PMID- 32613536
OWN - NLM
STAT- MEDLINE
DCOM- 20210604
LR  - 20210604
IS  - 2520-8721 (Electronic)
IS  - 1109-3099 (Linking)
VI  - 19
IP  - 3
DP  - 2020 Sep
TI  - Reproductive health in women with type 2 diabetes mellitus.
PG  - 291-300
LID - 10.1007/s42000-020-00225-7 [doi]
AB  - As type 2 diabetes mellitus (T2DM) reaches epidemic proportions in the developed 
      world and the age at diagnosis decreases, more women of reproductive age are 
      being affected. In this article, we provide a synoptic view on potential 
      mechanisms and relevant factors underlying menstrual cycle disorders and 
      fertility issues in women with T2DM. The article discusses the function of the 
      hypothalamic-pituitary-ovarian (HPO) axis, the central role of the hypothalamus 
      in the homeostasis of this system, the central modulators of the axis, and the 
      peripheral metabolic signals involved in neuroendocrine control of reproduction. 
      The available literature on the relationship between T2DM and the female 
      reproductive lifespan, menstrual cycle disorders, fertility issues, and 
      gestational health in women with T2DM are also discussed. The data so far 
      indicate that there is a "U-shaped" relationship between menarche, menopause, and 
      T2DM, both early and late menarche/menopause being risk factors for T2DM. 
      Hyperglycemia and its consequences may be responsible for the effects of T2DM on 
      reproductive health in women, but the exact mechanisms are not as yet fully 
      understood; thus, more studies are needed in order to identify factors causing 
      disruption of the HPO axis.
FAU - Cretu, Doina
AU  - Cretu D
AD  - Mures County Clinical Hospital, 38 Gheorghe Marinescu Street, 540139, 
      Targu-Mures, Romania.
FAU - Cernea, Simona
AU  - Cernea S
AUID- ORCID: 0000-0002-9494-6571
AD  - Department M4/Internal Medicine IV, George Emil Palade University of Medicine, 
      Pharmacy, Science, and Technology of Targu-Mures, 38 Gheorghe Marinescu Street, 
      540139, Targu-Mures, Romania.
AD  - Diabetes, Nutrition and Metabolic Diseases Outpatient Unit, Emergency County 
      Clinical Hospital, 50 Gheorghe Marinescu Street, 540136, Targu-Mures, Romania.
FAU - Onea, Corina Roxana
AU  - Onea CR
AD  - Emergency County Clinical Hospital, 50 Gheorghe Marinescu Street, 540136, 
      Targu-Mures, Romania.
FAU - Pop, Raluca-Monica
AU  - Pop RM
AUID- ORCID: 0000-0003-1243-1855
AD  - Research Methodology Department, George Emil Palade University of Medicine, 
      Pharmacy, Science, and Technology of Targu-Mures, 38 Gheorghe Marinescu Street, 
      540139, Targu-Mures, Romania. raluca.pop@umfst.ro.
AD  - Endocrinology Department, Mures County Clinical Hospital, 38 Gheorghe Marinescu 
      Street, 540139, Targu-Mures, Romania. raluca.pop@umfst.ro.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200702
PL  - Switzerland
TA  - Hormones (Athens)
JT  - Hormones (Athens, Greece)
JID - 101142469
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Diabetes Mellitus, Type 2/complications/etiology/*metabolism
MH  - Female
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/*metabolism
MH  - Infertility, Female/complications/etiology/*metabolism
MH  - Menarche/*metabolism
MH  - Menopause/*metabolism
MH  - Menstruation Disturbances/complications/etiology/*metabolism
MH  - Ovary/*metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Menarche
OT  - Menopause
OT  - Neuroendocrine
OT  - Reproduction
OT  - Type 2 diabetes mellitus
EDAT- 2020/07/03 06:00
MHDA- 2021/06/05 06:00
CRDT- 2020/07/03 06:00
PHST- 2020/01/02 00:00 [received]
PHST- 2020/06/21 00:00 [accepted]
PHST- 2020/07/03 06:00 [pubmed]
PHST- 2021/06/05 06:00 [medline]
PHST- 2020/07/03 06:00 [entrez]
AID - 10.1007/s42000-020-00225-7 [pii]
AID - 10.1007/s42000-020-00225-7 [doi]
PST - ppublish
SO  - Hormones (Athens). 2020 Sep;19(3):291-300. doi: 10.1007/s42000-020-00225-7. Epub 
      2020 Jul 2.