PMID- 32598492
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1745-4514 (Electronic)
IS  - 0145-8884 (Linking)
VI  - 44
IP  - 9
DP  - 2020 Sep
TI  - Luteolin improves hypercholesterolemia and glucose intolerance through 
      LXRalpha-dependent pathway in diet-induced obese mice.
PG  - e13358
LID - 10.1111/jfbc.13358 [doi]
AB  - Luteolin, a naturally derived flavonoid, exerts beneficial effects such as 
      antitumor, antioxidant, and anti-inflammatory effects. However, the molecular 
      mechanism underlying the effect of luteolin in hypercholesterolemia remains 
      unclear. In this study, we demonstrated that luteolin upregulated the expression 
      of liver X receptor (LXR) alpha, ATP-binding cassette transporter G1 (ABCG1), and 
      scavenger receptor class B member 1 (SRB1), which play a major role in 
      cholesterol efflux, in HepG2 hepatocytes. Luteolin-stimulated expression of ABCG1 
      and SRB1 was reversed by inhibitory compound of LXRalpha. Luteolin administration 
      also upregulated the expression of ABCG1, and SRB1 as well as cholesterol 7 
      alpha-hydroxylase (Cyp7alpha1) in the liver of diet-induced obese mice. Luteolin 
      decreased the level of blood cholesterol and non-high-density lipoprotein 
      cholesterol in obese mice. In addition, luteolin ameliorated glucose intolerance 
      and reduced expression of gluconeogenesis-associated enzymes in an LXRalpha-dependent 
      manner. PRACTICAL APPLICATIONS: Luteolin is known to possess various 
      pharmacological activities. This research revealed that luteolin ameliorates 
      hypercholesterolemia and glucose intolerance in diet-induced obesity. The results 
      indicate that the potential properties of luteolin in cholesterol metabolism 
      could be explained, at least in part, as being due to upregulated expression of 
      ABCG1, and SRB1 through activation of liver X receptor, LXRalpha signaling pathway in 
      HepG2 cells.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Park, Hee-Sook
AU  - Park HS
AUID- ORCID: 0000-0003-1644-1970
AD  - Research group of Healthcare, Korea Food Research Institute, Wanju-gun, Republic 
      of Korea.
FAU - Lee, Kyunhee
AU  - Lee K
AUID- ORCID: 0000-0002-5147-9643
AD  - Research group of Healthcare, Korea Food Research Institute, Wanju-gun, Republic 
      of Korea.
AD  - Department of Food Biotechnology, Korea University of Science & Technology, 
      Wanju-gun, Republic of Korea.
FAU - Kim, Soon-Hee
AU  - Kim SH
AD  - Research group of Healthcare, Korea Food Research Institute, Wanju-gun, Republic 
      of Korea.
FAU - Hong, Moon Ju
AU  - Hong MJ
AD  - Research group of Healthcare, Korea Food Research Institute, Wanju-gun, Republic 
      of Korea.
AD  - Department of Food Biotechnology, Korea University of Science & Technology, 
      Wanju-gun, Republic of Korea.
FAU - Jeong, Nam-Joo
AU  - Jeong NJ
AD  - Research group of Healthcare, Korea Food Research Institute, Wanju-gun, Republic 
      of Korea.
FAU - Kim, Myung-Sunny
AU  - Kim MS
AUID- ORCID: 0000-0002-5020-3397
AD  - Research group of Healthcare, Korea Food Research Institute, Wanju-gun, Republic 
      of Korea.
AD  - Department of Food Biotechnology, Korea University of Science & Technology, 
      Wanju-gun, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200629
PL  - United States
TA  - J Food Biochem
JT  - Journal of food biochemistry
JID - 7706045
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (Orphan Nuclear Receptors)
RN  - KUX1ZNC9J2 (Luteolin)
SB  - IM
MH  - ATP Binding Cassette Transporter 1
MH  - Animals
MH  - Diet
MH  - *Glucose Intolerance/drug therapy
MH  - *Hypercholesterolemia/drug therapy/etiology
MH  - Luteolin/pharmacology/therapeutic use
MH  - Mice
MH  - Mice, Obese
MH  - Orphan Nuclear Receptors/metabolism
OTO - NOTNLM
OT  - LXRalpha
OT  - cholesterol metabolism
OT  - diet-induced obesity
OT  - gluconeogenesis
OT  - luteolin
EDAT- 2020/07/01 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/06/30 06:00
PHST- 2020/04/03 00:00 [received]
PHST- 2020/06/08 00:00 [revised]
PHST- 2020/06/08 00:00 [accepted]
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/06/30 06:00 [entrez]
AID - 10.1111/jfbc.13358 [doi]
PST - ppublish
SO  - J Food Biochem. 2020 Sep;44(9):e13358. doi: 10.1111/jfbc.13358. Epub 2020 Jun 29.