PMID- 32606444
OWN - NLM
STAT- MEDLINE
DCOM- 20201208
LR  - 20210630
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jun 30
TI  - Benefit of diverse surgical approach on short-term outcomes of MEN1-related 
      hyperparathyroidism.
PG  - 10634
LID - 10.1038/s41598-020-67424-5 [doi]
LID - 10634
AB  - Surgical excision is the preferred treatment for multiple endocrine neoplasia 
      type 1 (MEN1)-related primary hyperparathyroidism (PHPT), although controversy 
      regarding the surgical strategy exists. We retrospectively investigated the 
      short-term outcomes of PHPT by various surgical extents. Thirty-three patients 
      who underwent parathyroidectomy due to MEN1-related PHPT at Yonsei Severance 
      Hospital between 2005 and 2018 were included (age [mean +/- SD], 43.4 +/- 14.1 
      [range, 23-81] years). Total parathyroidectomy with auto-transplantation to the 
      forearm (TPX) was the most common surgical method (17/33), followed by 
      less-than-subtotal parathyroidectomy (LPX; 12/33) and subtotal parathyroidectomy 
      (SPX; 4/33). There was no postoperative persistent hyperparathyroidism. 
      Recurrence was high in the LPX group without significance (1 in TPX, 2 in SPX, 
      and 3 in LPX, p = 0.076). Permanent and transient hypoparathyroidism were more 
      common in TPX (n = 6/17, 35.3%, p = 0.031; n = 4/17, 23.5%, p = 0.154, 
      respectively). Parathyroid venous sampling (PVS) was introduced in 2013 for 
      preoperative localisation of hyperparathyroidism at our hospital; nine among 19 
      patients operated on after 2013 underwent pre-parathyroidectomy PVS, with various 
      surgical extents, and no permanent hypoparathyroidism (p = 0.033) or post-LPX 
      recurrence was observed. Although TPX with auto-transplantation is the standard 
      surgery for MEN1-related PHPT, surgical extent individualisation is necessary, 
      given the postoperative hypoparathyroidism rate of TPX and feasibility of PVS.
FAU - Choi, Hye Ryeon
AU  - Choi HR
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Choi, Sun Hyung
AU  - Choi SH
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Choi, Soon Min
AU  - Choi SM
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Kim, Jin Kyong
AU  - Kim JK
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Lee, Cho Rok
AU  - Lee CR
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Kang, Sang-Wook
AU  - Kang SW
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Lee, Jandee
AU  - Lee J
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Jeong, Jong Ju
AU  - Jeong JJ
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea. jungjongj@yuhs.ac.
FAU - Nam, Kee-Hyun
AU  - Nam KH
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Chung, Woong Youn
AU  - Chung WY
AD  - Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, 
      Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Lee, Seunghyun
AU  - Lee S
AD  - Department of Internal Medicine, Yonsei University College of Medicine, 50 
      Yonsei-ro, Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Hong, Namki
AU  - Hong N
AD  - Department of Internal Medicine, Yonsei University College of Medicine, 50 
      Yonsei-ro, Seodaemun-gu, 03722, Seoul, Republic of Korea.
FAU - Rhee, Yumie
AU  - Rhee Y
AD  - Department of Internal Medicine, Yonsei University College of Medicine, 50 
      Yonsei-ro, Seodaemun-gu, 03722, Seoul, Republic of Korea. yumie@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20200630
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism/etiology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/complications/*surgery
MH  - Parathyroidectomy/adverse effects/*methods
MH  - Postoperative Complications/*epidemiology
PMC - PMC7326992
COIS- The authors declare no competing interests.
EDAT- 2020/07/02 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/06/30
CRDT- 2020/07/02 06:00
PHST- 2020/04/01 00:00 [received]
PHST- 2020/06/09 00:00 [accepted]
PHST- 2020/07/02 06:00 [entrez]
PHST- 2020/07/02 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/06/30 00:00 [pmc-release]
AID - 10.1038/s41598-020-67424-5 [pii]
AID - 67424 [pii]
AID - 10.1038/s41598-020-67424-5 [doi]
PST - epublish
SO  - Sci Rep. 2020 Jun 30;10(1):10634. doi: 10.1038/s41598-020-67424-5.