PMID- 32601691
OWN - NLM
STAT- MEDLINE
DCOM- 20211208
LR  - 20211214
IS  - 1528-8951 (Electronic)
IS  - 0148-0731 (Print)
IS  - 0148-0731 (Linking)
VI  - 142
IP  - 12
DP  - 2020 Dec 1
TI  - The Influence of Anterior Cruciate Ligament Matrix Mechanical Properties on 
      Simulated Whole-Knee Biomechanics.
LID - 10.1115/1.4047658 [doi]
LID - 121012
AB  - Knee finite element (FE) models are used to study tissue deformation in response 
      to complex loads. Typically, ligaments are modeled using transversely isotropic, 
      hyperelastic material models fitted to tension data along the predominant fiber 
      direction (longitudinal) and, less commonly, to tension data orthogonal to the 
      fiber direction (transverse). Currently, the shear and bulk responses of the 
      anterior cruciate ligament (ACL) are not fitted to experimental data. In this 
      study, a newly proposed material model was fitted to longitudinal tension, 
      transverse tension, and shear experimental data. The matrix transverse tensile, 
      shear, and bulk stiffnesses were then varied independently to determine the 
      impact of each property on knee kinematics and tissue deformation in a whole-knee 
      FE model. The range of values for each parameter was chosen based on published FE 
      studies of the knee. For a knee at full extension under 134 N anterior tibial 
      force (ATF), increasing matrix transverse tensile stiffness, shear stiffness, or 
      bulk stiffness decreased anterior tibial translation (ATT), ACL longitudinal 
      strain, and ACL shear strain. For a knee under 134 N ATF and 1600 N compression, 
      changing the ACL matrix mechanical properties caused variations in ATT and thus 
      changed cartilage deformation contours by changing the point of contact between 
      the femoral and the tibial cartilage. These findings indicate that material 
      models for the ACL must describe matrix material properties to best predict the 
      in vivo response to applied loads.
CI  - Copyright (c) 2020 by ASME.
FAU - Rosario, Ryan
AU  - Rosario R
AD  - Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 
      48109.
FAU - Marchi, Benjamin C
AU  - Marchi BC
AD  - Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 
      48109.
FAU - Arruda, Ellen M
AU  - Arruda EM
AD  - Department of Mechanical Engineering, Program in Macromolecular Science and 
      Engineering, University of Michigan, Ann Arbor, MI 48109; Department of 
      Biomedical Engineering, Program in Macromolecular Science and Engineering, 
      University of Michigan, Ann Arbor, MI 48109.
FAU - Coleman, Rhima M
AU  - Coleman RM
AD  - Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 
      48109; Department of Biomedical Engineering, University of Michigan, Ann Arbor, 
      MI 48109.
LA  - eng
GR  - R21 AR074011/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Biomech Eng
JT  - Journal of biomechanical engineering
JID - 7909584
SB  - IM
MH  - *Anterior Cruciate Ligament
MH  - Biomechanical Phenomena
MH  - *Knee Joint
MH  - Tibia
PMC - PMC7580848
EDAT- 2020/07/01 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/12/01
CRDT- 2020/07/01 06:00
PHST- 2019/10/24 00:00 [received]
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/07/01 06:00 [entrez]
PHST- 2021/12/01 00:00 [pmc-release]
AID - 1084898 [pii]
AID - BIO-19-1476 [pii]
AID - 10.1115/1.4047658 [doi]
PST - ppublish
SO  - J Biomech Eng. 2020 Dec 1;142(12):121012. doi: 10.1115/1.4047658.