PMID- 32594338
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20210428
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 473
IP  - 1-2
DP  - 2020 Oct
TI  - Upregulation of long non-coding RNA MEG3 in type 2 diabetes mellitus complicated 
      with vascular disease: a case-control study.
PG  - 93-99
LID - 10.1007/s11010-020-03810-x [doi]
AB  - Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely 
      related to diabetes. In this study, we aimed to explore the possible role and 
      mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes 
      mellitus (T2DM) and its vascular complications. A case-control study involving 
      115 subjects was conducted, including 53 T2DM patients (37 patients with vascular 
      complication and 16 patients without vascular complications) and 62 healthy 
      subjects. We performed real-time polymerase chain reaction (RT-PCR) analysis of 
      the lncRNA MEG3 and miR-146a levels in peripheral blood mononuclear cells (PBMCs) 
      in the 115 samples. We found that the expression of lncRNA MEG3 was upregulated 
      in the T2DM patients with vascular complication (DC group) compared with T2DM 
      patients without vascular complication (D group) (P < 0.05) and the control group 
      (P < 0.01). miR-146a levels in DC group were significantly lower compared with 
      control group. There was a significant positive correlation between the 
      expression of lncRNA MEG3 and glucose (GLU) (r = 0.301, P = 0.0011) and 
      hemoglobin A1C (HbA1c) (r = 0.477, P = 0.0006). Our study suggests MEG3 may play 
      as an important role in progression of diabetes-related vascular complications, 
      contributing to a novel understanding of pathogenesis and prognosis for diabetes 
      and its complications.
FAU - Chang, Wei-Wei
AU  - Chang WW
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Wannan 
      Medical College, Wenchang West Road 22, Wuhu, 241002, Anhui, China.
FAU - Zhang, Liu
AU  - Zhang L
AD  - Department of Hospital Infection Management Office, Wuhu Hospital of Traditional 
      Chinese Medicine, Wuhu, 241000, Anhui, China.
FAU - Yao, Xin-Ming
AU  - Yao XM
AD  - Department of Endocrine, The First Affiliated Hospital of Wannan Medical College, 
      Wuhu, 241002, Anhui, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Wannan 
      Medical College, Wenchang West Road 22, Wuhu, 241002, Anhui, China.
FAU - Zhu, Li-Jun
AU  - Zhu LJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Wannan 
      Medical College, Wenchang West Road 22, Wuhu, 241002, Anhui, China.
FAU - Fang, Zheng-Mei
AU  - Fang ZM
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Wannan 
      Medical College, Wenchang West Road 22, Wuhu, 241002, Anhui, China.
FAU - Zhao, Ying
AU  - Zhao Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Wannan 
      Medical College, Wenchang West Road 22, Wuhu, 241002, Anhui, China.
FAU - Yao, Ying-Shui
AU  - Yao YS
AUID- ORCID: 0000-0001-6864-5145
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Wannan 
      Medical College, Wenchang West Road 22, Wuhu, 241002, Anhui, China. 
      yingshuiyao@126.com.
FAU - Jin, Yue-Long
AU  - Jin YL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Wannan 
      Medical College, Wenchang West Road 22, Wuhu, 241002, Anhui, China. 
      94017416@qq.com.
LA  - eng
GR  - 81441127/the National Natural Science Foundation of China (CN)/
PT  - Journal Article
DEP - 20200627
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Blood Glucose)
RN  - 0 (MEG3 non-coding RNA, human)
RN  - 0 (MIRN146 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Angiopathies/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - MicroRNAs/blood
MH  - Middle Aged
MH  - RNA, Long Noncoding/*biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Up-Regulation
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Long non-coding RNA
OT  - MEG3
OT  - Vascular complications
EDAT- 2020/07/01 06:00
MHDA- 2021/04/29 06:00
CRDT- 2020/06/29 06:00
PHST- 2020/03/18 00:00 [received]
PHST- 2020/06/18 00:00 [accepted]
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2020/06/29 06:00 [entrez]
AID - 10.1007/s11010-020-03810-x [pii]
AID - 10.1007/s11010-020-03810-x [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2020 Oct;473(1-2):93-99. doi: 10.1007/s11010-020-03810-x. Epub 
      2020 Jun 27.