PMID- 32607132
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 12
DP  - 2020
TI  - The potential therapeutic effects of Lactobacillus plantarum and inulin on serum 
      and testicular reproductive markers in diabetic male rats.
PG  - 53
LID - 10.1186/s13098-020-00560-0 [doi]
LID - 53
AB  - BACKGROUND: It is well established that diminished reproductive health is one of 
      the notable long-term outcomes of type 2 diabetes mellitus (T2DM), especially 
      among males. Due to the global increasing rate of T2DM and infertility, we aimed 
      to investigate the impact of Lactobacillus plantarum (L. plantarum), inulin, and 
      their combinatory supplementation on fertility markers as well as testicular 
      kisspeptin and androgen receptor (AR)'s expression in diabetic male rats. 
      METHODS: Thirty-five Male Wistar rats with Streptozotocin-induced T2DM were 
      supplemented with L. plantarum, inulin, or their combination for 8 weeks. At the 
      end-point, the animals were sacrificed and serum, testicular, and seminal 
      parameters were studied. RESULTS: Administration of L. plantarum and inulin in 
      diabetic male rats improved sperm motility and viability (P < 0.001, both) as 
      well as testicular tissue development via increasing leydig cell number, 
      testicular spermatid count, and diameter of seminiferous tubules (P < 0.001, 
      all). Testicular expression of Kisspeptin was elevated by inulin supplementation 
      (P = 0.01). L. plantarum administration increased testicular AR expression 
      (P = 0.01). The expression of Kisspeptin showed a remarkable correlation with 
      fertility markers (P < 0.001). CONCLUSION: Supplementation with either L. 
      plantarum, inulin, or their combination can prevent infertility caused by T2DM in 
      male rats via improving testicular kisspeptin and AR expression, leydig cell 
      count, and effectively increasing epididymal sperm motility and viability.
CI  - (c) The Author(s) 2020.
FAU - Rahimiyan-Heravan, Marziyeh
AU  - Rahimiyan-Heravan M
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. 
      GRID: grid.412888.f. ISNI: 0000 0001 2174 8913
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. GRID: grid.412888.f. ISNI: 0000 0001 2174 8913
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. GRID: grid.412888.f. ISNI: 0000 
      0001 2174 8913
FAU - Roshangar, Leila
AU  - Roshangar L
AD  - Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 
      GRID: grid.412888.f. ISNI: 0000 0001 2174 8913
FAU - Karimi, Pouran
AU  - Karimi P
AD  - Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. GRID: grid.412888.f. ISNI: 0000 0001 2174 8913
FAU - Sefidgari-Abrasi, Safa
AU  - Sefidgari-Abrasi S
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. 
      GRID: grid.412888.f. ISNI: 0000 0001 2174 8913
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. GRID: grid.412888.f. ISNI: 0000 
      0001 2174 8913
FAU - Morshedi, Mohammad
AU  - Morshedi M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. GRID: grid.412888.f. ISNI: 0000 0001 2174 8913
FAU - Saghafi-Asl, Maryam
AU  - Saghafi-Asl M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. GRID: grid.412888.f. ISNI: 0000 0001 2174 8913
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. GRID: grid.412888.f. ISNI: 0000 
      0001 2174 8913
AD  - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Science, Tabriz, Iran. GRID: grid.412888.f. ISNI: 0000 0001 
      2174 8913
FAU - Bavafa-Valenlia, Khadijeh
AU  - Bavafa-Valenlia K
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. GRID: grid.412888.f. ISNI: 0000 
      0001 2174 8913
LA  - eng
PT  - Journal Article
DEP - 20200626
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC7318432
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Infertility
OT  - Inulin
OT  - Kisspeptin
OT  - Lactobacillus plantarum
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2020/07/02 06:00
MHDA- 2020/07/02 06:01
PMCR- 2020/06/26
CRDT- 2020/07/02 06:00
PHST- 2020/01/22 00:00 [received]
PHST- 2020/06/16 00:00 [accepted]
PHST- 2020/07/02 06:00 [entrez]
PHST- 2020/07/02 06:00 [pubmed]
PHST- 2020/07/02 06:01 [medline]
PHST- 2020/06/26 00:00 [pmc-release]
AID - 560 [pii]
AID - 10.1186/s13098-020-00560-0 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2020 Jun 26;12:53. doi: 10.1186/s13098-020-00560-0. 
      eCollection 2020.