PMID- 32604192
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20210506
IS  - 1549-8425 (Electronic)
IS  - 1549-8417 (Linking)
VI  - 16
IP  - 4
DP  - 2020 Dec
TI  - Prevalence and Seriousness of Analgesic-Induced Adverse Events in Korea: A 
      10-Year Nationwide Surveillance.
PG  - e215-e224
LID - 10.1097/PTS.0000000000000742 [doi]
AB  - OBJECTIVES: The objectives of this study were to describe the prevalence and 
      seriousness of analgesic-induced adverse events (AEs) and to identify factors 
      associated with serious analgesic-related AEs in Korea. METHODS: Voluntarily 
      reported analgesic-induced AEs to the Korea Adverse Event Reporting System from 
      2007 to 2016 were retrospectively reviewed. Analgesic medications were classified 
      into nonopioids and opioids based on the Anatomical Therapeutic Chemical 
      classification system. All AEs were grouped using System Organ Classes according 
      to the World Health Organization-Adverse Reaction Terminology. Logistic 
      regression was performed to identify factors associated with serious AEs. 
      RESULTS: Overall, 194,566 AEs (32.2% for nonopioids, 67.8% for opioids) were 
      included in this analysis. The most common causative nonopioid and opioid 
      analgesics was ketorolac (n = 10,789) and tramadol (n = 53,727), respectively. 
      The most frequent AEs were skin and appendage disorders for nonopioids (31.8%) 
      and gastrointestinal disorders (59.5%) for opioids. Serious AEs occurred in 6102 
      (9.7%) and 3326 (2.5%) cases of the nonopioid and opioid groups, respectively. 
      The most common serious AEs were skin and appendage disorders (33.2%) for 
      nonopioids and neurologic disorders (19.3%) for opioids. Serious AEs were 
      significantly associated with male (odds ratio [OR] = 1.423), advanced age (OR = 
      1.570), certain causality (OR = 2.304), nonopioid analgesics (OR = 4.182), and 
      polypharmacy (OR = 1.009; P <0.001 for all). CONCLUSIONS: In Korea, 
      analgesic-induced AEs are prevalent with opioids more commonly implicated. 
      Tramadol is the most common etiologic medication. Serious AEs are more frequently 
      caused by nonopioids with skin and appendage disorders most common.
FAU - Choi, Yeo Jin
AU  - Choi YJ
AD  - From the Clinical Trial Center, Hallym University Sacred Hospital, Anyang, 
      Gyeonggi-do.
FAU - Kim, Myoung-Hee
AU  - Kim MH
AD  - Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul.
FAU - Chung, Eun Kyoung
AU  - Chung EK
FAU - Lee, Jun Kyu
AU  - Lee JK
AD  - Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, 
      Gyeonggi-do, South Korea.
FAU - Yoon, Jimin
AU  - Yoon J
FAU - Yug, Ji Seob
AU  - Yug JS
AD  - Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul.
FAU - Jang, Dong Kee
AU  - Jang DK
AD  - Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, 
      Gyeonggi-do, South Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Patient Saf
JT  - Journal of patient safety
JID - 101233393
RN  - 0 (Analgesics)
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analgesics/*adverse effects
MH  - Analgesics, Opioid/*adverse effects
MH  - Child
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Republic of Korea
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2020/07/01 06:00
MHDA- 2021/02/23 06:00
CRDT- 2020/07/01 06:00
PHST- 2020/07/01 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2020/07/01 06:00 [entrez]
AID - 01209203-202012000-00019 [pii]
AID - 10.1097/PTS.0000000000000742 [doi]
PST - ppublish
SO  - J Patient Saf. 2020 Dec;16(4):e215-e224. doi: 10.1097/PTS.0000000000000742.