PMID- 32615710
OWN - NLM
STAT- MEDLINE
DCOM- 20210611
LR  - 20210611
IS  - 2093-5978 (Electronic)
IS  - 2093-596X (Print)
IS  - 2093-596X (Linking)
VI  - 35
IP  - 2
DP  - 2020 Jun
TI  - Recent Updates on Vascular Complications in Patients with Type 2 Diabetes 
      Mellitus.
PG  - 260-271
LID - 10.3803/EnM.2020.35.2.260 [doi]
AB  - It is well known that patients with type 2 diabetes mellitus (T2DM) are at an 
      increased risk of morbidity and mortality from atherosclerotic cardiovascular 
      (CV) complications. Previously, the concept that diabetes mellitus (DM) is a 
      "coronary artery disease (CAD) risk equivalent" was widely accepted, implying 
      that all DM patients should receive intensive management. However, considerable 
      evidence exist for wide heterogeneity in the risk of CV events among T2DM 
      patients and the concept of a "CAD risk equivalent" has changed. Recent 
      guidelines recommend further CV risk stratification in T2DM patients, with 
      treatment tailored to the risk level. Although imaging modalities for 
      atherosclerotic cardiovascular disease (ASCVD) have been used to improve risk 
      prediction, there is currently no evidence that imaging-oriented therapy improves 
      clinical outcomes. Therefore, controversy remains whether we should screen for 
      CVD in asymptomatic T2DM. The coexistence of T2DM and heart failure (HF) is 
      common. Based on recent CV outcome trials, sodium glucose cotransporter-2 
      inhibitors and glucagon like peptide-1 receptor agonists are recommended who have 
      established ASCVD, indicators of high risk, or HF because of their demonstrated 
      benefits for CVD. These circumstances have led to an increasing emphasis on ASCVD 
      and HF in T2DM patients. In this review, we examine the literature published 
      within the last 5 years on the risk assessment of CVD in asymptomatic T2DM 
      patients. In particular, we review recent guidelines regarding screening for CVD 
      and research focusing on the role of coronary artery calcium, coronary computed 
      tomography angiography, and carotid intima-media thickness in asymptomatic T2DM 
      patients.
FAU - Jung, Chan-Hee
AU  - Jung CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of 
      Medicine, Bucheon, Korea.
FAU - Mok, Ji-Oh
AU  - Mok JO
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of 
      Medicine, Bucheon, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200624
PL  - Korea (South)
TA  - Endocrinol Metab (Seoul)
JT  - Endocrinology and metabolism (Seoul, Korea)
JID - 101554139
SB  - IM
MH  - Cardiovascular Diseases/*etiology/pathology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*etiology/pathology
MH  - Humans
MH  - Risk Assessment/*methods
PMC - PMC7386121
OTO - NOTNLM
OT  - Calcium
OT  - Carotid intima-media thickness
OT  - Coronary vessels
OT  - Diabetes mellitus, type 2
OT  - Risk assessment
OT  - Atherosclerosis
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2020/07/04 06:00
MHDA- 2021/06/12 06:00
PMCR- 2020/06/01
CRDT- 2020/07/04 06:00
PHST- 2020/03/31 00:00 [received]
PHST- 2020/06/05 00:00 [accepted]
PHST- 2020/07/04 06:00 [entrez]
PHST- 2020/07/04 06:00 [pubmed]
PHST- 2021/06/12 06:00 [medline]
PHST- 2020/06/01 00:00 [pmc-release]
AID - EnM.2020.35.2.260 [pii]
AID - enm-2020-35-2-260 [pii]
AID - 10.3803/EnM.2020.35.2.260 [doi]
PST - ppublish
SO  - Endocrinol Metab (Seoul). 2020 Jun;35(2):260-271. doi: 10.3803/EnM.2020.35.2.260. 
      Epub 2020 Jun 24.