PMID- 32607795
OWN - NLM
STAT- MEDLINE
DCOM- 20210602
LR  - 20210730
IS  - 1432-5195 (Electronic)
IS  - 0341-2695 (Linking)
VI  - 45
IP  - 5
DP  - 2021 May
TI  - Association of the matrix metalloproteinase 3 (MMP3) single nucleotide 
      polymorphisms with tendinopathies: case-control study in high-level athletes.
PG  - 1163-1168
LID - 10.1007/s00264-020-04684-w [doi]
AB  - BACKGROUND: Matrix metalloproteinases (MMPs) play an important role in matrix 
      remodelling, as well as in tendon integrity. Due to overuse, athletes often 
      develop chronic tendinopathies. If not treated, they lead to severe impairment, 
      even complete tendon ruptures. AIM: The main purpose of this study was to 
      investigate whether three functional polymorphisms within the MMP3 gene are 
      associated with increased risk of developing tendinopathies in high-level 
      Croatian athletes. METHODS: We have recruited one hundred fifty-five (63 
      high-level athletes with diagnosed tendinopathies and 92 asymptomatic controls) 
      unrelated Caucasians for this case-control genetic study. All participants were 
      genotyped for three single nucleotide polymorphisms (SNP) within the MMP3 gene: 
      rs591058 C/T, rs650108 A/G and rs679620 G/A using the pyrosequencing method. 
      RESULTS: The MMP3 rs650108 GG (P = 0.0074) and rs679620 AA (P = 0.0119) genotypes 
      were significantly over-represented in cases compared with controls, while 
      rs591058 TT (P = 0.0759), as well as haplotype variant T - G - A (P = 0.06), 
      implicated that there is an indication of predisposition for tendinopathies. 
      CONCLUSION: These results support association between functional variants within 
      the MMP3 gene and the risk of tendinopathies in high-level athletes. Further 
      research is needed to replicate these results in a larger population.
FAU - Briski, Nina
AU  - Briski N
AUID- ORCID: 0000-0003-3802-5142
AD  - Genos Ltd, Borongajska cesta 83h, 10000, Zagreb, Croatia. nbriski@genos.hr.
AD  - Faculty of Kinesiology, University of Zagreb, Horvacanski zavoj 15, 10000, 
      Zagreb, Croatia. nbriski@genos.hr.
FAU - Vrgoc, Goran
AU  - Vrgoc G
AUID- ORCID: 0000-0002-4541-4659
AD  - Faculty of Kinesiology, University of Zagreb, Horvacanski zavoj 15, 10000, 
      Zagreb, Croatia.
AD  - Department of Orthopaedic Surgery, University Hospital, "Sveti Duh", Ulica Sveti 
      Duh 64, 10000, Zagreb, Croatia.
FAU - Knjaz, Damir
AU  - Knjaz D
AUID- ORCID: 0000-0001-9080-2151
AD  - Faculty of Kinesiology, University of Zagreb, Horvacanski zavoj 15, 10000, 
      Zagreb, Croatia.
FAU - Jankovic, Sasa
AU  - Jankovic S
AUID- ORCID: 0000-0002-2573-2932
AD  - Faculty of Kinesiology, University of Zagreb, Horvacanski zavoj 15, 10000, 
      Zagreb, Croatia.
AD  - Department of Orthopaedic Surgery, University Hospital, "Sveti Duh", Ulica Sveti 
      Duh 64, 10000, Zagreb, Croatia.
FAU - Ivkovic, Alan
AU  - Ivkovic A
AUID- ORCID: 0000-0003-0236-6244
AD  - Department of Orthopaedic Surgery, University Hospital, "Sveti Duh", Ulica Sveti 
      Duh 64, 10000, Zagreb, Croatia.
AD  - School of Medicine, University of Zagreb, Salata 2, 10000, Zagreb, Croatia.
AD  - Department of Biotechnology, University of Rijeka, Ulica Radmile Matejcic 2, 
      51000, Rijeka, Croatia.
FAU - Pecina, Marko
AU  - Pecina M
AUID- ORCID: 0000-0002-8537-1761
AD  - School of Medicine, University of Zagreb, Salata 2, 10000, Zagreb, Croatia.
FAU - Lauc, Gordan
AU  - Lauc G
AUID- ORCID: 0000-0003-1840-9560
AD  - Genos Ltd, Borongajska cesta 83h, 10000, Zagreb, Croatia.
AD  - Faculty of Pharmacy and Biochemistry, University of Zagreb, Ulica Ante Kovacica 
      1, 10000, Zagreb, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20200630
PL  - Germany
TA  - Int Orthop
JT  - International orthopaedics
JID - 7705431
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Athletes
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - *Matrix Metalloproteinase 3/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - *Tendinopathy/epidemiology/genetics
OTO - NOTNLM
OT  - Achilles tendinopathy
OT  - Genetic association study
OT  - Matrix metalloproteinase 3 (MMP3)
OT  - Single nucleotide polymorphism
OT  - Sport injury
EDAT- 2020/07/02 06:00
MHDA- 2021/06/03 06:00
CRDT- 2020/07/02 06:00
PHST- 2020/04/14 00:00 [received]
PHST- 2020/06/22 00:00 [accepted]
PHST- 2020/07/02 06:00 [pubmed]
PHST- 2021/06/03 06:00 [medline]
PHST- 2020/07/02 06:00 [entrez]
AID - 10.1007/s00264-020-04684-w [pii]
AID - 10.1007/s00264-020-04684-w [doi]
PST - ppublish
SO  - Int Orthop. 2021 May;45(5):1163-1168. doi: 10.1007/s00264-020-04684-w. Epub 2020 
      Jun 30.