PMID- 32625832
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 16
IP  - 3
DP  - 2018 Mar
TI  - Safety and efficacy of Coxiril((R)) (diclazuril) for pheasants.
PG  - e05196
LID - 10.2903/j.efsa.2018.5196 [doi]
LID - e05196
AB  - Following a request from the European Commission, the Panel on Additives and 
      Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a 
      scientific opinion on the safety and efficacy of Coxiril((R)) for pheasants. 
      Coxiril((R)), containing 0.5% diclazuril, is intended for the prevention of 
      coccidiosis in pheasants at a dose range of 1.0-1.2 mg/kg of complete feed. 
      Diclazuril from Coxiril((R)) is considered safe for pheasants at a level of 
      1.2 mg/kg complete feed. The conclusion was made by extrapolating the results of 
      a tolerance study with turkeys for fattening. The FEEDAP Panel considered that 
      the residues in pheasant tissues and eggs would be of the same magnitude as those 
      measured in the physiologically similar major species chickens and turkeys for 
      fattening. The use of diclazuril at a maximum concentration of 1.2 mg/kg complete 
      fed for pheasants would be safe for the consumer, provided that the maximum 
      residue limits (MRLs) established for poultry would not be exceeded. The 
      conclusions on the safety of the additive for the target species and the consumer 
      are made under the provision that Coxiril((R)) is not fed to laying birds. 
      Coxiril((R)) is considered as a non-irritant to eyes and skin. It is not a 
      potential skin sensitiser. User inhalation exposure to Coxiril((R)), as a result of 
      normal handling, is unlikely to cause respiratory or systemic toxicity. The use 
      of diclazuril from Coxiril((R)) in pheasants does not pose a risk to the 
      environment for neutral/alkaline soils (pH >/= 7). A final conclusion on the risk 
      resulting from the use of the additive in acid soil cannot be done due to the 
      high uncertainties related to potential accumulation of diclazuril over time. The 
      FEEDAP Panel concluded that diclazuril from Coxiril((R)) at a minimum dose of 
      1 mg/kg complete feed has the potential to control coccidiosis in pheasants.
CI  - (c) 2018 European Food Safety Authority. EFSA Journal published by John Wiley and 
      Sons Ltd on behalf of European Food Safety Authority.
CN  - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
FAU - Rychen, Guido
AU  - Rychen G
FAU - Aquilina, Gabriele
AU  - Aquilina G
FAU - Azimonti, Giovanna
AU  - Azimonti G
FAU - Bampidis, Vasileios
AU  - Bampidis V
FAU - Bastos, Maria de Lourdes
AU  - Bastos ML
FAU - Bories, Georges
AU  - Bories G
FAU - Chesson, Andrew
AU  - Chesson A
FAU - Cocconcelli, Pier Sandro
AU  - Cocconcelli PS
FAU - Flachowsky, Gerhard
AU  - Flachowsky G
FAU - Kolar, Boris
AU  - Kolar B
FAU - Kouba, Maryline
AU  - Kouba M
FAU - Lopez-Alonso, Marta
AU  - Lopez-Alonso M
FAU - Lopez Puente, Secundino
AU  - Lopez Puente S
FAU - Mantovani, Alberto
AU  - Mantovani A
FAU - Mayo, Baltasar
AU  - Mayo B
FAU - Ramos, Fernando
AU  - Ramos F
FAU - Saarela, Maria
AU  - Saarela M
FAU - Villa, Roberto Edoardo
AU  - Villa RE
FAU - Wallace, Robert John
AU  - Wallace RJ
FAU - Wester, Pieter
AU  - Wester P
FAU - Brantom, Paul
AU  - Brantom P
FAU - Halle, Ingrid
AU  - Halle I
FAU - van Beelen, Patrick
AU  - van Beelen P
FAU - Holczknecht, Orsolya
AU  - Holczknecht O
FAU - Vettori, Maria Vittoria
AU  - Vettori MV
FAU - Gropp, Jurgen
AU  - Gropp J
LA  - eng
PT  - Journal Article
DEP - 20180322
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC7009574
OTO - NOTNLM
OT  - Coxiril(R)
OT  - coccidiostats
OT  - diclazuril
OT  - efficacy
OT  - pheasants
OT  - safety
EDAT- 2018/03/22 00:00
MHDA- 2018/03/22 00:01
PMCR- 2018/03/22
CRDT- 2020/07/07 06:00
PHST- 2020/07/07 06:00 [entrez]
PHST- 2018/03/22 00:00 [pubmed]
PHST- 2018/03/22 00:01 [medline]
PHST- 2018/03/22 00:00 [pmc-release]
AID - EFS25196 [pii]
AID - 10.2903/j.efsa.2018.5196 [doi]
PST - epublish
SO  - EFSA J. 2018 Mar 22;16(3):e05196. doi: 10.2903/j.efsa.2018.5196. eCollection 2018 
      Mar.