PMID- 32607492
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2574-2531 (Electronic)
IS  - 2574-2531 (Linking)
VI  - 3
IP  - 1
DP  - 2020 Apr
TI  - Mining reported adverse events induced by potential opioid-drug interactions.
PG  - 104-112
LID - 10.1093/jamiaopen/ooz073 [doi]
AB  - OBJECTIVE: Opioid-based analgesia is routinely used in clinical practice for the 
      management of pain and alleviation of suffering at the end of life. It is 
      well-known that opioid-based medications can be highly addictive, promoting not 
      only abuse but also life-threatening overdoses. The scope of opioid-related 
      adverse events (AEs) beyond these well-known effects remains poorly described. 
      This exploratory analysis investigates potential AEs from drug-drug interactions 
      between opioid and nonopioid medications (ODIs). MATERIALS AND METHODS: In this 
      study, we conduct an initial exploration of the association between ODIs and 
      severe AEs using millions of AE reports available in FDA Adverse Event Reporting 
      System (FAERS). The odds ratio (OR)-based analysis and visualization are proposed 
      for single drugs and pairwise ODIs to identify associations between AEs and ODIs 
      of interest. Moreover, the multilabel (multi-AE) learning models are employed to 
      evaluate the feasibility of AE prediction of polypharmacy. RESULTS: The top 12 
      most prescribed opioids in the FAERS are identified. The OR-based analysis 
      identifies a diverse set of AEs associated with individual opioids. Moreover, the 
      results indicate many ODIs can increase the risk of severe AEs dramatically. The 
      area under the curve values of multilabel learning models of ODIs for oxycodone 
      varied between 0.81 and 0.88 for 5 severe AEs. CONCLUSIONS: The proposed data 
      analysis and visualization are useful for mining FAERS data to identify novel 
      polypharmacy associated AEs, as shown for ODIs. This approach was successful in 
      recapitulating known drug interactions and also identified new opioid-specific 
      AEs that could impact prescribing practices.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      American Medical Informatics Association.
FAU - Chen, Jinzhao
AU  - Chen J
AD  - Department of Biostatistics, The Ohio State University, Columbus, Ohio, USA.
FAU - Wu, Gaoyu
AU  - Wu G
AD  - Institute for Informatics (I2), Washington University School of Medicine, 
      Washington University in St. Louis, St. Louis, Missouri, USA.
FAU - Michelson, Andrew
AU  - Michelson A
AD  - Institute for Informatics (I2), Washington University School of Medicine, 
      Washington University in St. Louis, St. Louis, Missouri, USA.
FAU - Vesoulis, Zachary
AU  - Vesoulis Z
AD  - Department of Pediatrics, Washington University School of Medicine, Washington 
      University in St. Louis, St. Louis, Missouri, USA.
FAU - Bogner, Jennifer
AU  - Bogner J
AD  - Department of Physical Medicine and Rehabilitation, The Ohio State University, 
      Columbus, Ohio, USA.
FAU - Corrigan, John D
AU  - Corrigan JD
AD  - Department of Physical Medicine and Rehabilitation, The Ohio State University, 
      Columbus, Ohio, USA.
FAU - Payne, Philip R O
AU  - Payne PRO
AUID- ORCID: 0000-0002-9532-2998
AD  - Institute for Informatics (I2), Washington University School of Medicine, 
      Washington University in St. Louis, St. Louis, Missouri, USA.
FAU - Li, Fuhai
AU  - Li F
AUID- ORCID: 0000-0002-3773-146X
AD  - Institute for Informatics (I2), Washington University School of Medicine, 
      Washington University in St. Louis, St. Louis, Missouri, USA.
AD  - Department of Pediatrics, Washington University School of Medicine, Washington 
      University in St. Louis, St. Louis, Missouri, USA.
LA  - eng
PT  - Journal Article
DEP - 20200426
PL  - United States
TA  - JAMIA Open
JT  - JAMIA open
JID - 101730643
PMC - PMC7309259
OTO - NOTNLM
OT  - adverse drug effects
OT  - opioid
OT  - opioid-drug interaction
EDAT- 2020/07/02 06:00
MHDA- 2020/07/02 06:01
PMCR- 2020/04/26
CRDT- 2020/07/02 06:00
PHST- 2019/08/13 00:00 [received]
PHST- 2019/12/17 00:00 [revised]
PHST- 2020/03/02 00:00 [accepted]
PHST- 2020/07/02 06:00 [entrez]
PHST- 2020/07/02 06:00 [pubmed]
PHST- 2020/07/02 06:01 [medline]
PHST- 2020/04/26 00:00 [pmc-release]
AID - ooz073 [pii]
AID - 10.1093/jamiaopen/ooz073 [doi]
PST - epublish
SO  - JAMIA Open. 2020 Apr 26;3(1):104-112. doi: 10.1093/jamiaopen/ooz073. eCollection 
      2020 Apr.