PMID- 32612024
OWN - NLM
STAT- MEDLINE
DCOM- 20201105
LR  - 20221101
IS  - 1347-3352 (Electronic)
IS  - 1345-8957 (Linking)
VI  - 69
IP  - 7
DP  - 2020
TI  - Two Mixed-ligand Coordination Polymers: Crystal Structures and Protective Effect 
      on Ischemic Stroke by Increasing glp1r Expression.
PG  - 743-750
LID - 10.5650/jos.ess20047 [doi]
AB  - In this study, two new mixed-ligand coordination polymers 
      [Co(bbi)(tdc)].5H(2)O(n) (1, bbi = 1,4-bis(imidazolyl)butane) and 
      [Cu(2)(bimb)(H(2)O)(mu(3)-tdc)(2)(DMF)(2)].H(2)O(n) (2, bimb = 
      4-bis(1H-imidazol-1-yl-methyl)benzene) were synthesized under the solvothermal 
      conditions via reaction of 2,5-thiophenedicarboxylic acid (H(2)tdc) with the 
      corresponding metal salts in the existence of different flexible bis-imidazole 
      ligands (bbi for 1 and bimb for 2). The as-prepared two structures were detected 
      via the single crystal X-ray diffraction (SXRD) and then characterized via the 
      analysis of element, powder X-ray diffraction (PXRD), thermogravimetric analysis 
      (TGA) as well as infrared (IR) spectroscopy. Furthermore, the protective activity 
      of the compound on the mice with ischemic stroke was evaluated. Firstly, the real 
      time reverse transcription-polymerase chain raction (RT-PCR) was carried out to 
      determine the effect of compounds 1 and 2 against the relative expression level 
      of the glucagon-like peptide 1 receptors (glp1r) on the cerebrovascular 
      endothelial cells. Next, the Morris Water Maze Experiment was also used to detect 
      the improvement function of compounds 1 and 2 on the nice mice cognitive 
      function.
FAU - Fang, Xing
AU  - Fang X
AD  - Department of Neurology, Beilun People's Hospital.
FAU - Tong, Ke-Zhen
AU  - Tong KZ
AD  - Department of Pediatrics, Ningbo Yinzhou People's Hospital.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Neurology, Beilun People's Hospital.
FAU - Ni, Hua-Fu
AU  - Ni HF
AD  - Department of Neurology, Beilun People's Hospital.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PL  - Japan
TA  - J Oleo Sci
JT  - Journal of oleo science
JID - 101175339
RN  - 0 (Coordination Complexes)
RN  - 0 (Glp1r protein, mouse)
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 0 (Imidazoles)
RN  - 0 (Ligands)
RN  - 0 (Metals)
RN  - 0 (Polymers)
RN  - 0 (Thiophenes)
RN  - 7GBN705NH1 (imidazole)
SB  - IM
RIN - J Oleo Sci. 2022;71(11):1695. PMID: 36310056
MH  - Animals
MH  - Brain/cytology/*metabolism
MH  - Chemical Phenomena
MH  - Cognition/drug effects
MH  - Coordination Complexes/*chemical synthesis/*pharmacology/therapeutic use
MH  - Crystallization
MH  - Endothelial Cells/metabolism
MH  - Gene Expression/*drug effects
MH  - Glucagon-Like Peptide-1 Receptor/*genetics/*metabolism
MH  - Imidazoles/chemistry
MH  - Ligands
MH  - Maze Learning/drug effects
MH  - Metals/*chemistry
MH  - Mice
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Polymers/*chemical synthesis/chemistry
MH  - Stroke/*drug therapy/*genetics
MH  - Structure-Activity Relationship
MH  - Thiophenes/*chemistry
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - X-ray diffraction
OT  - coordination polymers
OT  - ischemic stroke
OT  - mixed-ligand
EDAT- 2020/07/03 06:00
MHDA- 2020/11/06 06:00
CRDT- 2020/07/03 06:00
PHST- 2020/07/03 06:00 [entrez]
PHST- 2020/07/03 06:00 [pubmed]
PHST- 2020/11/06 06:00 [medline]
AID - 10.5650/jos.ess20047 [doi]
PST - ppublish
SO  - J Oleo Sci. 2020;69(7):743-750. doi: 10.5650/jos.ess20047.