PMID- 32617012
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 13
DP  - 2020
TI  - Effects of Breastfeeding and Formula Feeding on the Expression Level of FTO, 
      CPT1A and PPAR-alpha Genes in Healthy Infants.
PG  - 2227-2237
LID - 10.2147/DMSO.S252122 [doi]
AB  - PURPOSE: The study aimed to investigate the effect of breastfeeding, formula 
      feeding and mix feeding (breastfed plus formula-fed) on the expression level of 
      obesity-predisposing genes including fat mass and obesity-associated (FTO), 
      carnitine palmitoyltransferase 1A (CPT1A), and peroxisome proliferator-activated 
      receptor-alpha (PPAR-alpha) in 5- to 6-month-old infants. PATIENTS AND METHODS: A total 
      of 150 infants participated in this case-control study. All subjects were healthy 
      infants aged 5-6 months that divided into 3 groups: breastfed, formula-fed, and 
      mix-fed. The expression level of FTO, CPT1A, and PPAR-alpha genes in peripheral blood 
      mononuclear cells (PBMC) was evaluated in each group using reverse 
      transcription-polymerase chain reaction (RT-PCR) method. RESULTS: Our findings 
      showed that the current weight, height, and head circumference of infants in the 
      formula feeding and mix feeding groups were significantly higher than those in 
      the exclusive breastfeeding group. The expression level of FTO and CPT1A genes in 
      formula-fed and mix-fed infants was significantly higher (p<0.001) than that in 
      breastfed infants, while the expression level of PPAR-alpha gene was significantly 
      lower (p<0.05). CONCLUSION: Breastfeeding showed modulatory effects on the 
      expression level of obesity-predisposing genes and can protect against obesity 
      and subsequent non-communicable diseases. However, more investigations are 
      required to explain the epigenetic effects of breast milk.
CI  - (c) 2020 Cheshmeh et al.
FAU - Cheshmeh, Sahar
AU  - Cheshmeh S
AUID- ORCID: 0000-0002-0758-7049
AD  - Department of Nutritional Sciences, School of Nutritional Sciences and Food 
      Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
AD  - Student Research Committee, School of Nutritional Sciences and Food Technology, 
      Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Nachvak, Seyed Mostafa
AU  - Nachvak SM
AD  - Department of Nutritional Sciences, School of Nutritional Sciences and Food 
      Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Rezvani, Nayebali
AU  - Rezvani N
AD  - Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Saber, Amir
AU  - Saber A
AUID- ORCID: 0000-0002-9886-0054
AD  - Department of Nutritional Sciences, School of Nutritional Sciences and Food 
      Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
LA  - eng
PT  - Journal Article
DEP - 20200626
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7326192
OTO - NOTNLM
OT  - CPT1A
OT  - FTO
OT  - PPAR-alpha
OT  - breastfeeding
OT  - formula feeding
OT  - infants
OT  - obesity
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/07/04 06:00
MHDA- 2020/07/04 06:01
PMCR- 2020/06/26
CRDT- 2020/07/04 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/06/12 00:00 [accepted]
PHST- 2020/07/04 06:00 [entrez]
PHST- 2020/07/04 06:00 [pubmed]
PHST- 2020/07/04 06:01 [medline]
PHST- 2020/06/26 00:00 [pmc-release]
AID - 252122 [pii]
AID - 10.2147/DMSO.S252122 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2020 Jun 26;13:2227-2237. doi: 10.2147/DMSO.S252122. 
      eCollection 2020.