PMID- 32612990
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 8
DP  - 2020
TI  - Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future.
PG  - 438
LID - 10.3389/fcell.2020.00438 [doi]
LID - 438
AB  - Cell migration plays a critical role in vascular homeostasis. Under noxious 
      stimuli, endothelial cells (ECs) migration always contributes to vascular repair, 
      while enhanced migration of vascular smooth muscle cells (VSMCs) will lead to 
      pathological vascular remodeling. Moreover, vascular activities are involved in 
      communication between ECs and VSMCs, between ECs and immune cells, et al. 
      Recently, Ma et al. (2015) discovered a novel migration-dependent organelle 
      "migrasome," which mediated release of cytoplasmic contents, and this process was 
      defined as "migracytosis." The formation of migrasome is precisely regulated by 
      tetraspanins (TSPANs), cholesterol and integrins. Migrasomes can be taken up by 
      neighboring cells, and migrasomes are distributed in many kinds of cells and 
      tissues, such as in blood vessel, human serum, and in ischemic brain of human and 
      mouse. In addition, the migrasome elements TSPANs are wildly expressed in 
      cardiovascular system. Therefore, TSPANs, migrasomes and migracytosis might play 
      essential roles in regulating vascular homeostasis. In this review, we will 
      discuss the discoveries of migration-dependent migrasome and migracytosis, 
      migrasome formation, the basic differences between migrasomes and exosomes, the 
      distributions and functions of migrasome, the functions of migrasome elements 
      TSPANs in vascular biology, and discuss the possible roles of migrasomes and 
      migracytosis in vascular homeostasis.
CI  - Copyright (c) 2020 Zhang, Wang, Ding, Zhang, Xu, Xu, Zheng and Yang.
FAU - Zhang, Yaxing
AU  - Zhang Y
AD  - Department of Traditional Chinese Medicine, The Third Affiliated Hospital, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Ophthalmology, Qingdao Fubai Eye Hospital, Qingdao, China.
FAU - Ding, Yungang
AU  - Ding Y
AD  - Department of Ophthalmology, Qingdao Ludong Eye Hospital, Qingdao, China.
FAU - Zhang, Jiongshan
AU  - Zhang J
AD  - Department of Traditional Chinese Medicine, The Third Affiliated Hospital, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Xu, Yan
AU  - Xu Y
AD  - Department of Gastrointestinal Endoscopy, Guangzhou Cadre Health Management 
      Center/Guangzhou Eleventh People's Hospital, Guangzhou, China.
FAU - Xu, Jingting
AU  - Xu J
AD  - Biofeedback Laboratory, Xinhua College of Sun Yat-sen University, Guangzhou, 
      China.
FAU - Zheng, Shuhui
AU  - Zheng S
AD  - Research Center for Translational Medicine, The First Affiliated Hospital, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Yang, Hongzhi
AU  - Yang H
AD  - Department of Traditional Chinese Medicine, The Third Affiliated Hospital, Sun 
      Yat-sen University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200616
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC7308473
OTO - NOTNLM
OT  - cell migration
OT  - migracytosis
OT  - migrasome
OT  - tetraspanins
OT  - vascular homeostasis
EDAT- 2020/07/03 06:00
MHDA- 2020/07/03 06:01
PMCR- 2020/01/01
CRDT- 2020/07/03 06:00
PHST- 2020/03/16 00:00 [received]
PHST- 2020/05/11 00:00 [accepted]
PHST- 2020/07/03 06:00 [entrez]
PHST- 2020/07/03 06:00 [pubmed]
PHST- 2020/07/03 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2020.00438 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2020 Jun 16;8:438. doi: 10.3389/fcell.2020.00438. 
      eCollection 2020.