PMID- 32623915
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 2158-0022 (Electronic)
IS  - 2158-0014 (Print)
IS  - 2158-0014 (Linking)
VI  - 10
IP  - 7
DP  - 2020 Sep
TI  - A Longitudinal Study of Changes in Resting-State Functional Magnetic Resonance 
      Imaging Functional Connectivity Networks During Healthy Aging.
PG  - 377-384
LID - 10.1089/brain.2019.0724 [doi]
AB  - Background: Vast increases in life expectancy over the last century have led to 
      shifts in population demographics and the emergence of a largely aged population, 
      globally. This has led to a need to understand neurobiological changes associated 
      with healthy aging. Studies on age-related changes in functional connectivity 
      networks have largely been cross-sectional and focused on the default mode 
      network (DMN). The current study investigated longitudinal changes in functional 
      connectivity in multiple resting-state networks over 4 years of aging in 
      cognitively normal older adults. Methods: Resting-state functional magnetic 
      resonance imaging scans from older adults (n = 16) who maintained "cognitive 
      normal" status over 4 years were retrieved at baseline and follow-up from the 
      Alzheimer's Disease Neuroimaging Initiative database. A seed-based approach was 
      executed in Functional MRI of the Brain Software Library (FSL) to examine 
      significant changes in functional connectivity within the DMN, frontoparietal 
      network (FPN), and salience network (SN) within subjects over time. Results: 
      Results indicated significantly (p < 0.05, corrected) reduced functional 
      connectivity in the FPN and SN, but not in the DMN at year 4 compared with 
      baseline in older adults who were cognitively stable. Conclusions: The current 
      study highlights the importance of a longitudinal approach for understanding 
      changes in functional connectivity. The findings also underscore the need to 
      examine multiple networks within the same participants, given that changes were 
      apparent in the FPN and SN but not in the DMN. Future studies should also examine 
      changes in internetwork connectivity as well as shifts in structural connectivity 
      over time. Impact statement Investigations of age-related changes in functional 
      connectivity have largely been cross-sectional and focused on the default mode 
      network (DMN). The current study examined the DMN as well as the frontoparietal 
      network (FN) and salience network (SN), in a group of healthy aging adults over 
      four years. The results revealed decreased functional connectivity over time, in 
      the FN and SN, but not the DMN. These findings provide insights about the healthy 
      aging brain. They also underscore the need to broaden the scope of functional 
      connectivity analyses beyond the DMN and highlight the use of longitudinal 
      methods.
FAU - Oschmann, Meike
AU  - Oschmann M
AD  - Faculty of Medicine, University of Cologne, Koln, Germany.
AD  - Department of Psychology, University of Victoria, Victoria, British Columbia, 
      Canada.
FAU - Gawryluk, Jodie R
AU  - Gawryluk JR
AD  - Department of Psychology, University of Victoria, Victoria, British Columbia, 
      Canada.
AD  - Institute on Aging and Lifelong Health, University of Victoria, British Columbia, 
      Canada.
AD  - Division of Medical Sciences, University of Victoria, British Columbia, Canada.
LA  - eng
GR  - U01 AG024904/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20200819
PL  - United States
TA  - Brain Connect
JT  - Brain connectivity
JID - 101550313
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/*diagnostic imaging/*growth & development
MH  - Brain Mapping
MH  - Cross-Sectional Studies
MH  - Databases, Factual
MH  - Default Mode Network/diagnostic imaging/growth & development
MH  - Female
MH  - Frontal Lobe/diagnostic imaging/growth & development
MH  - Healthy Aging/*physiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/*diagnostic imaging
MH  - Neural Pathways/*diagnostic imaging
MH  - Neuropsychological Tests
MH  - Parietal Lobe/diagnostic imaging/growth & development
MH  - Rest/*physiology
PMC - PMC7495915
OTO - NOTNLM
OT  - fMRI
OT  - functional connectivity
OT  - healthy aging
OT  - longitudinal
COIS- No competing financial interests exist.
EDAT- 2020/07/07 06:00
MHDA- 2021/09/18 06:00
PMCR- 2021/09/01
CRDT- 2020/07/07 06:00
PHST- 2020/07/07 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/07/07 06:00 [entrez]
PHST- 2021/09/01 00:00 [pmc-release]
AID - 10.1089/brain.2019.0724 [pii]
AID - 10.1089/brain.2019.0724 [doi]
PST - ppublish
SO  - Brain Connect. 2020 Sep;10(7):377-384. doi: 10.1089/brain.2019.0724. Epub 2020 
      Aug 19.