PMID- 32611145
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1520-8524 (Electronic)
IS  - 0001-4966 (Print)
IS  - 0001-4966 (Linking)
VI  - 147
IP  - 6
DP  - 2020 Jun
TI  - A modified mixed domain method for modeling acoustic wave propagation in strongly 
      heterogeneous media.
PG  - 4055
LID - 10.1121/10.0001454 [doi]
AB  - In this paper, phase correction and amplitude compensation are introduced to a 
      previously developed mixed domain method (MDM), which is only accurate for 
      modeling wave propagation in weakly heterogeneous media. Multiple reflections are 
      also incorporated with the one-way model to improve the accuracy. The resulting 
      model is denoted as the modified mixed domain method (MMDM) and is numerically 
      evaluated for its accuracy and efficiency using four distinct cases. It is found 
      that the MMDM is significantly more accurate than the MDM for strongly 
      heterogeneous media, especially when the phase aberrating layer is approximately 
      perpendicular to the acoustic beam. Additionally, a convergence study suggests 
      that the second-order reflection could be sufficient for cases involving high 
      contrast inhomogeneities and large loss values (e.g., skulls). The method 
      developed in this work could facilitate therapeutic ultrasound for treating 
      brain-related diseases and disorders.
FAU - Gu, Juanjuan
AU  - Gu J
AUID- ORCID: s0000000304506386
AD  - Department of Mechanical and Aerospace Engineering, North Carolina State 
      University, Raleigh, North Carolina 27695, USA.
FAU - Jing, Yun
AU  - Jing Y
AUID- ORCID: s0000000329605292
AD  - Department of Mechanical and Aerospace Engineering, North Carolina State 
      University, Raleigh, North Carolina 27695, USA.
LA  - eng
GR  - R01 EB025205/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Acoust Soc Am
JT  - The Journal of the Acoustical Society of America
JID - 7503051
SB  - IM
MH  - *Acoustics
MH  - Computer Simulation
MH  - Skull
MH  - Sound
MH  - *Ultrasonic Therapy
PMC - PMC7311178
EDAT- 2020/07/03 06:00
MHDA- 2021/06/22 06:00
PMCR- 2021/06/01
CRDT- 2020/07/03 06:00
PHST- 2020/07/03 06:00 [entrez]
PHST- 2020/07/03 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 10.0001454 [pii]
AID - 10.1121/10.0001454 [doi]
PST - ppublish
SO  - J Acoust Soc Am. 2020 Jun;147(6):4055. doi: 10.1121/10.0001454.