PMID- 32610378
OWN - NLM
STAT- MEDLINE
DCOM- 20200715
LR  - 20200715
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 49
IP  - 7
DP  - 2020 Jul 8
TI  - [Clinicopathological characteristics of pediatric-type follicular lymphomas: an 
      analysis of 37 cases].
PG  - 681-685
LID - 10.3760/cma.j.cn112151-20200214-00096 [doi]
AB  - Objective: To study the clinicopathologic features, immunophenotype and prognosis 
      of pediatric-type follicular lymphoma (PTFL). Methods: Thirty-seven cases of PTFL 
      at the Beijing Friendship Hospital, Capital Medical University, from January 2012 
      to March 2018 were analyzed using light microscopy, immunohistochemistry, and 
      polymerase chain reaction (PCR), and 13 cases were also examined using 
      fluorescence in situ hybridization (FISH). Results: The male to female ratio was 
      35ratio2. The median age was 16 years. Thirty-one patients were clinical stage Ⅰ and 
      6 were stage Ⅱ, displaying enlargement of lymph node in the head and neck 
      regions. Follow-up information was available in 32 patients. Only two patients 
      received low-dose chemotherapy, and none of these patients had relapse or disease 
      progression at the latest follow-up (ranging from 16 to 79 months; median, 37 
      months). Morphologically, the lymph node architecture was partially or totally 
      effaced by expansile follicles lacking polarization, with a prominent "starry 
      sky" appearance. The cytologic composition was dominated by monotonous medium to 
      large-sized blastoid cells with round to oval nuclei, finely clumped chromatin, 
      small nucleoli, and scant cytoplasm. Immunophenotypically, all cases were 
      positive for CD20, CD10, and bcl-6, but negative for bcl-2, MUM1 and C-MYC. Tumor 
      cells were restricted to the follicles. The Ki-67 immunohistochemistry 
      demonstrated a high proliferation (50% to 90%). Moreover, the tumor cells in the 
      examined 28 cases were negative for CD43, CD5 and CD23. PCR analysis revealed 
      monoclonal Ig gene rearrangements in all specimens. Thirteen cases being 
      subjected to the FISH testing lacked bcl-2 and bcl-6 translocations. Conclusion: 
      PTFL is different from conventional follicular lymphoma in their distinct 
      morphology, immunophenotypic and molecular features, and behaves like an highly 
      indolent or benign tumor.
FAU - Zheng, Y Y
AU  - Zheng YY
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
FAU - Xie, J L
AU  - Xie JL
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
FAU - Zhang, Y L
AU  - Zhang YL
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
FAU - Zhou, X G
AU  - Zhou XG
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Adolescent
MH  - Female
MH  - Genes, myc
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - *Lymphoma, Follicular
MH  - Male
OTO - NOTNLM
OT  - Diagnosis, differential
OT  - Lymphoma, B-cell
OT  - Lymphoma, follicular
OT  - Pathology, clinical
EDAT- 2020/07/03 06:00
MHDA- 2020/07/16 06:00
CRDT- 2020/07/02 06:00
PHST- 2020/07/02 06:00 [entrez]
PHST- 2020/07/03 06:00 [pubmed]
PHST- 2020/07/16 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20200214-00096 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2020 Jul 8;49(7):681-685. doi: 
      10.3760/cma.j.cn112151-20200214-00096.