PMID- 32626196
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 17
IP  - 12
DP  - 2019 Dec
TI  - Safety and efficacy of Elancoban((R)) G200 (monensin sodium) for chickens for 
      fattening, chickens reared for laying and turkeys.
PG  - e05891
LID - 10.2903/j.efsa.2019.5891 [doi]
LID - e05891
AB  - The feed additive Elancoban((R)) G200, containing the active substance monensin 
      sodium, an ionophore anticoccidial, is intended to control coccidiosis in 
      chickens for fattening, chickens reared for laying and turkeys. The FEEDAP 
      Panel cannot conclude on the safety of the additive for the target species, 
      consumer, user and environment with regard to the safety of the production 
      strain. The following conclusions apply to monensin sodium included in the 
      additive. Based on the available data set, the FEEDAP Panel cannot conclude on 
      the safety of Elancoban((R)) G200 for chickens for fattening. Monensin sodium is 
      safe for turkeys for fattening with a margin of safety of 1.5. Monensin sodium is 
      not genotoxic and not carcinogenic. The pharmacological no observed adverse 
      effect level (NOAEL) of 0.345 mg monensin sodium/kg body weight (bw) per day was 
      identified in dog. The acceptable daily intake (ADI) derived from this NOAEL is 
      0.003 mg monensin sodium/kg bw applying an uncertainty factor of 100. 
      Elancoban((R)) G200 is safe for the consumer. The existing maximum residue limits 
      (MRLs) ensure consumer safety, provided that the withdrawal period of 1 day is 
      respected. Elancoban((R)) G200 is very irritant for the eye, but it is not a skin 
      irritant. Elancoban((R)) G200 should be regarded as a potential skin and 
      respiratory sensitiser. Inhalation exposure is considered a risk to persons 
      handling the additive. Elancoban((R)) G200 does not pose a risk for the terrestrial 
      compartment, the aquatic compartment and the sediment. The bioaccumulation 
      potential of monensin in the environment is low. Monensin sodium from 
      Elancoban((R)) G200 has the potential to effectively control coccidiosis in 
      chickens for fattening and chickens reared for laying. The FEEDAP Panel cannot 
      conclude on the efficacy Elancoban((R)) G200 as a coccidiostat for turkeys for 
      fattening.
CI  - (c) 2019 European Food Safety Authority. EFSA Journal published by John Wiley and 
      Sons Ltd on behalf of European Food Safety Authority.
CN  - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
FAU - Bampidis, Vasileios
AU  - Bampidis V
FAU - Azimonti, Giovanna
AU  - Azimonti G
FAU - Bastos, Maria de Lourdes
AU  - Bastos ML
FAU - Christensen, Henrik
AU  - Christensen H
FAU - Dusemund, Birgit
AU  - Dusemund B
FAU - Kos Durjava, Mojca
AU  - Kos Durjava M
FAU - Lopez-Alonso, Marta
AU  - Lopez-Alonso M
FAU - Lopez Puente, Secundino
AU  - Lopez Puente S
FAU - Marcon, Francesca
AU  - Marcon F
FAU - Mayo, Baltasar
AU  - Mayo B
FAU - Pechova, Alena
AU  - Pechova A
FAU - Petkova, Mariana
AU  - Petkova M
FAU - Ramos, Fernando
AU  - Ramos F
FAU - Sanz, Yolanda
AU  - Sanz Y
FAU - Villa, Roberto Edoardo
AU  - Villa RE
FAU - Woutersen, Ruud
AU  - Woutersen R
FAU - Bories, Georges
AU  - Bories G
FAU - Brantom, Paul
AU  - Brantom P
FAU - Gropp, Jurgen
AU  - Gropp J
FAU - Finizio, Antonio
AU  - Finizio A
FAU - Focks, Andreas
AU  - Focks A
FAU - Teodorovic, Ivana
AU  - Teodorovic I
FAU - Glandorf, Boet
AU  - Glandorf B
FAU - Herman, Lieve
AU  - Herman L
FAU - Prieto Maradona, Miguel
AU  - Prieto Maradona M
FAU - Holczknecht, Orsolya
AU  - Holczknecht O
FAU - Tarres-Call, Jordi
AU  - Tarres-Call J
FAU - Vettori, Maria Vittoria
AU  - Vettori MV
FAU - Kouba, Maryline
AU  - Kouba M
LA  - eng
PT  - Journal Article
DEP - 20191216
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC7008793
OTO - NOTNLM
OT  - chickens for fattening
OT  - chickens reared for laying
OT  - coccidiostats
OT  - monensin sodium
OT  - safety and efficacy
OT  - turkeys
EDAT- 2020/07/07 06:00
MHDA- 2020/07/07 06:01
PMCR- 2019/12/16
CRDT- 2020/07/07 06:00
PHST- 2020/07/07 06:00 [entrez]
PHST- 2020/07/07 06:00 [pubmed]
PHST- 2020/07/07 06:01 [medline]
PHST- 2019/12/16 00:00 [pmc-release]
AID - EFS25891 [pii]
AID - 10.2903/j.efsa.2019.5891 [doi]
PST - epublish
SO  - EFSA J. 2019 Dec 16;17(12):e05891. doi: 10.2903/j.efsa.2019.5891. eCollection 
      2019 Dec.