PMID- 32619904
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20231019
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 64
DP  - 2020 Jun
TI  - Polymorphisms of HLA-B: influences on assembly and immunity.
PG  - 137-145
LID - S0952-7915(20)30061-3 [pii]
LID - 10.1016/j.coi.2020.05.008 [doi]
AB  - The major histocompatibility class I (MHC-I) complex functions in innate and 
      adaptive immunity, mediating surveillance of the subcellular environment. In 
      humans, MHC-I heavy chains are encoded by three genes: the human leukocyte 
      antigen (HLA)-A, HLA-B, and HLA-C. These genes are highly polymorphic, which 
      results in the expression, typically, of six different HLA class I (HLA-I) 
      proteins on the cell surface, and the presentation of diverse peptide antigens to 
      CD8(+) T cells for broad surveillance against many pathogenic conditions. Recent 
      studies of HLA-B allotypes show that the polymorphisms, not surprisingly, also 
      significantly impact protein folding and assembly pathways. The use of 
      non-canonical assembly routes and the generation of non-canonical HLA-B 
      conformers has consequences for immune receptor interactions and disease 
      therapies.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Olson, Eli
AU  - Olson E
AD  - Graduate Program in Immunology, Michigan Medicine, University of Michigan, Ann 
      Arbor, MI 48109, USA.
FAU - Geng, Jie
AU  - Geng J
AD  - Department of Microbiology and Immunology, Michigan Medicine, University of 
      Michigan, Ann Arbor, MI 48109, USA.
FAU - Raghavan, Malini
AU  - Raghavan M
AD  - Department of Microbiology and Immunology, Michigan Medicine, University of 
      Michigan, Ann Arbor, MI 48109, USA. Electronic address: malinir@umich.edu.
LA  - eng
GR  - T32 GM145304/GM/NIGMS NIH HHS/United States
GR  - R01 AI123957/AI/NIAID NIH HHS/United States
GR  - T32 AI007413/AI/NIAID NIH HHS/United States
GR  - T32 GM008353/GM/NIGMS NIH HHS/United States
GR  - R01 AI044115/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200630
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adaptive Immunity
MH  - *CD8-Positive T-Lymphocytes
MH  - *HLA-B Antigens/genetics
MH  - Histocompatibility Antigens Class I
MH  - Humans
MH  - Polymorphism, Genetic
PMC - PMC7772265
MID - NIHMS1599843
COIS- Competing financial interests The authors declare no competing financial 
      interests.
EDAT- 2020/07/04 06:00
MHDA- 2022/04/05 06:00
PMCR- 2021/11/12
CRDT- 2020/07/04 06:00
PHST- 2019/10/15 00:00 [received]
PHST- 2020/05/22 00:00 [accepted]
PHST- 2020/07/04 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2020/07/04 06:00 [entrez]
PHST- 2021/11/12 00:00 [pmc-release]
AID - S0952-7915(20)30061-3 [pii]
AID - 10.1016/j.coi.2020.05.008 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2020 Jun;64:137-145. doi: 10.1016/j.coi.2020.05.008. Epub 2020 
      Jun 30.