PMID- 32606188 OWN - NLM STAT- MEDLINE DCOM- 20210618 LR - 20220531 IS - 1791-7549 (Electronic) IS - 0258-851X (Print) IS - 0258-851X (Linking) VI - 34 IP - 4 DP - 2020 Jul-Aug TI - Serum CEA and CYFRA Levels in ALK-rearranged NSCLC Patients: Correlation With Distant Metastasis. PG - 2095-2100 LID - 10.21873/invivo.12013 [doi] AB - AIM: To clarify the correlation between serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) and metastasis and survival in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: CEA and CYFRA levels in 131 ALK-rearranged NSCLC patients were determined using fluorescence in situ hybridization (FISH), real time-reverse transcription polymerase chain reaction, and immunohistochemistry, using biopsy specimens, cytology specimens, and plasma specimens. Cut-off value of each marker was determined as 10 ng/ml. RESULTS: In logistic regression analysis, higher levels of both markers had a positive relationship with bone metastases, and higher levels of CYFRA was relevant to liver metastases, and multiple-organ metastases. However, these markers were not proven to be poor prognostic factors in Cox's proportional model analysis. CONCLUSION: Elevated serum CEA and CYFRA levels seem to provide useful clinical information about presence of bone and liver metastasis and multiple-organ metastases, although they were not a powerful indicator of prognosis. These two markers may suggest the extension of metastasis and would be helpful in considering treatment options. CI - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. FAU - Numata, Takeshi AU - Numata T AD - Division of Respiratory Medicine, Mito Medical Center, Ibaraki-machi, Japan. FAU - Endo, Takeo AU - Endo T AD - Division of Respiratory Medicine, Mito Medical Center, Ibaraki-machi, Japan. FAU - Yanai, Hidetoshi AU - Yanai H AD - Division of Respiratory Medicine, Mito Medical Center, Ibaraki-machi, Japan. FAU - Ota, Kyoko AU - Ota K AD - Division of Respiratory Medicine, Mito Medical Center, Ibaraki-machi, Japan. FAU - Yamamoto, Yusuke AU - Yamamoto Y AD - Division of Respiratory Medicine, Hitachi General Hospital, Hitachi, Japan. FAU - Shimizu, Kei AU - Shimizu K AD - Division of Respiratory Medicine, Hitachi General Hospital, Hitachi, Japan. FAU - Yamada, Hideyasu AU - Yamada H AD - Division of Respiratory Medicine, Hitachinaka Medical Center-Hitachinaka Medical Center, University of Tsukuba, Hitachinaka, Japan. FAU - Hayashihara, Kenji AU - Hayashihara K AD - Division of Respiratory Medicine, Ibarakihigashi Hospital, Tokai, Japan. FAU - Okauchi, Shinichiro AU - Okauchi S AD - Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan. FAU - Satoh, Hiroaki AU - Satoh H AD - Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan hirosato@md.tsukuba.ac.jp. FAU - Yamada, Yutaka AU - Yamada Y AD - Respiratory Center, Ibaraki Prefectural Central Hospital, Kasama, Japan. FAU - Tamura, Tomohiro AU - Tamura T AD - Respiratory Center, Ibaraki Prefectural Central Hospital, Kasama, Japan. FAU - Saito, Kazuto AU - Saito K AD - Division of Respiratory Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan. FAU - Kikuchi, Norihiro AU - Kikuchi N AD - Division of Respiratory Medicine, Kasumigaura Medical Center Hospital, Tsuchiura, Japan. FAU - Kurishima, Koichi AU - Kurishima K AD - Division of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan. FAU - Ishikawa, Hiroichi AU - Ishikawa H AD - Division of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan. FAU - Watanabe, Hiroko AU - Watanabe H AD - Division of Thoracic Surgery, Tsukuba Kinen Hospital, Tsukuba, Japan. FAU - Shiozawa, Toshihiro AU - Shiozawa T AD - Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. FAU - Hizawa, Nobuyuki AU - Hizawa N AD - Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. FAU - Funayama, Yasunori AU - Funayama Y AD - Division of Respiratory Medicine, Tsukuba Gakuen General Hospital, Tsukuba, Japan. FAU - Hayashi, Shigen AU - Hayashi S AD - Division of Respiratory Medicine, Ibaraki Seinan Medical Center Hospital, Sakai-machi, Japan. FAU - Nakamura, Hiroyuki AU - Nakamura H AD - Division of Respiratory Medicine, Tokyo Medical University, Ibaraki Medical Center, Ami-machi, Japan. FAU - Yamashita, Takaaki AU - Yamashita T AD - Division of Respiratory Medicine, JA Toride Medical Center Hospital, Toride, Japan. LA - eng PT - Journal Article PL - Greece TA - In Vivo JT - In vivo (Athens, Greece) JID - 8806809 RN - 0 (Antigens, Neoplasm) RN - 0 (Biomarkers, Tumor) RN - 0 (Carcinoembryonic Antigen) RN - 0 (KRT19 protein, human) RN - 0 (Keratin-19) RN - 0 (Peptide Fragments) RN - 68238-35-7 (Keratins) RN - EC 2.7.10.1 (Anaplastic Lymphoma Kinase) SB - IM MH - Anaplastic Lymphoma Kinase/genetics MH - Antigens, Neoplasm/genetics MH - Biomarkers, Tumor/genetics MH - Carcinoembryonic Antigen/genetics MH - *Carcinoma, Non-Small-Cell Lung/genetics MH - Humans MH - In Situ Hybridization, Fluorescence MH - Keratin-19 MH - Keratins MH - *Lung Neoplasms/genetics MH - Peptide Fragments MH - Prognosis PMC - PMC7439905 OTO - NOTNLM OT - ALK rearranged NSCLC OT - CEA OT - CYFRA OT - Serum tumor markers OT - carcinoembryonic antigen OT - cytokeratin 19 fragment OT - distant metastasis OT - non-small cell lung cancer COIS- The Authors do not have any conflicts of interest to disclose regarding this study. EDAT- 2020/07/02 06:00 MHDA- 2021/06/22 06:00 PMCR- 2020/07/03 CRDT- 2020/07/02 06:00 PHST- 2020/03/10 00:00 [received] PHST- 2020/03/31 00:00 [revised] PHST- 2020/04/01 00:00 [accepted] PHST- 2020/07/02 06:00 [entrez] PHST- 2020/07/02 06:00 [pubmed] PHST- 2021/06/22 06:00 [medline] PHST- 2020/07/03 00:00 [pmc-release] AID - 34/4/2095 [pii] AID - 10.21873/invivo.12013 [doi] PST - ppublish SO - In Vivo. 2020 Jul-Aug;34(4):2095-2100. doi: 10.21873/invivo.12013.