PMID- 32597286
OWN - NLM
STAT- MEDLINE
DCOM- 20211215
LR  - 20211215
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 50
IP  - 6
DP  - 2021 Aug
TI  - Dendritic Cells Currently under the Spotlight; Classification and Subset Based 
      upon New Markers.
PG  - 646-661
LID - 10.1080/08820139.2020.1783289 [doi]
AB  - Dendritic cells (DCs) are considered as a subset of mononuclear phagocytes that 
      composed of multiple subsets with distinct phenotypic features. DCs play crucial 
      roles in the initiation and modulation of immune responses to both allo- and 
      auto-antigens during pathogenic settings, encompassing infectious diseases, 
      cancer, autoimmunity, transplantation, as well as vaccination. DCs play a role in 
      preventing autoimmunity via inducing tolerance to self-antigens. This review 
      focus on the most common subsets of DCs in human. Owing to the low frequencies of 
      DC cells in blood and tissues and also the lack of specific DC markers, studies 
      of DCs have been greatly hindered. Human DCs arise by a dedicated pathway of 
      lympho-myeloid hematopoiesis and give rise into specialized subtypes under the 
      influence of transcription factors that are specific for each linage. In humans, 
      the classification of DCs has been generally separated into the blood and 
      cutaneous subsets, mainly because these parts are more comfortable to examine in 
      humans.
FAU - Soltani, Samaneh
AU  - Soltani S
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
AUID- ORCID: 0000-0002-8164-8831
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
AD  - Inflammation Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Farhadi, Elham
AU  - Farhadi E
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
AD  - Inflammation Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200629
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (Biomarkers)
SB  - IM
MH  - Autoimmunity
MH  - Biomarkers/analysis/metabolism
MH  - Dendritic Cells/*classification/immunology/metabolism
MH  - Humans
MH  - Immune Tolerance
OTO - NOTNLM
OT  - Human dendritic cell subset
OT  - dendritic cell classification
OT  - immune responses
OT  - tolerogenic dendritic cell
EDAT- 2020/07/01 06:00
MHDA- 2021/12/16 06:00
CRDT- 2020/06/30 06:00
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2021/12/16 06:00 [medline]
PHST- 2020/06/30 06:00 [entrez]
AID - 10.1080/08820139.2020.1783289 [doi]
PST - ppublish
SO  - Immunol Invest. 2021 Aug;50(6):646-661. doi: 10.1080/08820139.2020.1783289. Epub 
      2020 Jun 29.