PMID- 32602764
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20220428
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 131
IP  - 12
DP  - 2021 Dec
TI  - BAFF serum and CSF levels in patients with multiple sclerosis and infectious 
      nervous system diseases.
PG  - 1231-1236
LID - 10.1080/00207454.2020.1784167 [doi]
AB  - PURPOSE: Multiple sclerosis (MS) is the most common immune-mediated CNS disease, 
      characterised by demyelination and progressive neurological disability. The 
      B-cell activating factor BAFF has been described as one important factor in the 
      pathophysiology of different autoimmune diseases. METHODS: We measured BAFF 
      levels in the serum and cerebrospinal fluid (CSF) in 50 consecutive patients with 
      MS and 35 patients with infectious CNS disease (ID). 52 patients with other, 
      non-inflammatory disorders (OND), served as controls. RESULTS: BAFF-serum levels 
      in ID patients were higher than in patients diagnosed with MS (ID 
      0.55 +/- 0.24 ng/ml, MS 0.43 +/- 0.14 ng/ml, OND 0.45 +/- 0.24 ng/ml; p = 0.09). 
      Interestingly, MS patients had lower BAFF CSF levels compared to the controls and 
      ID patients, and the CSF levels in the latter were elevated compared to those of 
      the controls (MS 0.17 +/- 0.11 ng/ml, OND 0.25 +/- 0.14 ng/ml, ID 0.97 +/- 0.78 ng/ml; 
      p < 0.001). CONCLUSIONS: The ID patients' having higher absolute BAFF levels in 
      the CSF than in the serum indicates that the increased BAFF CSF levels were 
      caused by intrathecal synthesis rather than passive transfer via a disturbed 
      blood-brain-barrier. The significantly decreased BAFF CSF levels in MS patients 
      were a surprising result of our study. Although it has been reported that 
      astrocytes in active MS lesions can express BAFF, the soluble form was not 
      increased in the CSF of MS patients. It remains unclear whether the inflammatory 
      features of active MS plaques are truly represented by the CSF compartment.
FAU - Braun, Tobias
AU  - Braun T
AUID- ORCID: 0000-0003-1738-2773
AD  - Department of Neurology, Faculty of Medicine, Justus-Liebig-University, Giessen, 
      Germany.
AD  - Heart & Brain Research Group, Justus-Liebig-University Giessen and Kerckhoff 
      Clinic, Bad Nauheim, Germany.
FAU - Juenemann, Martin
AU  - Juenemann M
AD  - Department of Neurology, Faculty of Medicine, Justus-Liebig-University, Giessen, 
      Germany.
AD  - Heart & Brain Research Group, Justus-Liebig-University Giessen and Kerckhoff 
      Clinic, Bad Nauheim, Germany.
FAU - Dornes, Kathrin
AU  - Dornes K
AD  - Department of Neurology, Faculty of Medicine, Justus-Liebig-University, Giessen, 
      Germany.
FAU - El-Shazly, Jasmin
AU  - El-Shazly J
AD  - Heart & Brain Research Group, Justus-Liebig-University Giessen and Kerckhoff 
      Clinic, Bad Nauheim, Germany.
FAU - Schramm, Patrick
AU  - Schramm P
AUID- ORCID: 0000-0001-5158-6708
AD  - Heart & Brain Research Group, Justus-Liebig-University Giessen and Kerckhoff 
      Clinic, Bad Nauheim, Germany.
AD  - Department of Anaesthesiology, University Medical Centre Mainz, Mainz, Germany.
FAU - Bick-Ackerschott, Sandra
AU  - Bick-Ackerschott S
AD  - Department of Neurology, Faculty of Medicine, Justus-Liebig-University, Giessen, 
      Germany.
FAU - Kaps, Manfred
AU  - Kaps M
AD  - Department of Neurology, Faculty of Medicine, Justus-Liebig-University, Giessen, 
      Germany.
FAU - Gerriets, Tibo
AU  - Gerriets T
AD  - Department of Neurology, Faculty of Medicine, Justus-Liebig-University, Giessen, 
      Germany.
AD  - Heart & Brain Research Group, Justus-Liebig-University Giessen and Kerckhoff 
      Clinic, Bad Nauheim, Germany.
AD  - Department of Neurology, Gesundheitszentrum Wetterau, Bad Nauheim, Germany.
FAU - Blaes, Franz
AU  - Blaes F
AD  - Department of Neurology, Faculty of Medicine, Justus-Liebig-University, Giessen, 
      Germany.
AD  - Department of Neurology, Klinikum Oberberg, Gummersbach, Germany.
FAU - Tschernatsch, Marlene
AU  - Tschernatsch M
AUID- ORCID: 0000-0003-2725-0811
AD  - Department of Neurology, Faculty of Medicine, Justus-Liebig-University, Giessen, 
      Germany.
AD  - Heart & Brain Research Group, Justus-Liebig-University Giessen and Kerckhoff 
      Clinic, Bad Nauheim, Germany.
AD  - Department of Neurology, Gesundheitszentrum Wetterau, Bad Nauheim, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200630
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (TNFSF13B protein, human)
SB  - IM
MH  - Adult
MH  - B-Cell Activating Factor/*blood/*cerebrospinal fluid
MH  - Central Nervous System Infections/*blood/*cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*blood/*cerebrospinal fluid
OTO - NOTNLM
OT  - B-cell activating factor
OT  - autoimmunity
OT  - cerebrospinal fluid
OT  - multiple sclerosis
EDAT- 2020/07/01 06:00
MHDA- 2022/02/09 06:00
CRDT- 2020/07/01 06:00
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2020/07/01 06:00 [entrez]
AID - 10.1080/00207454.2020.1784167 [doi]
PST - ppublish
SO  - Int J Neurosci. 2021 Dec;131(12):1231-1236. doi: 10.1080/00207454.2020.1784167. 
      Epub 2020 Jun 30.