PMID- 32593262
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20200831
IS  - 0004-1955 (Print)
IS  - 0004-1955 (Linking)
VI  - 82
IP  - 3
DP  - 2020
TI  - [Epidemiology and diagnosis of mutations in the ALK gene in patients with 
      non-small cell lung cancer in the Moscow region].
PG  - 18-23
LID - 10.17116/patol20208203118 [doi]
AB  - AIM OF STUDY: To determine a diagnostic algorithm for detecting translocation of 
      the ALK gene and its frequency in the Moscow region. MATERIALS AND METHODS: 
      During the priod between 2014 and 2018 (inclusive), 488 patients without 
      activating mutations in the EGFR gene in the Moscow region were tested. To detect 
      translocation of the ALK gene, fluorescence in situ hybridization (FISH) methods, 
      an immunohistochemical method, and, in some cases, a polymerase chain reaction 
      were used. RESULTS: Revealed ALK gene rearrangement in a population of patients 
      with lung adenocarcinoma amounted to an average of 7.6% of cases. With this, the 
      main method that we used was immunohistochemical method, applicable in more than 
      80% of cases. The use of other methods for verification of abnormalities in the 
      ALK gene was found necessary in rare cases (3.3%). CONCLUSIONS: Using the 
      algorithm presented in the article, it was possible to detect ALK gene 
      rearrangement in a population of patients with lung adenocarcinoma in the Moscow 
      region in an average of 7.6% of cases.
FAU - Byakhova, M M
AU  - Byakhova MM
AUID- ORCID: 0000-0002-5296-0068
AD  - Moscow Regional Clinical Research Institute named after M.F. Vladimirsky, Moscow, 
      Russia.
AD  - Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
FAU - Zavalishina, L E
AU  - Zavalishina LE
AUID- ORCID: 0000-0002-0677-7991
AD  - Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
FAU - AndreevA, Yu Yu
AU  - AndreevA YY
AUID- ORCID: 0000-0003-4749-6608
AD  - Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
FAU - Tyulyandin, S A
AU  - Tyulyandin SA
AUID- ORCID: 0000-0001-9807-2229
AD  - National Medical Research Center for Oncology named after N. N. Blokhin, Moscow, 
      Russia.
FAU - Tsimafeyeu, I V
AU  - Tsimafeyeu IV
AUID- ORCID: 0000-0002-7357-0392
AD  - Russian Society of Clinical Oncology, Moscow, Russia.
FAU - Imyanitov, E N
AU  - Imyanitov EN
AUID- ORCID: 0000-0003-4529-7891
AD  - National Medical Research Center for Oncology named after N.N. Petrov, St. 
      Petersburg, Russia.
FAU - Savelov, N A
AU  - Savelov NA
AD  - Moscow City Oncology Hospital No. 62, Moscow Region, Russia.
FAU - Demidova, I A
AU  - Demidova IA
AUID- ORCID: 0000-0003-4971-9852
AD  - Moscow City Oncology Hospital No. 62, Moscow Region, Russia.
FAU - Kekeyeva, T V
AU  - Kekeyeva TV
AUID- ORCID: 0000-0001-6759-2598
AD  - Medical Genetic Research Center named after Acad. N.P. Bochkov, Moscow, Russia.
FAU - Mueva, N M
AU  - Mueva NM
AUID- ORCID: 0000-0002-6598-5635
AD  - Aston Consulting JSC, Moscow, Russia.
FAU - Frank, G A
AU  - Frank GA
AUID- ORCID: 0000-0002-3719-5388
AD  - Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Epidemiologiya i diagnostika mutatsii v gene ALK u patsientov s nemelkokletochnym 
      rakom legkogo v Moskovskoi oblasti.
PL  - Russia (Federation)
TA  - Arkh Patol
JT  - Arkhiv patologii
JID - 0370604
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adenocarcinoma
MH  - Anaplastic Lymphoma Kinase/*genetics
MH  - *Carcinoma, Non-Small-Cell Lung/diagnosis/epidemiology/genetics
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Lung Neoplasms/diagnosis/epidemiology/genetics
MH  - Moscow
MH  - Mutation
MH  - Receptor Protein-Tyrosine Kinases
OTO - NOTNLM
OT  - ALK gene
OT  - ALK gene translocation
OT  - lung adenocarcinoma
OT  - lung cancer
EDAT- 2020/07/01 06:00
MHDA- 2020/09/01 06:00
CRDT- 2020/06/29 06:00
PHST- 2020/06/29 06:00 [entrez]
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
AID - 10.17116/patol20208203118 [doi]
PST - ppublish
SO  - Arkh Patol. 2020;82(3):18-23. doi: 10.17116/patol20208203118.