PMID- 32609340
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20211119
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 47
IP  - 1
DP  - 2021 Jan 23
TI  - Neurophysiological Correlate of Emotion Regulation by Cognitive Reappraisal and 
      Its Association With Psychotic Symptoms in Early Psychosis.
PG  - 87-96
LID - 10.1093/schbul/sbaa080 [doi]
AB  - BACKGROUND: Emotion dysregulation is crucial to both poor social functioning and 
      psychotic symptom formation in patients with schizophrenia. The efficient use of 
      emotion regulation strategies, such as cognitive reappraisal, has been less 
      frequently observed in the early phases of psychotic disorder. It is unknown 
      whether neurophysiological responses related to emotion regulation by cognitive 
      reappraisal are altered in early psychosis. METHODS: Fifty-four patients with 
      first-episode psychosis (FEP), 34 subjects at clinical high risk (CHR) for 
      psychosis, and 30 healthy controls (HCs) participated in event-related potential 
      recordings during a validated emotion regulation paradigm to measure the effect 
      of cognitive reappraisal on emotion regulation. Late positive potentials (LPPs), 
      which reflect emotional arousal, were compared across the groups and the 3 
      conditions (negative, cognitive reappraisal, and neutral). The relationship among 
      LPP modulation by cognitive reappraisal and social/role functioning and severity 
      of psychotic symptoms was investigated in the early psychosis group. RESULTS: The 
      FEP and CHR participants showed comparably larger LPP amplitudes in the negative 
      and cognitive reappraisal conditions than in the neutral condition, whereas the 
      HCs presented larger LPPs in the negative condition than in the cognitive 
      reappraisal and neutral conditions. LPP modulation by cognitive reappraisal was 
      negatively correlated with positive symptom severity in the FEP patients and with 
      disorganization severity in the CHR subjects. CONCLUSIONS: Inefficient use of 
      cognitive reappraisal may be related to the impaired emotion regulation and 
      psychotic symptoms from the very beginning of psychotic disorder. This study 
      provides the first neurophysiological evidence regarding current concepts of 
      emotion regulation in early psychosis.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center. All rights reserved. For permissions, 
      please email: journals.permissions@oup.com.
FAU - Kim, Minah
AU  - Kim M
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Hwang, Wu Jeong
AU  - Hwang WJ
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Park, Jihye
AU  - Park J
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Kim, Taekwan
AU  - Kim T
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Oh, Sanghoon
AU  - Oh S
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
AD  - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Affective Symptoms/etiology/*physiopathology
MH  - Disease Susceptibility
MH  - Electroencephalography
MH  - Emotional Regulation/*physiology
MH  - Evoked Potentials/*physiology
MH  - Humans
MH  - Judgment/*physiology
MH  - Psychotic Disorders/complications/*physiopathology
MH  - Risk
MH  - Schizophrenia/complications/*physiopathology
MH  - *Social Perception
MH  - Young Adult
PMC - PMC7825098
OTO - NOTNLM
OT  - clinical high risk
OT  - cognitive reappraisal
OT  - emotion regulation
OT  - first-episode psychosis
OT  - late positive potential
OT  - psychotic symptoms
EDAT- 2020/07/02 06:00
MHDA- 2021/11/20 06:00
PMCR- 2021/07/01
CRDT- 2020/07/02 06:00
PHST- 2020/07/02 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2020/07/02 06:00 [entrez]
PHST- 2021/07/01 00:00 [pmc-release]
AID - 5865791 [pii]
AID - sbaa080 [pii]
AID - 10.1093/schbul/sbaa080 [doi]
PST - ppublish
SO  - Schizophr Bull. 2021 Jan 23;47(1):87-96. doi: 10.1093/schbul/sbaa080.