PMID- 32599929
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 12
IP  - 6
DP  - 2020 Jun 24
TI  - Role of Colposcopy after Treatment for Cervical Intraepithelial Neoplasia.
LID - 10.3390/cancers12061683 [doi]
LID - 1683
AB  - Colposcopy is often used in follow-up after treatment for cervical 
      intraepithelial neoplasia (CIN) despite its marked inter-observer variability and 
      low sensitivity. Our objective was to assess the role of colposcopy in 
      post-treatment follow-up in comparison to hrHPV (high-risk human papillomavirus) 
      testing, cytology, and cone margin status. Altogether, 419 women treated for 
      histological high-grade lesion (HSIL) with large loop excision of the 
      transformation zone (LLETZ) attended colposcopy with cytology and hrHPV test at 
      six months. Follow-up for recurrence of HSIL continued for 24 months. Colposcopy 
      was considered positive if colposcopic impression was recorded as high grade and 
      cytology if HSIL, ASC-H (atypical squamous cells, cannot exclude HSIL), or AGC-FN 
      (atypical glandular cells, favor neoplasia) were present. Overall, 10 (10/419, 
      2.4%) recurrent HSIL cases were detected, 5 at 6 months and 5 at 12 months. 
      Colposcopic impression was recorded at 407/419 6-month visits and was positive 
      for 11/407 (2.7%). None of them had recurrent lesions, resulting in 0% 
      sensitivity and 97% specificity for colposcopy. Sensitivity for the hrHPV test at 
      6 months was 100% and specificity 85%, for cytology 40% and 99%, and for margin 
      status at treatment 60% and 82%, respectively. While the hrHPV test is highly 
      sensitive in predicting recurrence after local treatment for CIN, colposcopy in 
      an unselected population is not useful in follow-up after treatment of CIN.
FAU - Heinonen, Annu
AU  - Heinonen A
AD  - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki 
      University Hospital, 00029 Helsinki, Finland.
FAU - Jakobsson, Maija
AU  - Jakobsson M
AD  - Department of Obstetrics and Gynecology, Hyvinkaa Hospital, HUCH and University 
      of Helsinki, 05850 Hyvinkaa, Finland.
FAU - Kiviharju, Mari
AU  - Kiviharju M
AD  - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki 
      University Hospital, 00029 Helsinki, Finland.
FAU - Virtanen, Seppo
AU  - Virtanen S
AD  - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki 
      University Hospital, 00029 Helsinki, Finland.
FAU - Aro, Karoliina
AU  - Aro K
AD  - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki 
      University Hospital, 00029 Helsinki, Finland.
FAU - Kyrgiou, Maria
AU  - Kyrgiou M
AD  - Department of Gut, Metabolism and Reproduction & Department of Surgery and 
      Cancer, Institute of Reproductive and Developmental Biology, Faculty of Medicine, 
      Imperial College London, London SW7 2AZ, UK.
AD  - West London Gynaecological Cancer Centre, Imperial College Healthcare NHS Trust, 
      London W2 1NY, UK.
FAU - Nieminen, Pekka
AU  - Nieminen P
AD  - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki 
      University Hospital, 00029 Helsinki, Finland.
FAU - Kalliala, Ilkka
AU  - Kalliala I
AUID- ORCID: 0000-0002-7664-0587
AD  - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki 
      University Hospital, 00029 Helsinki, Finland.
AD  - Department of Gut, Metabolism and Reproduction & Department of Surgery and 
      Cancer, Institute of Reproductive and Developmental Biology, Faculty of Medicine, 
      Imperial College London, London SW7 2AZ, UK.
LA  - eng
GR  - TYH2019241/Helsingin ja Uudenmaan Sairaanhoitopiiri/
GR  - TYH 2020401/Helsingin ja Uudenmaan Sairaanhoitopiiri/
GR  - ./Emil Aaltosen Saatio/
GR  - ./Paulon Saatio/
GR  - ./Suomen Laaketieteen Saatio/
GR  - ./Jalmari ja Rauha Ahokkaan Saatio/
GR  - ./Academy of Finland/
PT  - Journal Article
DEP - 20200624
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC7352967
OTO - NOTNLM
OT  - CIN
OT  - colposcopy
OT  - follow-up
OT  - test of cure
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/01 06:00
MHDA- 2020/07/01 06:01
PMCR- 2020/06/24
CRDT- 2020/07/01 06:00
PHST- 2020/05/16 00:00 [received]
PHST- 2020/06/13 00:00 [revised]
PHST- 2020/06/18 00:00 [accepted]
PHST- 2020/07/01 06:00 [entrez]
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2020/07/01 06:01 [medline]
PHST- 2020/06/24 00:00 [pmc-release]
AID - cancers12061683 [pii]
AID - cancers-12-01683 [pii]
AID - 10.3390/cancers12061683 [doi]
PST - epublish
SO  - Cancers (Basel). 2020 Jun 24;12(6):1683. doi: 10.3390/cancers12061683.