PMID- 32626408
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240426
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 17
IP  - 8
DP  - 2019 Aug
TI  - Modification of the terms of authorisation regarding the maximum inclusion level 
      of Maxiban((R)) G160 (narasin and nicarbazin) for chickens for fattening.
PG  - e05786
LID - 10.2903/j.efsa.2019.5786 [doi]
LID - e05786
AB  - Following the request from the European Commission, the Panel on Additives and 
      Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a 
      scientific opinion on the proposed modification of the terms of the authorisation 
      regarding the maximum inclusion level of Maxiban((R)) G160. The FEEDAP Panel cannot 
      conclude on the safety of Maxiban((R)) G160 at a dose level of 70 + 70 mg/kg feed 
      for the target species. The use of Maxiban((R)) G160 in diets for chickens for 
      fattening at the maximum proposed dose complies with the maximum residue levels 
      (MRLs) in force of narasin and 4,4'-dinitrocarbanilide (DNC) at 0-day withdrawal 
      except for DNC in kidney which was slightly above the MRL. Compliance with DNC 
      MRLs was seen in all tissues at 1-day withdrawal. Based on the available data, 
      the FEEDAP Panel cannot conclude on the safety of Maxiban((R)) G160 for the 
      environment due to the risk identified for the terrestrial organisms due to DNC. 
      Moreover, the high persistence and hydrophobicity of DNC indicate that there 
      might be a risk for bioaccumulation but the risk for secondary poisoning was not 
      identified. The potential of DNC to accumulate in soil over the years should be 
      investigated by monitoring in a field study. The FEEDAP Panel would not be in the 
      position to conclude on the efficacy of Maxiban((R)) G160 in chickens for fattening 
      based on the data provided for the dose of 40 + 40 mg narasin + nicarbazin/kg 
      feed.
CI  - (c) 2019 European Food Safety Authority. EFSA Journal published by John Wiley and 
      Sons Ltd on behalf of European Food Safety Authority.
CN  - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
FAU - Bampidis, Vasileios
AU  - Bampidis V
FAU - Azimonti, Giovanna
AU  - Azimonti G
FAU - Bastos, Maria de Lourdes
AU  - Bastos ML
FAU - Christensen, Henrik
AU  - Christensen H
FAU - Dusemund, Birgit
AU  - Dusemund B
FAU - Kos Durjava, Mojca
AU  - Kos Durjava M
FAU - Lopez-Alonso, Marta
AU  - Lopez-Alonso M
FAU - Lopez Puente, Secundino
AU  - Lopez Puente S
FAU - Marcon, Francesca
AU  - Marcon F
FAU - Mayo, Baltasar
AU  - Mayo B
FAU - Pechova, Alena
AU  - Pechova A
FAU - Petkova, Mariana
AU  - Petkova M
FAU - Ramos, Fernando
AU  - Ramos F
FAU - Sanz, Yolanda
AU  - Sanz Y
FAU - Villa, Roberto Edoardo
AU  - Villa RE
FAU - Woutersen, Ruud
AU  - Woutersen R
FAU - Bories, Georges
AU  - Bories G
FAU - Brantom, Paul
AU  - Brantom P
FAU - Gropp, Jurgen
AU  - Gropp J
FAU - Finizio, Antonio
AU  - Finizio A
FAU - Focks, Andreas
AU  - Focks A
FAU - Teodorovic, Ivana
AU  - Teodorovic I
FAU - Holczknecht, Orsolya
AU  - Holczknecht O
FAU - Tarres-Call, Jordi
AU  - Tarres-Call J
FAU - Vettori, Maria Vittoria
AU  - Vettori MV
FAU - Kouba, Maryline
AU  - Kouba M
LA  - eng
PT  - Journal Article
DEP - 20190808
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC7009132
OTO - NOTNLM
OT  - Maxiban(R) G160
OT  - chickens for fattening
OT  - maximum inclusion level
OT  - narasin
OT  - nicarbazin
EDAT- 2020/07/07 06:00
MHDA- 2020/07/07 06:01
PMCR- 2019/08/08
CRDT- 2020/07/07 06:00
PHST- 2020/07/07 06:00 [entrez]
PHST- 2020/07/07 06:00 [pubmed]
PHST- 2020/07/07 06:01 [medline]
PHST- 2019/08/08 00:00 [pmc-release]
AID - EFS25786 [pii]
AID - 10.2903/j.efsa.2019.5786 [doi]
PST - epublish
SO  - EFSA J. 2019 Aug 8;17(8):e05786. doi: 10.2903/j.efsa.2019.5786. eCollection 2019 
      Aug.