PMID- 32593159
OWN - NLM
STAT- MEDLINE
DCOM- 20210517
LR  - 20210517
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 86
DP  - 2020 Sep
TI  - Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and 
      respiratory syndrome virus (PRRSV)-induced inflammatory response.
PG  - 106728
LID - S1567-5769(19)32500-7 [pii]
LID - 10.1016/j.intimp.2020.106728 [doi]
AB  - Porcine reproductive and respiratory syndrome virus (PRRSV) infection causes 
      severe systemic inflammation. Based on transcriptome sequencing data, a new 
      cold-inducible RNA-binding protein (CIRBP) was identified, and its upregulated 
      expression was detected in PRRSV-infected porcine alveolar macrophages (PAMs). 
      However, the immunoregulatoryeffect of CIRBP in PRRSV infection remains unclear. 
      In this study, we found that CIRBP, as an RNA-binging protein, migrates to the 
      cytoplasm from the nucleus and exists in cytoplasmic stress granules under PRRSV 
      infection. In addition, as a new pro-inflammatory factor, the overexpression of 
      CIRBP promotes the expression of inflammatory cytokines and oxidative stress as 
      showing the production of iNOS and ROS in PRRSV-infected cells, which contributes 
      to the inflammatory response via the NF-kappaB pathway. Our findings suggested that 
      CIRBP is involved in the regulation of PRRSV-induced inflammatory response.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Xiao, Xiao
AU  - Xiao X
AD  - School of Life Sciences, Tianjin University, Tianjin, China; Tianjin Key 
      Laboratory of Function and Application of Biological Macromolecular Structures, 
      Tianjin University, Tianjin, China.
FAU - Zhang, Wentao
AU  - Zhang W
AD  - School of Life Sciences, Tianjin University, Tianjin, China; Tianjin Key 
      Laboratory of Function and Application of Biological Macromolecular Structures, 
      Tianjin University, Tianjin, China.
FAU - Hua, Deping
AU  - Hua D
AD  - School of Life Sciences, Tianjin University, Tianjin, China; Tianjin Key 
      Laboratory of Function and Application of Biological Macromolecular Structures, 
      Tianjin University, Tianjin, China.
FAU - Zhang, Lilin
AU  - Zhang L
AD  - School of Life Sciences, Tianjin University, Tianjin, China; Tianjin Key 
      Laboratory of Function and Application of Biological Macromolecular Structures, 
      Tianjin University, Tianjin, China.
FAU - Meng, Wei
AU  - Meng W
AD  - School of Life Sciences, Tianjin University, Tianjin, China; Tianjin Key 
      Laboratory of Function and Application of Biological Macromolecular Structures, 
      Tianjin University, Tianjin, China.
FAU - Huang, Jinhai
AU  - Huang J
AD  - School of Life Sciences, Tianjin University, Tianjin, China; Tianjin Key 
      Laboratory of Function and Application of Biological Macromolecular Structures, 
      Tianjin University, Tianjin, China. Electronic address: jinhaih@tju.edu.cn.
FAU - Zhang, Lei
AU  - Zhang L
AD  - School of Life Sciences, Tianjin University, Tianjin, China; Tianjin Key 
      Laboratory of Function and Application of Biological Macromolecular Structures, 
      Tianjin University, Tianjin, China. Electronic address: zhanglei@tju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200624
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Cytokines)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Inflammation/complications/*metabolism
MH  - Macrophages, Alveolar/immunology/metabolism/ultrastructure/virology
MH  - NF-kappa B/metabolism
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Oxidative Stress
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/metabolism
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - RNA-Binding Proteins/genetics/*immunology/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction
MH  - Swine
MH  - Up-Regulation
OTO - NOTNLM
OT  - CIRBP
OT  - Inflammatory cytokines
OT  - NF-kappaB
OT  - Oxidative stress
OT  - PRRSV infection
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/06/28 06:00
MHDA- 2021/05/18 06:00
CRDT- 2020/06/28 06:00
PHST- 2019/11/06 00:00 [received]
PHST- 2020/06/15 00:00 [revised]
PHST- 2020/06/19 00:00 [accepted]
PHST- 2020/06/28 06:00 [pubmed]
PHST- 2021/05/18 06:00 [medline]
PHST- 2020/06/28 06:00 [entrez]
AID - S1567-5769(19)32500-7 [pii]
AID - 10.1016/j.intimp.2020.106728 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2020 Sep;86:106728. doi: 10.1016/j.intimp.2020.106728. Epub 
      2020 Jun 24.