PMID- 32594414
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20210922
IS  - 2520-8721 (Electronic)
IS  - 1109-3099 (Linking)
VI  - 19
IP  - 4
DP  - 2020 Dec
TI  - Correlation of serum C1q-tumour necrosis factor-related protein 5 levels with 
      metabolic parameters and carotid intima-media thickness in newly diagnosed type 2 
      diabetes mellitus patients.
PG  - 559-564
LID - 10.1007/s42000-020-00223-9 [doi]
AB  - PURPOSE: Recent studies have shown that cytokines secreted from adipose tissues 
      play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). CTRP5 
      (C1q-TNF-related protein 5) is a novel adipokine that has been shown to be 
      associated with glucose and lipid metabolism. Varying levels of CTRP5 have been 
      reported in individuals with diabetes, obesity and coronary artery disease. The 
      aim of this study was to examine serum levels of CTRP5 and to show the 
      relationship with cardiometabolic parameters in T2DM patients. METHOD: The study 
      included 40 T2DM patients and 40 age- and sex-matched healthy control subjects. 
      All the study participants were evaluated with respect to BMI, waist 
      circumference, lipid profile, insulin resistance (HOMA-IR), serum CTRP5 levels, 
      carotid intima-media thickness, and hs-CRP. RESULTS: No statistically significant 
      differences were found between the control group and the diabetic group in terms 
      of age, sex, or BMI. Serum CTRP5 levels (T2DM = 94.55 +/- 28.70 ng/ml, 
      control = 76.02 +/- 27.22 ng/ml, P = 0.004*) were significantly higher in the group 
      of newly diagnosed diabetic patients. A positive correlation was found between 
      CTRP5 and the cardiometabolic parameters of carotid intima-media thickness 
      (CIMT), hs-CRP, HOMA-IR and BMI. Regression analysis results showed that CTRP5 
      levels were independently correlated with insulin resistance estimated by 
      HOMA-IR. CONCLUSION: Serum CTRP5 levels were correlated with cardiometabolic 
      parameters and could therefore be a promising indicator of metabolic status and a 
      possible biomarker of insulin resistance. However, the contradictory results 
      reported in different studies indicate the need for further research to assess 
      the significance of CTRP5 for diagnosis and monitoring of treatment efficacy.
FAU - Ucar, I Merve B
AU  - Ucar IMB
AUID- ORCID: 0000-0002-5051-0450
AD  - Department of Rheumatology, Aydin Adnan Menderes University, Efeler, 09100, 
      Aydin, Turkey. ucarmerve1988@hotmail.com.
FAU - Calan, Mehmet
AU  - Calan M
AUID- ORCID: 0000-0002-5614-0710
AD  - Private Practice, Izmir, Turkey.
FAU - Tatar, Erhan
AU  - Tatar E
AUID- ORCID: 0000-0002-5068-4231
AD  - Health Sciences University, Bozyaka Research and Training Hospital, Izmir, 
      Turkey.
FAU - Chousein, Roukie
AU  - Chousein R
AD  - Memorial Sisli Hospital, Izmir, Turkey.
FAU - Fenercioglu, Ozge E
AU  - Fenercioglu OE
AD  - Buca Women Health and Children's Hospital, Izmir, Turkey.
FAU - Bozkaya, Giray
AU  - Bozkaya G
AUID- ORCID: 0000-0002-5756-5796
AD  - Health Sciences University, Bozyaka Research and Training Hospital, Izmir, 
      Turkey.
FAU - Yuksel, Arif
AU  - Yuksel A
AUID- ORCID: 0000-0002-8568-5787
AD  - Health Sciences University, Bozyaka Research and Training Hospital, Izmir, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200627
PL  - Switzerland
TA  - Hormones (Athens)
JT  - Hormones (Athens, Greece)
JID - 101142469
RN  - 0 (Biomarkers)
RN  - 0 (C1QTNF5 protein, human)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - *Body Mass Index
MH  - Cardiovascular Diseases/*diagnostic imaging
MH  - *Carotid Intima-Media Thickness
MH  - Collagen/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - BMI
OT  - CTRP5
OT  - Carotid intima-media thickness
OT  - HOMA-IR
OT  - Hs-CRP
OT  - Type 2 diabetes mellitus
EDAT- 2020/07/01 06:00
MHDA- 2021/09/23 06:00
CRDT- 2020/06/29 06:00
PHST- 2020/03/11 00:00 [received]
PHST- 2020/06/15 00:00 [accepted]
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2020/06/29 06:00 [entrez]
AID - 10.1007/s42000-020-00223-9 [pii]
AID - 10.1007/s42000-020-00223-9 [doi]
PST - ppublish
SO  - Hormones (Athens). 2020 Dec;19(4):559-564. doi: 10.1007/s42000-020-00223-9. Epub 
      2020 Jun 27.