PMID- 32625707
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231113
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 16
IP  - 10
DP  - 2018 Oct
TI  - Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 
      Rev.1): 74 alpha,beta-unsaturated aliphatic aldehydes and precursors from chemical 
      subgroup 1.1.1 of FGE.19.
PG  - e05422
LID - 10.2903/j.efsa.2018.5422 [doi]
LID - e05422
AB  - The Panel on Food Additives and Flavourings of the European Food Safety Authority 
      was requested to evaluate the genotoxic potential of 74 flavouring substances 
      from subgroup 1.1.1 of FGE.19 in the Flavouring Group Evaluation 200 Revision 1 
      (FGE.200 Rev1). In FGE.200, genotoxicity studies were provided for one 
      representative substance, namely hex-2(trans)-enal [FL-no: 05.073], and for other 
      two substances in the same subgroup, namely 2-dodecenal [FL-no: 05.037] and 
      2-nonenal [FL-no: 05.171]. The Panel concluded that the concern still remains 
      with respect to genotoxicity for the substances of this subgroup and requested an 
      in vivo Comet assay performed in duodenum and liver for hex-2(trans)-enal [FL-no: 
      05.073]. For the two other representative substances of subgroup 1.1.1 
      (nona-2(trans),6(cis)-dienal [FL-no: 05.058] and oct-2-enal [FL-no: 05.060]), the 
      Panel requested a combined in vivo Comet assay and micronucleus assay. These data 
      have been provided and are evaluated in the present opinion FGE.200 Rev1. 
      Industry submitted genotoxicity studies on trans-2-octenal [FL-no: 05.190], 
      instead of oct-2-enal [FL-no: 05.060]. Based on the available data, the 
      Panel concluded that the concern for genotoxicity can be ruled out for 
      hex-2(trans)-enal [FL-no: 05.073], trans-2-octenal [FL-no: 05.190] and 
      nona-2(trans),6(cis)-dienal [FL-no: 05.058], therefore all the 74 substances 
      [FL-no: 02.020, 02.049, 02.050, 02.090, 02.112, 02.137, 02.156, 02.192, 02.210, 
      02.231, 05.037, 05.058, 05.060, 05.070, 05.072, 05.073, 05.076, 05.078, 05.102, 
      05.109, 05.111, 05.114, 05.120, 05.144, 05.150, 05.171, 05.172, 05.179, 05.184, 
      05.189, 05.190, 05.191, 05.195, 06.025, 06.031, 06.072, 09.054, 09.097, 09.109, 
      09.119, 09.146, 09.233, 09.244, 09.247, 09.276, 09.277, 09.303, 09.312, 09.385, 
      09.394, 09.395, 09.396, 09.397, 09.398, 09.399, 09.400, 09.410, 09.411, 09.469, 
      09.482, 09.489, 09.492, 09.493, 09.498, 09.678, 09.701, 09.719, 09.741, 09.790, 
      09.841, 09.866, 09.947, 09.948, 13.004] can be evaluated through the Procedure 
      for flavouring substances.
CI  - (c) 2018 European Food Safety Authority. EFSA Journal published by John Wiley and 
      Sons Ltd on behalf of European Food Safety Authority.
CN  - EFSA Panel on Food Additives and Flavourings (FAF)
FAU - Younes, Maged
AU  - Younes M
FAU - Aquilina, Gabriele
AU  - Aquilina G
FAU - Castle, Laurence
AU  - Castle L
FAU - Engel, Karl-Heinz
AU  - Engel KH
FAU - Fowler, Paul
AU  - Fowler P
FAU - Frutos Fernandez, Maria Jose
AU  - Frutos Fernandez MJ
FAU - Furst, Peter
AU  - Furst P
FAU - Gundert-Remy, Ursula
AU  - Gundert-Remy U
FAU - Husoy, Trine
AU  - Husoy T
FAU - Mennes, Wim
AU  - Mennes W
FAU - Moldeus, Peter
AU  - Moldeus P
FAU - Oskarsson, Agneta
AU  - Oskarsson A
FAU - Rainieri, Sandra
AU  - Rainieri S
FAU - Shah, Romina
AU  - Shah R
FAU - Waalkens-Berendsen, Ine
AU  - Waalkens-Berendsen I
FAU - Wolfle, Detlef
AU  - Wolfle D
FAU - Binderup, Mona-Lise
AU  - Binderup ML
FAU - Bolognesi, Claudia
AU  - Bolognesi C
FAU - Marcon, Francesca
AU  - Marcon F
FAU - Marzin, Daniel
AU  - Marzin D
FAU - Mosesso, Pasquale
AU  - Mosesso P
FAU - Carfi, Maria
AU  - Carfi M
FAU - Vianello, Giorgia
AU  - Vianello G
FAU - Gurtler, Rainer
AU  - Gurtler R
LA  - eng
PT  - Journal Article
DEP - 20181019
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC7009627
OTO - NOTNLM
OT  - FGE.19
OT  - FGE.200
OT  - flavouring substances
OT  - safety evaluation
OT  - straight chain
OT  - subgroup 1.1.1
OT  - alpha,beta-unsaturated aldehydes
EDAT- 2018/10/19 00:00
MHDA- 2018/10/19 00:01
PMCR- 2018/10/19
CRDT- 2020/07/07 06:00
PHST- 2020/07/07 06:00 [entrez]
PHST- 2018/10/19 00:00 [pubmed]
PHST- 2018/10/19 00:01 [medline]
PHST- 2018/10/19 00:00 [pmc-release]
AID - EFS25422 [pii]
AID - 10.2903/j.efsa.2018.5422 [doi]
PST - epublish
SO  - EFSA J. 2018 Oct 19;16(10):e05422. doi: 10.2903/j.efsa.2018.5422. eCollection 
      2018 Oct.