PMID- 32610105
OWN - NLM
STAT- MEDLINE
DCOM- 20210309
LR  - 20210309
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 332
DP  - 2020 Oct
TI  - Protective effects of FGF10 on neurovascular unit in a rat model of neonatal 
      hypoxic-ischemic brain injury.
PG  - 113393
LID - S0014-4886(20)30224-7 [pii]
LID - 10.1016/j.expneurol.2020.113393 [doi]
AB  - Neonatal hypoxic-ischemic (HI) brain injury remains a devastating clinical 
      disease associated with high mortality and lifetime disability. Neonatal HI 
      injury damages the architecture of neurovascular unit (NVU), thus, therapy 
      targeting the NVU may provide effective neuroprotection against HI. This study 
      was designed to investigate whether fibroblast growth factor 10 (FGF10) protected 
      the NVU against HI and afforded observable neuroprotection in a rat model of 
      neonatal HI brain injury. The results showed that FGF10 treatment significantly 
      reduced brain damage post HI, characterized by reduction in brain infarct volume 
      and tissue loss. Further interesting findings showed that FGF10 treatment exerted 
      neuroprotective effects on HI brain injury in neonate rats through protecting the 
      NVU against HI, evidenced by inhibition of neuronal cell apoptosis, suppression 
      of gliosis, and amelioration of blood-brain barrier disruption. Collectively, our 
      study indicates that FGF10 treatment exhibits great potential for protecting NVU 
      against HI and attenuates neonatal brain injury, suggesting a potential novel 
      therapeutic agent to this disease.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Fang, Mingchu
AU  - Fang M
AD  - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
FAU - Jiang, Shishuang
AU  - Jiang S
AD  - School of Nursing, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
FAU - Zhu, Jianghu
AU  - Zhu J
AD  - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
FAU - Fu, Xiaoqin
AU  - Fu X
AD  - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
FAU - Hu, Yingying
AU  - Hu Y
AD  - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
FAU - Pan, Shulin
AU  - Pan S
AD  - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
FAU - Jiang, Huai
AU  - Jiang H
AD  - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
FAU - Lin, Jian
AU  - Lin J
AD  - Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
FAU - Yuan, Junhui
AU  - Yuan J
AD  - Department of Neonatology, Wenling Maternal and Child Health Care Hospital, 
      Wenling, Zhejiang 317500, China.
FAU - Li, Peijun
AU  - Li P
AD  - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
FAU - Lin, Zhenlang
AU  - Lin Z
AD  - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's 
      Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Department 
      of Neonatology, Taizhou Maternal and Child Health Care Hospital, Wenzhou Medical 
      University, Taizhou, Zhejiang 318000, China. Electronic address: 
      linzhenlang@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200629
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Fgf10 protein, rat)
RN  - 0 (Fibroblast Growth Factor 10)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Apoptosis/drug effects
MH  - Astrocytes/pathology
MH  - Blood-Brain Barrier/drug effects
MH  - Brain/pathology
MH  - Brain Edema/pathology
MH  - Cerebral Infarction/etiology/prevention & control
MH  - Female
MH  - Fibroblast Growth Factor 10/*pharmacology
MH  - Gliosis/pathology
MH  - Hypoxia-Ischemia, Brain/*drug therapy
MH  - Microglia/pathology
MH  - Neuroprotection
MH  - Neuroprotective Agents/*pharmacology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Fibroblast growth factor 10
OT  - Neonatal hypoxic-ischemic brain injury
OT  - Neuroprotection
OT  - Neurovascular unit
COIS- Declaration of Competing Interest The authors declare that they have no competing 
      interests.
EDAT- 2020/07/02 06:00
MHDA- 2021/03/10 06:00
CRDT- 2020/07/02 06:00
PHST- 2020/04/12 00:00 [received]
PHST- 2020/06/02 00:00 [revised]
PHST- 2020/06/25 00:00 [accepted]
PHST- 2020/07/02 06:00 [pubmed]
PHST- 2021/03/10 06:00 [medline]
PHST- 2020/07/02 06:00 [entrez]
AID - S0014-4886(20)30224-7 [pii]
AID - 10.1016/j.expneurol.2020.113393 [doi]
PST - ppublish
SO  - Exp Neurol. 2020 Oct;332:113393. doi: 10.1016/j.expneurol.2020.113393. Epub 2020 
      Jun 29.