PMID- 32622971
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 442
DP  - 2020 Sep
TI  - Maternal chlormequat chloride exposure disrupts embryonic growth and produces 
      postnatal adverse effects.
PG  - 152534
LID - S0300-483X(20)30173-6 [pii]
LID - 10.1016/j.tox.2020.152534 [doi]
AB  - We showed previously that chlormequat chloride, a widely used plant growth 
      regulator, could affect embryonic growth and growth hormone (GH)-insulin-like 
      growth factor 1 (IGF-1) axis of rats. However, the potential effects of low dose 
      chlormequat chloride exposure during pregnancy on embryonic and postnatal growth 
      and development remain unclear. To further assess the risk of chlormequat 
      chloride to human embryonic growth and postnatal health, we exposed maternal rats 
      orally to the chemical during pregnancy at 5 mg/kg bw, a dose corresponding to 
      the human acceptable daily intake (ADI) level set by World Health Organization 
      (WHO), and determined the effects of chlormequat on embryo growth and postnatal 
      health. We found that chlormequat chloride increased embryonic growth parameters, 
      GH, and GH-releasing hormone (GHRH) levels, but did not affect somatostatin and 
      IGF-1 on gestational day (GD) 11. In the pups of postnatal day (PD) 7, we 
      observed increased head length, decreased body fat percentage, hypoglycemia, 
      hyperlipidemia and hyperproteinemia. In conclusion, maternal exposure to 
      chlormequat chloride during pregnancy disrupts the embryonic growth probably 
      through its effects on growth regulators and even has adverse effects on 
      postnatal health.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Xiagedeer, Bayindala
AU  - Xiagedeer B
AD  - Department of Toxicology, School of Public Health, Peking University, Beijing Key 
      Laboratory of Toxicological Research and Risk Assessment for Food Safety, 
      Beijing, 100191, PR China.
FAU - Hou, Xiaohong
AU  - Hou X
AD  - Department of Toxicology, School of Public Health, Peking University, Beijing Key 
      Laboratory of Toxicological Research and Risk Assessment for Food Safety, 
      Beijing, 100191, PR China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Department of Toxicology, School of Public Health, Peking University, Beijing Key 
      Laboratory of Toxicological Research and Risk Assessment for Food Safety, 
      Beijing, 100191, PR China.
FAU - Hu, Hong
AU  - Hu H
AD  - Department of Toxicology, School of Public Health, Peking University, Beijing Key 
      Laboratory of Toxicological Research and Risk Assessment for Food Safety, 
      Beijing, 100191, PR China.
FAU - Kang, Chenping
AU  - Kang C
AD  - Department of Toxicology, School of Public Health, Peking University, Beijing Key 
      Laboratory of Toxicological Research and Risk Assessment for Food Safety, 
      Beijing, 100191, PR China.
FAU - Xiao, Qianqian
AU  - Xiao Q
AD  - Department of Toxicology, School of Public Health, Peking University, Beijing Key 
      Laboratory of Toxicological Research and Risk Assessment for Food Safety, 
      Beijing, 100191, PR China.
FAU - Hao, Weidong
AU  - Hao W
AD  - Department of Toxicology, School of Public Health, Peking University, Beijing Key 
      Laboratory of Toxicological Research and Risk Assessment for Food Safety, 
      Beijing, 100191, PR China. Electronic address: whao@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200702
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Plant Growth Regulators)
RN  - 51110-01-1 (Somatostatin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 8SUZ1123XX (Chlormequat)
RN  - 9002-72-6 (Growth Hormone)
RN  - 9034-39-3 (Growth Hormone-Releasing Hormone)
SB  - IM
MH  - Abnormalities, Drug-Induced/*pathology
MH  - Animals
MH  - Animals, Newborn
MH  - Body Composition/drug effects
MH  - Bone Density/drug effects
MH  - Chlormequat/*toxicity
MH  - Embryonic Development/*drug effects
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Growth Hormone/biosynthesis
MH  - Growth Hormone-Releasing Hormone/biosynthesis
MH  - Insulin-Like Growth Factor I/biosynthesis
MH  - Male
MH  - Maternal Exposure
MH  - Plant Growth Regulators/toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Somatostatin/biosynthesis
OTO - NOTNLM
OT  - Chlormequat chloride
OT  - Embryonic growth
OT  - Growth hormone (GH)
OT  - Postnatal health
EDAT- 2020/07/06 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/07/06 06:00
PHST- 2020/02/19 00:00 [received]
PHST- 2020/06/29 00:00 [revised]
PHST- 2020/07/01 00:00 [accepted]
PHST- 2020/07/06 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/07/06 06:00 [entrez]
AID - S0300-483X(20)30173-6 [pii]
AID - 10.1016/j.tox.2020.152534 [doi]
PST - ppublish
SO  - Toxicology. 2020 Sep;442:152534. doi: 10.1016/j.tox.2020.152534. Epub 2020 Jul 2.