PMID- 32623875
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20240331
IS  - 2005-6648 (Electronic)
IS  - 1226-3303 (Print)
IS  - 1226-3303 (Linking)
VI  - 36
IP  - 2
DP  - 2021 Mar
TI  - Mortality prediction of serum neutrophil gelatinase-associated lipocalin in 
      patients requiring continuous renal replacement therapy.
PG  - 392-400
LID - 10.3904/kjim.2019.446 [doi]
AB  - BACKGROUND/AIMS: We investigated whether serum neutrophil gelatinase-associated 
      lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) 
      requiring continuous renal replacement therapy (CRRT). METHODS: This study 
      enrolled 169 patients who underwent serum NGAL testing at CRRT initiation from 
      June 2017 to January 2019. The predictive power of serum NGAL level for 28-day 
      mortality was compared to the Acute Physiology and Chronic Health Evaluation-II 
      (APACHE-II) score and Sequential Organ Failure Assessment (SOFA) score via area 
      under the receiver operating characteristic curve (AuROC) value. RESULTS: There 
      were 55 survivors and 114 non-survivors at 28 days post-CRRT initiation. Median 
      serum NGAL level was significantly higher in the non-survivor group than in the 
      survivor group (743.0 ng/mL vs. 504.0 ng/mL, p = 0.003). The AuROC value of serum 
      NGAL level was 0.640, which was lower than APACHEII score and SOFA score values 
      (0.767 and 0.715, respectively). However, in the low APACHE-II score group (< 
      27.5), AuROC value of serum NGAL was significantly increased (0.698), and it was 
      an independent risk factor for 28 day-mortality (hazard ratio, 2.405; 95% 
      confidence interval, 1.209 to 4.783; p = 0.012). CONCLUSION: In patients with AKI 
      requiring CRRT, serum NGAL levels may be useful for predicting short-term 
      mortality in those with low APACHE-II scores.
FAU - Park, Yohan
AU  - Park Y
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Ban, Tae Hyun
AU  - Ban TH
AD  - Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Hyung Duk
AU  - Kim HD
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Ko, Eun Jeong
AU  - Ko EJ
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Lee, Jongmin
AU  - Lee J
AD  - Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal 
      Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University 
      of Korea, Seoul, Korea.
FAU - Kim, Seok Chan
AU  - Kim SC
AD  - Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal 
      Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University 
      of Korea, Seoul, Korea.
FAU - Park, Cheol Whee
AU  - Park CW
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Yang, Chul Woo
AU  - Yang CW
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Yong-Soo
AU  - Kim YS
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Chung, Byung Ha
AU  - Chung BH
AD  - Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200707
PL  - Korea (South)
TA  - Korean J Intern Med
JT  - The Korean journal of internal medicine
JID - 8712418
RN  - 0 (Biomarkers)
RN  - 0 (Lipocalin-2)
SB  - IM
MH  - *Acute Kidney Injury/diagnosis/therapy
MH  - Biomarkers
MH  - *Continuous Renal Replacement Therapy
MH  - Humans
MH  - Kidney Function Tests
MH  - Lipocalin-2
MH  - Predictive Value of Tests
MH  - Renal Replacement Therapy
PMC - PMC7969065
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Critical illness
OT  - Mortality
OT  - Neutrophil gelatinase-associated lipocalin
OT  - Renal replacement therapy
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2020/07/07 06:00
MHDA- 2021/06/25 06:00
PMCR- 2021/03/01
CRDT- 2020/07/07 06:00
PHST- 2019/12/29 00:00 [received]
PHST- 2020/02/05 00:00 [accepted]
PHST- 2020/07/07 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2020/07/07 06:00 [entrez]
PHST- 2021/03/01 00:00 [pmc-release]
AID - kjim.2019.446 [pii]
AID - kjim-2019-446 [pii]
AID - 10.3904/kjim.2019.446 [doi]
PST - ppublish
SO  - Korean J Intern Med. 2021 Mar;36(2):392-400. doi: 10.3904/kjim.2019.446. Epub 
      2020 Jul 7.