PMID- 32625077
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 12
DP  - 2020
TI  - SRC-1 Knockout Exerts No Effect on Amyloid beta Deposition in APP/PS1 Mice.
PG  - 145
LID - 10.3389/fnagi.2020.00145 [doi]
LID - 145
AB  - Steroid receptor coactivator 1 (SRC-1) is the key coactivator because of its 
      transcriptional activity. Previous studies have shown that SRC-1 is abundant in 
      the hippocampus and has been implicated in cognition. SRC-1 is also related to 
      some major risk factors for Alzheimer's disease (AD), such as a decline in 
      estrogen and aging, however, whether SRC-1 is involved in the pathogenesis of AD 
      remains unclear. In this study, we established SRC-1 knockout in AD mice by cross 
      breeding SRC-1(-/-) mutant mice with APP/PS1 transgenic mice, and investigated 
      the expression of some synaptic proteins, the amyloid beta (Abeta) deposition, and 
      activation of astrocytes and microglia in the hippocampus of APP/PS1xSRC-1(-/-) 
      mice. The results showed that SRC-1 knockout neither affects the Abeta plaque and 
      activation of glia, nor changes the expression of synaptic proteins in AD model 
      mice. The above results suggest that the complete deletion of SRC-1 in the embryo 
      exerts no effect on the pathogenesis of APP/PS1 mice. Nevertheless, this study 
      could not eliminate the possible role of SRC-1 in the development of AD due to 
      the lack of observation of other events in AD such as tau hyperphosphorylation 
      and the limitation of the animal model employed.
CI  - Copyright (c) 2020 Wu, Wang, Li, Zhang, Ntim, Wu, Li, Zhu, Jiang, Yang, Yuan and 
      Li.
FAU - Wu, Qiong
AU  - Wu Q
AD  - Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of 
      Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 
      China.
FAU - Wang, Bin
AU  - Wang B
AD  - Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of 
      Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 
      China.
FAU - Li, Qi-Fa
AU  - Li QF
AD  - Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of 
      Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 
      China.
FAU - Zhang, Xuan
AU  - Zhang X
AD  - National-Local Joint Engineering Research Center for Drug-Research and 
      Development (R and D) of Neurodegenerative Diseases, Dalian Medical University, 
      Dalian, China.
FAU - Ntim, Michael
AU  - Ntim M
AD  - Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of 
      Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 
      China.
FAU - Wu, Xue-Fei
AU  - Wu XF
AD  - Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of 
      Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 
      China.
FAU - Li, Na
AU  - Li N
AD  - National-Local Joint Engineering Research Center for Drug-Research and 
      Development (R and D) of Neurodegenerative Diseases, Dalian Medical University, 
      Dalian, China.
FAU - Zhu, Dan-Dan
AU  - Zhu DD
AD  - Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of 
      Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 
      China.
FAU - Jiang, Rong
AU  - Jiang R
AD  - Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of 
      Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 
      China.
FAU - Yang, Jin-Yi
AU  - Yang JY
AD  - Department of Urology, Affiliated Dalian Friendship Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Yuan, Yu-Hui
AU  - Yuan YH
AD  - Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
FAU - Li, Shao
AU  - Li S
AD  - Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of 
      Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200617
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC7311769
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - amyloid-beta
OT  - glia
OT  - steroid receptor coactivator 1
OT  - synapse
EDAT- 2020/07/07 06:00
MHDA- 2020/07/07 06:01
PMCR- 2020/01/01
CRDT- 2020/07/07 06:00
PHST- 2019/12/14 00:00 [received]
PHST- 2020/04/29 00:00 [accepted]
PHST- 2020/07/07 06:00 [entrez]
PHST- 2020/07/07 06:00 [pubmed]
PHST- 2020/07/07 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2020.00145 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2020 Jun 17;12:145. doi: 10.3389/fnagi.2020.00145. 
      eCollection 2020.