people (2.56 +/- 0.42 pg/mL), followed by pre-frail participants 
      (2.73 +/- 0.38 pg/mL), with the highest among the robust subjects 
      (2.83 +/- 0.43 pg/mL). FT3 level was positively correlated with handgrip strength 
      and gait speed (R = 0.313, P < 0.001; R = 0.250, P < 0.001, respectively), while 
      negatively correlated with TUG time (R = -0.276, P < 0.001). After adjusting for 
      age, sex, TSH, 25(OH) D(3) and estimate glomerular filtration rate (eGFR), 
      logistic regression showed that low FT3 was significantly associated with an 
      increased risk of frailty (odds ratio (OR): 4.53; 95% confidence interval (CI): 
      1.89-10.83; P = 0.001). CONCLUSION: Low levels of FT3 were associated with an 
      increased risk of frailty in older adults with T2DM. Measuring FT3 might be 
      useful for identifying those at high risk of frailty.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Xiu, Shuangling
AU  - Xiu S
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing 100053, China. Electronic address: 
      xiushuangling@126.com.
FAU - Mu, Zhijing
AU  - Mu Z
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing 100053, China.
FAU - Zhao, Lei
AU  - Zhao L
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing 100053, China.
FAU - Sun, Lina
AU  - Sun L
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing 100053, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200623
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Aged
MH  - *Diabetes Mellitus, Type 2
MH  - *Frailty/diagnosis
MH  - Hand Strength
MH  - Humans
MH  - Thyroid Function Tests
MH  - Thyrotropin
MH  - Thyroxine
MH  - Triiodothyronine
OTO - NOTNLM
OT  - China
OT  - Diabetes
OT  - FT3
OT  - Frailty
OT  - Thyroid disease
OT  - Thyroid function
COIS- Declaration of competing interest The authors declare no conflict of interests.
EDAT- 2020/06/27 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/06/27 06:00
PHST- 2020/02/07 00:00 [received]
PHST- 2020/05/27 00:00 [revised]
PHST- 2020/06/17 00:00 [accepted]
PHST- 2020/06/27 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/06/27 06:00 [entrez]
AID - S0531-5565(20)30361-2 [pii]
AID - 10.1016/j.exger.2020.111013 [doi]
PST - ppublish
SO  - Exp Gerontol. 2020 Sep;138:111013. doi: 10.1016/j.exger.2020.111013. Epub 2020 
      Jun 23.