PMID- 32612525
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 12
DP  - 2020
TI  - Aberrant Brain Spontaneous Activity and Synchronization in Type 2 Diabetes 
      Mellitus Patients: A Resting-State Functional MRI Study.
PG  - 181
LID - 10.3389/fnagi.2020.00181 [doi]
LID - 181
AB  - The study aimed to investigate the aberration of brain spontaneous activity and 
      synchronization in type 2 diabetes mellitus (T2DM) patients homozygous for the 
      apolipoprotein E (APOE)-epsilon3 allele. In the APOE-epsilon3 homozygotes, 37 T2DM patients 
      and 37 well-matched healthy controls (HC) were included to acquire blood sample 
      measurements, neuropsychological tests, and brain functional MRI data. The 
      amplitude of low-frequency fluctuations (ALFF) analysis was conducted to identify 
      the brain areas with abnormal spontaneous activity. Then, the identified brain 
      areas were taken as seeds to compute their functional connectivity (FC) with 
      other brain regions. The two-sample t-test or the Mann-Whitney U test were 
      applied to reveal significant differences in acquired measurements between the 
      two groups. The potential correlations among the three types of measurements were 
      explored using partial correlation analysis in the T2DM group. The T2DM group had 
      elevated glycemic levels and scored lower on the cognitive assessment but higher 
      on the anxiety and depression tests (p < 0.05). The T2DM group exhibited higher 
      ALFF in the left middle occipital gyrus, and the left middle occipital gyrus had 
      lower FC with the left caudate nucleus and the left inferior parietal gyrus (p < 
      0.05). No significant correlations were observed. T2DM patients homozygous for 
      the APOE-epsilon3 allele exhibited aberrant brain spontaneous activity and 
      synchronization in brain regions associated with vision-related information 
      processing, executive function, and negative emotions. The findings may update 
      our understanding of the mechanisms of brain dysfunction in T2DM patients in a 
      neuroimaging perspective.
CI  - Copyright (c) 2020 Liu, Duan, Wei, Chen, Wang and Zhang.
FAU - Liu, Daihong
AU  - Liu D
AD  - Department of Medical Imaging, Chongqing University Cancer Hospital, Chongqing, 
      China.
FAU - Duan, Shanshan
AU  - Duan S
AD  - Department of Endocrinology, Southwest Hospital, Third Military Medical 
      University (Army Medical University), Chongqing, China.
FAU - Wei, Ping
AU  - Wei P
AD  - Department of Endocrinology, Southwest Hospital, Third Military Medical 
      University (Army Medical University), Chongqing, China.
FAU - Chen, Lihua
AU  - Chen L
AD  - Department of Radiology, PLA 904 Hospital, Wuxi, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University), Chongqing, China.
FAU - Zhang, Jiuquan
AU  - Zhang J
AD  - Department of Medical Imaging, Chongqing University Cancer Hospital, Chongqing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200616
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC7308457
OTO - NOTNLM
OT  - APOE-epsilon3 homozygotes
OT  - amplitude of low-frequency fluctuations
OT  - functional connectivity
OT  - resting-state functional magnetic resonance imaging
OT  - type 2 diabetes mellitus
EDAT- 2020/07/03 06:00
MHDA- 2020/07/03 06:01
PMCR- 2020/01/01
CRDT- 2020/07/03 06:00
PHST- 2020/03/17 00:00 [received]
PHST- 2020/05/25 00:00 [accepted]
PHST- 2020/07/03 06:00 [entrez]
PHST- 2020/07/03 06:00 [pubmed]
PHST- 2020/07/03 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2020.00181 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2020 Jun 16;12:181. doi: 10.3389/fnagi.2020.00181. 
      eCollection 2020.