PMID- 32617486
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2514-2119 (Electronic)
IS  - 2514-2119 (Linking)
VI  - 4
IP  - 3
DP  - 2020 Jun
TI  - Mitral valve bio-prosthesis and annuloplasty thrombosis during extracorporeal 
      membrane oxygenation: case series.
PG  - 1-6
LID - 10.1093/ehjcr/ytaa085 [doi]
AB  - BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a 
      well-recognized form of haemodynamic support for patients with refractory 
      cardiogenic shock, who are unable to be weaned off cardiopulmonary bypass. 
      Thrombosis or bleeding from cannula sites or surgical wounds are the leading 
      cause of morbidity and mortality in these patients, and presents a delicate 
      balance of anticoagulation during management of patients undergoing circulatory 
      support. CASE SUMMARY: In this case series, we discuss three cases of patients 
      undergoing mitral valve replacements or repair with thrombosis of their new 
      bio-prosthesis in the immediate post-operative setting. All three patients were 
      supported with VA-ECMO post-operatively, and thrombosis occurred despite 
      anticoagulation. DISCUSSION: During extracorporeal membrane oxygenation, the 
      reduced flow throughout the heart increases the risk of intra-cardiac thrombosis. 
      This is of particular importance in the context of mitral valve replacements and 
      repairs, where the bio-prosthesis is an additional risk factor for thrombosis. 
      Our cases demonstrate the morbidity and mortality of such complications, with the 
      likely aetiology being low transvalvular flow in a newly inserted valve combined 
      with the pro-thrombotic state created by the VA-ECMO circuit.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Challa, Abhinay
AU  - Challa A
AUID- ORCID: 0000-0003-4401-7691
AD  - Department of Cardiology, The Prince Charles Hospital, Chermside, 4032 Brisbane, 
      Australia.
AD  - Bond University, Robina, 4226 Gold Coast, Australia.
FAU - Latona, Jilani
AU  - Latona J
AUID- ORCID: 0000-0002-1344-495X
AD  - Department of Cardiology, The Prince Charles Hospital, Chermside, 4032 Brisbane, 
      Australia.
FAU - Fraser, John
AU  - Fraser J
AD  - University of Queensland, St Lucia, 4072 Brisbane, Australia.
AD  - Critical Care Research Group, The Prince Charles Hospital, Chermside, 4032 
      Brisbane, Australia.
FAU - Spanevello, Michelle
AU  - Spanevello M
AUID- ORCID: 0000-0003-1498-7822
AD  - University of Queensland, St Lucia, 4072 Brisbane, Australia.
AD  - Department of Haematology, Cancer Care Services, Royal Brisbane and Women's 
      Hospital, Herston, 4029 Brisbane, Australia.
FAU - Scalia, Gregory
AU  - Scalia G
AD  - Department of Cardiology, The Prince Charles Hospital, Chermside, 4032 Brisbane, 
      Australia.
AD  - University of Queensland, St Lucia, 4072 Brisbane, Australia.
FAU - Burstow, Darryl
AU  - Burstow D
AUID- ORCID: 0000-0001-6951-6118
AD  - Department of Cardiology, The Prince Charles Hospital, Chermside, 4032 Brisbane, 
      Australia.
AD  - University of Queensland, St Lucia, 4072 Brisbane, Australia.
FAU - Platts, David
AU  - Platts D
AUID- ORCID: 0000-0002-3466-1283
AD  - Department of Cardiology, The Prince Charles Hospital, Chermside, 4032 Brisbane, 
      Australia.
AD  - University of Queensland, St Lucia, 4072 Brisbane, Australia.
AD  - Critical Care Research Group, The Prince Charles Hospital, Chermside, 4032 
      Brisbane, Australia.
LA  - eng
PT  - Case Reports
DEP - 20200424
PL  - England
TA  - Eur Heart J Case Rep
JT  - European heart journal. Case reports
JID - 101730741
PMC - PMC7319831
OTO - NOTNLM
OT  - Case series
OT  - Extracorporeal membrane oxygenation
OT  - Mitral valve
OT  - Thrombosis
OT  - VA-ECMO
EDAT- 2020/07/04 06:00
MHDA- 2020/07/04 06:01
PMCR- 2020/04/24
CRDT- 2020/07/04 06:00
PHST- 2019/07/20 00:00 [received]
PHST- 2019/08/29 00:00 [revised]
PHST- 2020/03/23 00:00 [accepted]
PHST- 2020/07/04 06:00 [entrez]
PHST- 2020/07/04 06:00 [pubmed]
PHST- 2020/07/04 06:01 [medline]
PHST- 2020/04/24 00:00 [pmc-release]
AID - ytaa085 [pii]
AID - 10.1093/ehjcr/ytaa085 [doi]
PST - epublish
SO  - Eur Heart J Case Rep. 2020 Apr 24;4(3):1-6. doi: 10.1093/ehjcr/ytaa085. 
      eCollection 2020 Jun.