PMID- 32590615
OWN - NLM
STAT- MEDLINE
DCOM- 20210407
LR  - 20210407
IS  - 1537-162X (Electronic)
IS  - 0362-5664 (Linking)
VI  - 43
IP  - 4
DP  - 2020 Jul/Aug
TI  - Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent 
      Patient.
PG  - 125-126
LID - 10.1097/WNF.0000000000000398 [doi]
AB  - BACKGROUND: Cataplexy is a clinical entity that is characterized by transient 
      muscle tone loss that mostly occurring as a part of narcolepsy. On the other 
      hand, isolated cataplexy (IC) (hereditary cataplexy) is defined as loss of muscle 
      tone that is not accompanied by narcolepsy. Emotional reactions may trigger IC 
      episodes. Additionally, human leukocyte antigen (HLA) DQB1 alleles were shown to 
      be related to IC. Various antidepressants are useful in the treatment of IC; 
      however, there is limited knowledge on the use of antipsychotics in the treatment 
      of IC. CASE REPORT: A 16-year-old adolescent girl was consulted child and 
      adolescent psychiatry outpatient clinic with complaint of sudden episodes of loss 
      of muscle tone. Her HLA typing showed HLA DQB1*03 haplotype. She was diagnosed 
      with IC and was prescribed aripiprazole 2.5 mg/d and her IC symptoms disappeared 
      and never recurred over 6 months of follow-up. CONCLUSIONS: In this case report, 
      we present an adolescent girl with IC that is successfully treated with 
      aripiprazole, an antipsychotic. This case report suggests that aripiprazole may 
      be safely used in some adolescents who diagnosed with IC.
FAU - Uzun, Necati
AU  - Uzun N
AD  - Department of Child and Adolescent Psychiatry, Necmettin Erbakan University Meram 
      School of Medicine.
FAU - Akinci, Mehmet Akif
AU  - Akinci MA
AD  - Department of Child and Adolescent Psychiatry, Ali Kemal Belviranli Maternity and 
      Children Hospital, Konya, Turkey.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Neuropharmacol
JT  - Clinical neuropharmacology
JID - 7607910
RN  - 0 (Antipsychotic Agents)
RN  - 82VFR53I78 (Aripiprazole)
SB  - IM
MH  - Adolescent
MH  - Antipsychotic Agents/*administration & dosage
MH  - Aripiprazole/*administration & dosage
MH  - Cataplexy/*diagnosis/*drug therapy
MH  - Female
MH  - Humans
MH  - Treatment Outcome
EDAT- 2020/06/27 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/06/27 06:00
PHST- 2020/06/27 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/06/27 06:00 [entrez]
AID - 10.1097/WNF.0000000000000398 [doi]
PST - ppublish
SO  - Clin Neuropharmacol. 2020 Jul/Aug;43(4):125-126. doi: 
      10.1097/WNF.0000000000000398.