PMID- 32622964
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20220531
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 510
DP  - 2020 Nov
TI  - A single-center observational study on the expression of circulating 
      interleukin-20 levels and predicting outcomes in human chronic heart failure: A 
      2-year follow-up cohort study: Higher IL-20 levels suggest poorer outcomes in CHF 
      patients.
PG  - 5-10
LID - S0009-8981(20)30312-0 [pii]
LID - 10.1016/j.cca.2020.06.048 [doi]
AB  - BACKGROUND: Interleukin-20 (IL-20) is closely related to cardiovascular diseases 
      such as atherosclerosis. The relevance of IL-20 expression in human chronic heart 
      failure (CHF) remains unknown. Thus, we investigated the level of circulating 
      IL-20 in CHF patients and observed its correlation with CHF outcomes. METHODS: A 
      cohort study was performed with CHF patients. Blood samples of 180 CHF patients 
      and 167 control subjects were collected, and the plasma IL-20 level of each 
      patient was determined. In addition, the endpoints of cardiovascular events among 
      the CHF patients were evaluated prospectively. The maximum follow-up time of 
      these CHF patients was 24 months, and the median follow-up time was 21 months. 
      RESULTS: IL-20 levels were high in CHF patients and gradually increased in the 
      New York Heart Association (NYHA) functional class II, the NYHA III and the NYHA 
      IV groups. According to the low, middle and high tertiles of IL-20 levels, the 
      CHF patients were respectively divided into groups 1, groups 2, and groups 3. 
      Multivariate Cox hazard analysis showed that the group 3 exhibited significantly 
      higher cardiac event morbidity than the other two groups after adjustment for 
      confounding factors. The CHF patients were also divided into two groups according 
      to plasma IL-20 levels, and higher rates of cardiovascular events were observed 
      in the group with higher IL-20 levels. CONCLUSIONS: Circulating IL-20 levels are 
      significantly elevated in CHF patients, and higher IL-20 levels suggest poorer 
      outcomes in CHF patients.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Zhao, Yingying
AU  - Zhao Y
AD  - Xishui County People's Hospital Affiliated to Hubei University of Science and 
      Technology, Hubei 530021, China.
FAU - Yang, Zicong
AU  - Yang Z
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning 530021, China.
FAU - Fang, Cao
AU  - Fang C
AD  - Xishui County People's Hospital Affiliated to Hubei University of Science and 
      Technology, Hubei 530021, China.
FAU - Xiao, Dan
AU  - Xiao D
AD  - Xishui County People's Hospital Affiliated to Hubei University of Science and 
      Technology, Hubei 530021, China.
FAU - Shi, Ying
AU  - Shi Y
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning 530021, China.
FAU - Lin, Yingzhong
AU  - Lin Y
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning 530021, China. Electronic address: yingzhonglin@126.com.
FAU - Zhai, Qun
AU  - Zhai Q
AD  - Xishui County People's Hospital Affiliated to Hubei University of Science and 
      Technology, Hubei 530021, China. Electronic address: zq13636051119@126.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200703
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Interleukins)
RN  - U91R7IMG8U (interleukin 20)
SB  - IM
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Follow-Up Studies
MH  - *Heart Failure
MH  - Humans
MH  - *Interleukins
MH  - New York
MH  - Prognosis
OTO - NOTNLM
OT  - Cardiovascular events
OT  - Chronic heart failure
OT  - Interleukin-20
OT  - Prognosis
EDAT- 2020/07/06 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/07/06 06:00
PHST- 2020/05/29 00:00 [received]
PHST- 2020/06/30 00:00 [revised]
PHST- 2020/06/30 00:00 [accepted]
PHST- 2020/07/06 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/07/06 06:00 [entrez]
AID - S0009-8981(20)30312-0 [pii]
AID - 10.1016/j.cca.2020.06.048 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2020 Nov;510:5-10. doi: 10.1016/j.cca.2020.06.048. Epub 2020 Jul 
      3.