PMID- 32617004
OWN - NLM
STAT- MEDLINE
DCOM- 20200825
LR  - 20240329
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 15
DP  - 2020
TI  - Smart Hydrogels - Synthetic Stimuli-Responsive Antitumor Drug Release Systems.
PG  - 4541-4572
LID - 10.2147/IJN.S248987 [doi]
AB  - Among modern drug formulations, stimuli-responsive hydrogels also called "smart 
      hydrogels" deserve a special attention. The basic feature of this system is the 
      ability to change their mechanical properties, swelling ability, hydrophilicity, 
      bioactive molecules permeability, etc., influenced by various stimuli, such as 
      temperature, pH, electromagnetic radiation, magnetic field and biological 
      factors. Therefore, stimuli-responsive matrices can be potentially used in tissue 
      engineering, cell cultures and technology of innovative drug delivery systems 
      (DDSs), releasing the active substances under the control of internal or external 
      stimuli. Moreover, smart hydrogels can be used as injectable DDSs, due to gel-sol 
      transition connected with in situ cross-linking process. Innovative smart 
      hydrogel DDSs can be utilized as matrices for targeted therapy, which enhances 
      the effectiveness of tumor chemotherapy and subsequently limits systemic 
      toxicity. External stimulus sensitivity allows remote control over the drug 
      release profile and gel formation. On the other hand, internal factors provide 
      drg accumulation in tumor tissue and reduce the concentration of active drug form 
      in healthy tissue. In this report, we summarise the basic knowledge and chemical 
      strategies for the synthetic smart hydrogel DDSs applied in antitumor therapy.
CI  - (c) 2020 Kasinski et al.
FAU - Kasinski, Adam
AU  - Kasinski A
AUID- ORCID: 0000-0003-0187-9638
AD  - Department of Biomaterials Chemistry, Chair of Analytical Chemistry and 
      Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, 
      Poland.
FAU - Zielinska-Pisklak, Monika
AU  - Zielinska-Pisklak M
AUID- ORCID: 0000-0002-4457-6381
AD  - Department of Biomaterials Chemistry, Chair of Analytical Chemistry and 
      Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, 
      Poland.
FAU - Oledzka, Ewa
AU  - Oledzka E
AUID- ORCID: 0000-0003-0660-3315
AD  - Department of Biomaterials Chemistry, Chair of Analytical Chemistry and 
      Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, 
      Poland.
FAU - Sobczak, Marcin
AU  - Sobczak M
AUID- ORCID: 0000-0002-7362-8881
AD  - Department of Biomaterials Chemistry, Chair of Analytical Chemistry and 
      Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, 
      Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200625
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (Hydrogels)
RN  - 0 (Synthetic Drugs)
SB  - IM
MH  - Animals
MH  - Drug Compounding
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Electromagnetic Fields
MH  - Humans
MH  - Hydrogels/administration & dosage/*chemistry/*pharmacokinetics
MH  - Hydrogen-Ion Concentration
MH  - Synthetic Drugs/pharmacokinetics
MH  - Temperature
MH  - Tissue Engineering
PMC - PMC7326401
OTO - NOTNLM
OT  - anticancer drug delivery systems
OT  - controlled release
OT  - drug delivery systems
OT  - smart hydrogels
OT  - stimuli-responsive hydrogels
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/07/04 06:00
MHDA- 2020/08/26 06:00
PMCR- 2020/06/25
CRDT- 2020/07/04 06:00
PHST- 2020/02/09 00:00 [received]
PHST- 2020/03/28 00:00 [accepted]
PHST- 2020/07/04 06:00 [entrez]
PHST- 2020/07/04 06:00 [pubmed]
PHST- 2020/08/26 06:00 [medline]
PHST- 2020/06/25 00:00 [pmc-release]
AID - 248987 [pii]
AID - 10.2147/IJN.S248987 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2020 Jun 25;15:4541-4572. doi: 10.2147/IJN.S248987. 
      eCollection 2020.