PMID- 32623224
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 143
DP  - 2020 Oct
TI  - Impact of environmental exposure to persistent organic pollutants on lung cancer 
      risk.
PG  - 105925
LID - S0160-4120(20)31880-8 [pii]
LID - 10.1016/j.envint.2020.105925 [doi]
AB  - BACKGROUND: Recent studies suggest that high pre-diagnostic serum concentrations 
      of persistent organic pollutants (POPs) might result in the development of 
      cancers in the general population. However, the association between 
      pre-diagnostic serum POP concentrations and lung cancer risk has not been 
      studied. Here, we evaluated associations between low-dose environmental exposure 
      to POPs and risk of lung cancer using pre-diagnostic serum samples in a 
      case-cohort study based on a population-based prospective cohort. METHODS: We 
      conducted a case-cohort study based on the Korean National Cancer Center 
      Community Cohort, from which we included 118 lung cancer cases and 252 controls. 
      Serum concentrations of POPs were measured by high resolution gas 
      chromatography/high-resolution mass spectrometry, and data were analyzed using 
      multivariable Cox proportional-hazards regression models. RESULTS: Risk of lung 
      cancer increased per unit increase in the natural log-transformed concentrations 
      of the sum of chlordane congeners, total PCBs, and all PCBs subgrouped by the 
      number of chlorines or ortho- substituted chlorines on the molecules, except for 
      tri/tetrachlorobiphenyls, in all models. Among individual POP analytes with a 
      detection rate >80%, after Bonferroni adjustment, only trans-nonachlor was 
      associated with lung cancer risk. In categorical models, risk of lung cancer was 
      associated with serum concentration of chlordane (4th vs. 1st quartile, hazard 
      ratio [95% confidence interval], 8.79 [2.77-27.97]). Dose-dependent relationships 
      were also found between risk of lung cancer and serum concentrations of PCBs 
      regardless of their degree of chlorination, substitution pattern, or binding 
      affinity to receptors (total PCBs, P = 0.002; mid-chlorinated PCBs, P = 0.004; 
      high-chlorinated PCBs, P < 0.001; non- and mono-ortho PCBs, P = 0.031; di-ortho 
      PCBs, P = 0.003; PCBs with dioxin-like activity, P = 0.011; non-dioxin-like 
      non-/mono-ortho PCBs, P = 0.060). CONCLUSIONS: Serum concentrations of chlordane 
      and PCBs are associated with risk of lung cancer in the general population, even 
      decades after the ban on their production and use.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Park, Eun Young
AU  - Park EY
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Republic of 
      Korea.
FAU - Park, Eunjung
AU  - Park E
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Republic of 
      Korea.
FAU - Kim, Jinsun
AU  - Kim J
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Republic of 
      Korea.
FAU - Oh, Jin-Kyoung
AU  - Oh JK
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Republic of 
      Korea; Department of Cancer Control and Population Health, National Cancer Center 
      Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do 10408, 
      Republic of Korea.
FAU - Kim, Byungmi
AU  - Kim B
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Republic of 
      Korea.
FAU - Hong, Yun-Chul
AU  - Hong YC
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Institute of Environmental Medicine, Seoul National 
      University Medical Research Center, Seoul, Republic of Korea; Environmental 
      Health Center, Seoul National University College of Medicine, Seoul, Republic of 
      Korea.
FAU - Lim, Min Kyung
AU  - Lim MK
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Republic of 
      Korea; Department of Cancer Control and Population Health, National Cancer Center 
      Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do 10408, 
      Republic of Korea. Electronic address: mickey@ncc.re.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200702
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Cohort Studies
MH  - Environmental Exposure/adverse effects
MH  - *Environmental Pollutants/toxicity
MH  - Humans
MH  - *Lung Neoplasms/chemically induced/epidemiology
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls/toxicity
MH  - Prospective Studies
OTO - NOTNLM
OT  - Chlordane
OT  - Environmental exposure
OT  - Lung cancer
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
EDAT- 2020/07/06 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/07/06 06:00
PHST- 2019/12/17 00:00 [received]
PHST- 2020/06/02 00:00 [revised]
PHST- 2020/06/21 00:00 [accepted]
PHST- 2020/07/06 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/07/06 06:00 [entrez]
AID - S0160-4120(20)31880-8 [pii]
AID - 10.1016/j.envint.2020.105925 [doi]
PST - ppublish
SO  - Environ Int. 2020 Oct;143:105925. doi: 10.1016/j.envint.2020.105925. Epub 2020 
      Jul 2.