PMID- 32603484
OWN - NLM
STAT- MEDLINE
DCOM- 20210309
LR  - 20221005
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 93
IP  - 1
DP  - 2021 Jan
TI  - Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19.
PG  - 528-532
LID - 10.1002/jmv.26235 [doi]
AB  - The situation of the coronavirus disease 2019 (COVID-19) continues to evolve, our 
      study explored the significance of serum levels of matrix metalloproteinase 3 
      (MMP3) as a marker for patients with COVID-19. Sixty-two COVID-19 patients in the 
      First Hospital of Hunan University of Chinese Medicine and Loudi Center for 
      Diseases Prevention and Control, from January to March 2020, were sampled as the 
      novel coronavirus pneumonia infected group. One hundred and thirty-one cases from 
      the First Hospital of Hunan University of Chinese Medicine, including 67 healthy 
      individuals and 64 non-COVID-19 inpatients, served as the noninfected group. 
      Approximately every 5 days, sera from 20 cases were collected and analyzed three 
      times, using an automatic biochemical analyzer, to detect serum MMP3 
      concentrations. Correlation was analyzed between MMP3 and other proinflammatory 
      cytokines. Following normality tests, differences in serum MMP3 levels between 
      the infected and noninfected group were analyzed via SPSS (version 25.0) 
      software, using the Wilcoxon rank sum test. The MMP3 concentration was 44.44 
      (23.46 ~ 72.12) ng/mL in the infected group and 32.42 (28.16 ~ 41.21) ng/mL in 
      the noninfected group. The difference between the two groups was statistically 
      significant (Z = -2.799, P = .005 < .05). A positive correlation was found 
      between MMP3 and interleukin 1beta (IL-1beta; r = .681, P = .000 < .05), and IL-6 
      (r = .529, P = .002 < .05). Serum MMP3 concentration, measured over three 
      separate time points, were 55.98 (30.80 ~ 75.97) ng/mL, 34.84 
      (0.00 ~ 51.84) ng/mL, and 5.71 (0.00 ~ 40.46) ng/mL, respectively. Detection of 
      serum MMP3 levels may play an important role in the development of therapeutic 
      approaches for COVID-19 and may indicate the severity of disease.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Shi, Shengjie
AU  - Shi S
AD  - Hunan University of Chinese Medicine, Changsha, Hunan, China.
FAU - Su, Min
AU  - Su M
AD  - Department of Medical Laboratory and Pathology Center, The First Hospital of 
      Hunan University of Chinese Medicine, Changsha, Hunan, China.
FAU - Shen, Ge
AU  - Shen G
AD  - Loudi Center for Diseases Prevention and Control, Loudi, Hunan, China.
FAU - Hu, Yan
AU  - Hu Y
AD  - Department of Medical Laboratory and Pathology Center, The First Hospital of 
      Hunan University of Chinese Medicine, Changsha, Hunan, China.
FAU - Yi, Fan
AU  - Yi F
AD  - Hunan University of Chinese Medicine, Changsha, Hunan, China.
FAU - Zeng, Ziyan
AU  - Zeng Z
AD  - Loudi Center for Diseases Prevention and Control, Loudi, Hunan, China.
FAU - Zhu, Pan
AU  - Zhu P
AD  - Loudi Center for Diseases Prevention and Control, Loudi, Hunan, China.
FAU - Yang, Gang
AU  - Yang G
AD  - Loudi Center for Diseases Prevention and Control, Loudi, Hunan, China.
FAU - Zhou, Hui
AU  - Zhou H
AD  - Department of Medical Laboratory and Pathology Center, The First Hospital of 
      Hunan University of Chinese Medicine, Changsha, Hunan, China.
FAU - Li, Qiong
AU  - Li Q
AD  - Department of Medical Laboratory and Pathology Center, The First Hospital of 
      Hunan University of Chinese Medicine, Changsha, Hunan, China.
FAU - Xie, Xiaobing
AU  - Xie X
AUID- ORCID: 0000-0003-4413-3983
AD  - Department of Medical Laboratory and Pathology Center, The First Hospital of 
      Hunan University of Chinese Medicine, Changsha, Hunan, China.
LA  - eng
GR  - 2020SK3018/Novel Coronavirus Pneumonia Emergency Project of Hunan Provincial 
      Science and Technology Department/
GR  - 2018YXJS02/First-class Discipline Open Fund Project of Hunan University of 
      Chinese Medicine/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200711
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Biomarkers/blood
MH  - COVID-19/*blood/*enzymology
MH  - Gene Expression Regulation, Enzymologic
MH  - Humans
MH  - Inflammation/metabolism
MH  - Matrix Metalloproteinase 3/*blood/metabolism
PMC - PMC7362036
OTO - NOTNLM
OT  - COVID-19
OT  - MMP3 concentrations
OT  - inflammation
COIS- The authors declare that there are no conflict of interests.
EDAT- 2020/07/01 06:00
MHDA- 2021/03/10 06:00
PMCR- 2020/07/11
CRDT- 2020/07/01 06:00
PHST- 2020/06/01 00:00 [received]
PHST- 2020/06/19 00:00 [accepted]
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2021/03/10 06:00 [medline]
PHST- 2020/07/01 06:00 [entrez]
PHST- 2020/07/11 00:00 [pmc-release]
AID - JMV26235 [pii]
AID - 10.1002/jmv.26235 [doi]
PST - ppublish
SO  - J Med Virol. 2021 Jan;93(1):528-532. doi: 10.1002/jmv.26235. Epub 2020 Jul 11.