PMID- 32607345
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 8
IP  - 12
DP  - 2020 Jun 26
TI  - Comprehensive treatment of rare multiple endocrine neoplasia type 1: A case 
      report.
PG  - 2647-2654
LID - 10.12998/wjcc.v8.i12.2647 [doi]
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary 
      disorder caused by mutations of the MEN1 gene. It is characterized by 
      hyperparathyroidism and involves the pancreas, anterior pituitary, duodenum, and 
      adrenal gland. Here, we report a 40-year-old male patient with MEN1 who first 
      manifested as thymic carcinoid, then primary hyperparathyroidism and 
      prolactinoma, and a decade later pancreatic neuroendocrine tumor. CASE SUMMARY: 
      The patient underwent a thymectomy because of the thymic carcinoid 10 years prior 
      and a prolactinoma resection 2 years prior. His sister suffered from 
      prolactinoma. His parents displayed a typical triad of amenorrhea, galactorrhea, 
      and infertility. Computed tomography revealed a strong signal in the upper 
      portion of the left lobes and posterior portion of the right lobes of the thyroid 
      and irregular soft tissue densities of the pancreatic body. Positron emission 
      tomography/computed tomography imaging further showed strong 
      (18)F-flurodeoxyglucose uptake in the tail of the pancreatic body and segment IV 
      of the liver. The patient underwent pancreatic body tail resection, pancreatic 
      head mass enucleation, and ultrasound-guided radio-frequency ablation for liver 
      cancer. Pathology results reported neuroendocrine tumor grade 2. Whole exome 
      sequencing revealed a verified pathogenic mutation c.378G>A (p.Trp126*) in the 
      MEN1 gene. The diagnosis of MEN1 was confirmed. At the 1.5-year follow-up, the 
      patient appeared healthy without any sign of reoccurrence. CONCLUSION: The 
      present case may add some insight into the diagnosis and treatment of patients 
      with MEN1.
CI  - (c)The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Ma, Chen-Hui
AU  - Ma CH
AD  - Department of Hepatobiliary, Hebei General Hospital, Shijiazhuang 050017, Hebei 
      Province, China.
FAU - Guo, Huai-Bin
AU  - Guo HB
AD  - Department of Hepatobiliary, Hebei General Hospital, Shijiazhuang 050017, Hebei 
      Province, China.
FAU - Pan, Xin-Yan
AU  - Pan XY
AD  - Department of Hepatobiliary, Hebei General Hospital, Shijiazhuang 050017, Hebei 
      Province, China.
FAU - Zhang, Wan-Xing
AU  - Zhang WX
AD  - Department of Hepatobiliary, Hebei General Hospital, Shijiazhuang 050017, Hebei 
      Province, China. zhangwx12@hotmail.com.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC7322426
OTO - NOTNLM
OT  - Case report
OT  - Multiple endocrine neoplasia type 1
OT  - Neuroendocrine tumor
OT  - Pancreas
OT  - Thymic carcinoid
OT  - Tumor
COIS- Conflict-of-interest statement: We declare that we have no conflict of interest.
EDAT- 2020/07/02 06:00
MHDA- 2020/07/02 06:01
PMCR- 2020/06/26
CRDT- 2020/07/02 06:00
PHST- 2020/01/14 00:00 [received]
PHST- 2020/04/25 00:00 [revised]
PHST- 2020/05/29 00:00 [accepted]
PHST- 2020/07/02 06:00 [entrez]
PHST- 2020/07/02 06:00 [pubmed]
PHST- 2020/07/02 06:01 [medline]
PHST- 2020/06/26 00:00 [pmc-release]
AID - 10.12998/wjcc.v8.i12.2647 [doi]
PST - ppublish
SO  - World J Clin Cases. 2020 Jun 26;8(12):2647-2654. doi: 10.12998/wjcc.v8.i12.2647.