PMID- 32615470
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 129
DP  - 2020 Oct
TI  - Psychotic depression in hospitalized patients: Longitudinal outcomes of psychotic 
      vs. nonpsychotic depression among inpatients.
PG  - 73-79
LID - S0022-3956(20)30280-6 [pii]
LID - 10.1016/j.jpsychires.2020.06.002 [doi]
AB  - Even though psychotic depression is related to worse outcomes than nonpsychotic 
      depression, there is increasing evidence that this greater severity is not solely 
      explained by the depressive symptoms. We evaluated the socio-demographic and 
      clinical characteristics, as well as the differences in clinical outcomes of 
      psychiatric hospitalization between psychotic and non-psychotic depression. 
      Two-hundred-eighty-eight depressive inpatients were assessed within 72 h after 
      hospitalization and 24 h before discharge. We compared scores of Hamilton 
      Depression Rating Scale 17-items (HDRS-17), Clinical Global Impression (CGI), 
      Brief Psychiatric Rating Scale (BPRS), and Global Assessment of Functioning (GAF) 
      between psychotic and nonpsychotic patients. Instruments were compared both 
      cross-sectionally - on admission and discharge - and longitudinally. Longitudinal 
      outcomes were corrected for potential confounders (sex, age, age at disease 
      onset, years of study, previous history of mania/hypomania, electroconvulsive 
      therapy in current hospitalization, history of attempted suicide, number of 
      suicide attempts, and previous hospitalizations). One-hundred-thirty-one 
      depressive inpatients (45.4%) presented psychotic features. Both groups showed 
      similar HDRS-17 scores at admission and discharge. However, psychotic patients 
      had worse scores on BPRS, CGI, and GAF at both timepoints. Both groups had 
      similar improvement on HDRS-17 (P = 0.75), CGI (P = 0.5), and GAF (P = 0.84), but 
      psychotic patients had greater improvement on BPRS (P < 0.001). Psychotic 
      inpatients showed worse clinical and functional parameters. Nonetheless, the 
      groups did not differ in depressive symptom severity. These findings reinforce 
      the hypothesis that depressive episode with psychotic features is a more severe 
      form of the disease irrespective of intensity of affective symptomatology.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Costa, Felipe Bauer Pinto da
AU  - Costa FBPD
AD  - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Innovations 
      and Interventions for Quality of Life Research Group, Brazil. Electronic address: 
      fbpcosta@gmail.com.
FAU - Trachtenberg, Eduardo
AU  - Trachtenberg E
AD  - Sao Pedro Psychiatric Hospital, Porto Alegre, RS, Brazil; Mario Martins 
      University Foundation, Department of Psychopharmacology, Porto Alegre, RS, 
      Brazil.
FAU - Boni, Aline
AU  - Boni A
AD  - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Hospital de 
      Clinicas de Porto Alegre, Porto Alegre, RS, Brazil.
FAU - Primo de Carvalho Alves, Lucas
AU  - Primo de Carvalho Alves L
AD  - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Hospital de 
      Clinicas de Porto Alegre, Porto Alegre, RS, Brazil; Innovations and Interventions 
      for Quality of Life Research Group, Brazil; Clinical Research Center of Hospital 
      de Clinicas de Porto Alegre, Brazil; Experimental Research Center of Hospital de 
      Clinicas de Porto Alegre, Brazil.
FAU - Magalhaes, Pedro Vieira da Silva
AU  - Magalhaes PVDS
AD  - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Hospital de 
      Clinicas de Porto Alegre, Porto Alegre, RS, Brazil; National Institute for 
      Translational Medicine, Porto Alegre, RS, Brazil; Clinical Research Center of 
      Hospital de Clinicas de Porto Alegre, Brazil; Experimental Research Center of 
      Hospital de Clinicas de Porto Alegre, Brazil.
FAU - Rocha, Neusa Sica
AU  - Rocha NS
AD  - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Hospital de 
      Clinicas de Porto Alegre, Porto Alegre, RS, Brazil; Innovations and Interventions 
      for Quality of Life Research Group, Brazil; Clinical Research Center of Hospital 
      de Clinicas de Porto Alegre, Brazil; Experimental Research Center of Hospital de 
      Clinicas de Porto Alegre, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200602
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - *Bipolar Disorder
MH  - Depression/epidemiology
MH  - Humans
MH  - Inpatients
MH  - Psychiatric Status Rating Scales
MH  - *Psychotic Disorders/epidemiology/therapy
EDAT- 2020/07/03 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/07/03 06:00
PHST- 2020/03/14 00:00 [received]
PHST- 2020/05/25 00:00 [revised]
PHST- 2020/06/01 00:00 [accepted]
PHST- 2020/07/03 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/07/03 06:00 [entrez]
AID - S0022-3956(20)30280-6 [pii]
AID - 10.1016/j.jpsychires.2020.06.002 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2020 Oct;129:73-79. doi: 10.1016/j.jpsychires.2020.06.002. Epub 
      2020 Jun 2.