PMID- 32603611
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20210719
IS  - 1939-6376 (Electronic)
IS  - 1939-6368 (Linking)
VI  - 66
IP  - 4
DP  - 2020 Aug
TI  - Monocyte chemotactic protein-1 plays a role in ovarian dysfunction related to 
      high-fat diet-induced obesity.
PG  - 236-243
LID - 10.1080/19396368.2020.1780649 [doi]
AB  - Obesity, known to cause a systemic elevation in monocyte chemotactic protein-1 
      (MCP-1), adversely affects normal ovarian function. The aim of this study was to 
      determine whether MCP-1 plays a role in ovarian dysfunction that is related to 
      obesity induced by high-fat (HF) diet intake. Wild type (WT) C57BL/6J mice were 
      fed either normal chow (NC) (Group 1, control group) or HF diet (Group 2). To 
      assess whether MCP-1 is involved in HF-diet-induced ovarian dysfunction, MCP-1 
      knock-out mice were fed HF diet (Group 3). Body weight, body fat composition, 
      number of oocytes collected following ovarian superovulation with gonadotropins, 
      ovarian macrophage markers and expression of genes important in folliculogenesis 
      and steroidogenesis were quantified in the 3 groups of animals. Animals in Group 
      2 gained significant body weight and body mass, produced the fewest number of 
      oocytes following superovulation, and had significant alterations in ovarian 
      genes involved in folliculogenesis and steroidogenesis as well as genes involved 
      in inflammation. Although animals in Group 3 had the highest body weight and body 
      fat composition, they produced similar number of oocytes compared to animals in 
      Group 1 but had different ovarian gene expression compared to Group 2. These 
      findings suggest that MCP-1 gene knockout could reverse some of the adverse 
      effects of obesity induced by HF diet intake. Future studies assessing ovarian 
      histology in MCP-1 knock out mouse model will confirm our findings. MCP-1 
      inhibition could represent a future therapeutic target to protect ovarian health 
      from the adverse effects of HF diet ingestion.
FAU - Asemota, Obehi
AU  - Asemota O
AD  - Montefiore's Institute for Reproductive Medicine and Health, Albert Einstein 
      College of Medicine , Hartsdale, NY, USA.
AD  - Albert Einstein College of Medicine , Bronx, NY, USA.
AD  - Currently at Aspire Fertility , Atlanta, GA, USA.
FAU - Thornton, Kimberley
AU  - Thornton K
AD  - Montefiore's Institute for Reproductive Medicine and Health, Albert Einstein 
      College of Medicine , Hartsdale, NY, USA.
AD  - Albert Einstein College of Medicine , Bronx, NY, USA.
AD  - Icahn School of Medicine at Mount Sinai , New York, NY, USA.
FAU - Merhi, Zaher
AU  - Merhi Z
AD  - Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology 
      and Infertility, SUNY Downstate University , Brooklyn, NY, USA.
AD  - Department of Biochemistry, Albert Einstein College of Medicine , Bronx, NY, USA.
FAU - Berger, Dara S
AU  - Berger DS
AD  - Montefiore's Institute for Reproductive Medicine and Health, Albert Einstein 
      College of Medicine , Hartsdale, NY, USA.
AD  - Albert Einstein College of Medicine , Bronx, NY, USA.
AD  - Currently at Department of Obstetrics and Gynecology, University of Pennsylvania 
      , Philadelphia, PA, USA.
FAU - Williams, Lyda
AU  - Williams L
AD  - Department of Biochemistry, Albert Einstein College of Medicine , Bronx, NY, USA.
AD  - Biology Department, Currently at the Lehman College , Bronx, NY, USA.
FAU - Seki, Yoshinori
AU  - Seki Y
AD  - Department of Biochemistry, Albert Einstein College of Medicine , Bronx, NY, USA.
FAU - Du, Xiu Quan
AU  - Du XQ
AD  - Department of Biochemistry, Albert Einstein College of Medicine , Bronx, NY, USA.
FAU - Jindal, Sangita
AU  - Jindal S
AD  - Montefiore's Institute for Reproductive Medicine and Health, Albert Einstein 
      College of Medicine , Hartsdale, NY, USA.
AD  - Albert Einstein College of Medicine , Bronx, NY, USA.
FAU - Charron, Maureen J
AU  - Charron MJ
AD  - Albert Einstein College of Medicine , Bronx, NY, USA.
AD  - Department of Biochemistry, Albert Einstein College of Medicine , Bronx, NY, USA.
AD  - Department of Medicine, Division of Endocrinology, Albert Einstein College of 
      Medicine , Bronx, NY, USA.
FAU - Buyuk, Erkan
AU  - Buyuk E
AD  - Montefiore's Institute for Reproductive Medicine and Health, Albert Einstein 
      College of Medicine , Hartsdale, NY, USA.
AD  - Albert Einstein College of Medicine , Bronx, NY, USA.
AD  - Icahn School of Medicine at Mount Sinai , New York, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20200630
PL  - England
TA  - Syst Biol Reprod Med
JT  - Systems biology in reproductive medicine
JID - 101464963
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
RN  - 0 (Steroids)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - Female
MH  - Macrophages/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Obesity/complications/*etiology/metabolism/prevention & control
MH  - Ovarian Diseases/*etiology/metabolism
MH  - Ovarian Follicle/physiology
MH  - RNA, Messenger/metabolism
MH  - Steroids/metabolism
OTO - NOTNLM
OT  - Monocyte chemotactic protein-1 (MCP-1)
OT  - folliculogenesis
OT  - high-fat diet
OT  - ovarian dysfunction
OT  - steroidogenesis
EDAT- 2020/07/01 06:00
MHDA- 2021/07/20 06:00
CRDT- 2020/07/01 06:00
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2020/07/01 06:00 [entrez]
AID - 10.1080/19396368.2020.1780649 [doi]
PST - ppublish
SO  - Syst Biol Reprod Med. 2020 Aug;66(4):236-243. doi: 10.1080/19396368.2020.1780649. 
      Epub 2020 Jun 30.