PMID- 32626602
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2057-3804 (Electronic)
IS  - 2057-3804 (Linking)
VI  - 6
DP  - 2020
TI  - Cardiac MRI utilizing late gadolinium enhancement (LGE) and T1 mapping in the 
      detection of radiation induced heart disease.
PG  - 6
LID - 10.1186/s40959-020-00061-z [doi]
LID - 6
AB  - BACKGROUND AND PURPOSE: Radiotherapy has been associated with late dose-dependent 
      cardiovascular toxicity. In this cross-sectional pilot study, radiation dose 
      distributions were correlated with areas of localized and diffuse myocardial 
      fibrosis as measured by novel cardiac MRI (CMR) sequences including late 
      gadolinium enhancement (LGE) and T1 mapping with the goal to identify early 
      markers of myocardial damage. MATERIALS AND METHODS: Twenty-eight patients with 
      chest tumors including lung, breast, esophagus, and lymphoma underwent CMR per 
      study protocol on average 46.4 months (range 1.7-344.5) after radiotherapy. 
      Patients without pretreatment cardiac history were included if the volume of 
      heart receiving 5 Gy or more was at least 10% (V5Gy >/= 10%). The association of 
      LGE with cardiac dosimetric factors, clinical factors (e.g., tumor type, smoking 
      history, BMI), and T1 values was analyzed. RESULTS: Cardiac maximum (Dmax) and 
      mean dose (Dmean) equivalent to doses delivered in 2 Gy fractions (EQD2) were on 
      average 50.9 Gy (range 6.2-108.0) and 8.2 Gy (range 1.0-35.7), respectively, 
      compared to 60.8 Gy (40.8-108.0) and 6.8 Gy (1.8-21.8) among the 9 patients with 
      LGE. Doses were not different between patients with and without LGE (p = 0.16 and 
      0.56, respectively). The average T1 value of the left ventricle myocardium was 
      1009 ms (range 933-1117). No significant correlation was seen for heart Dmax and 
      Dmean and T1 values (p = 0.14 and 0.58, respectively). In addition, no 
      significant association between clinical factors and the development of LGE was 
      identified. CONCLUSIONS: No relation between cardiac doses, the presence of LGE 
      or T1 values was observed. Further study is needed to determine the benefit of 
      CMR for detecting radiotherapy-related myocardial fibrosis.
CI  - (c) The Author(s) 2020.
FAU - Ricco, Anthony
AU  - Ricco A
AD  - Department of Radiation Oncology, Virginia Commonwealth University Health System, 
      401 College Street, Richmond, VA 23298 USA. GRID: grid.224260.0. ISNI: 0000 0004 
      0458 8737
FAU - Slade, Alexander
AU  - Slade A
AD  - Department of Radiation Oncology, Virginia Commonwealth University Health System, 
      401 College Street, Richmond, VA 23298 USA. GRID: grid.224260.0. ISNI: 0000 0004 
      0458 8737
FAU - Canada, Justin M
AU  - Canada JM
AD  - Department of Cardiology, Virginia Commonwealth University Health System, 
      Richmond, VA USA. GRID: grid.224260.0. ISNI: 0000 0004 0458 8737
AD  - Department of Kinesiology & Health Sciences, Virginia Commonwealth University 
      Health System, Richmond, VA USA. GRID: grid.224260.0. ISNI: 0000 0004 0458 8737
FAU - Grizzard, John
AU  - Grizzard J
AD  - Department of Radiology, Virginia Commonwealth University Health System, 
      Richmond, VA USA. GRID: grid.224260.0. ISNI: 0000 0004 0458 8737
FAU - Dana, Franklin
AU  - Dana F
AD  - Department of Radiology, Virginia Commonwealth University Health System, 
      Richmond, VA USA. GRID: grid.224260.0. ISNI: 0000 0004 0458 8737
FAU - Rezai Gharai, Leila
AU  - Rezai Gharai L
AD  - Department of Radiology, Virginia Commonwealth University Health System, 
      Richmond, VA USA. GRID: grid.224260.0. ISNI: 0000 0004 0458 8737
FAU - Neiderer, Keith
AU  - Neiderer K
AD  - Department of Radiation Oncology, Virginia Commonwealth University Health System, 
      401 College Street, Richmond, VA 23298 USA. GRID: grid.224260.0. ISNI: 0000 0004 
      0458 8737
FAU - Vera, Armando
AU  - Vera A
AD  - Department of Radiation Oncology, Virginia Commonwealth University Health System, 
      401 College Street, Richmond, VA 23298 USA. GRID: grid.224260.0. ISNI: 0000 0004 
      0458 8737
FAU - Abbate, Antonio
AU  - Abbate A
AD  - Department of Cardiology, Virginia Commonwealth University Health System, 
      Richmond, VA USA. GRID: grid.224260.0. ISNI: 0000 0004 0458 8737
FAU - Weiss, Elisabeth
AU  - Weiss E
AD  - Department of Radiation Oncology, Virginia Commonwealth University Health System, 
      401 College Street, Richmond, VA 23298 USA. GRID: grid.224260.0. ISNI: 0000 0004 
      0458 8737
LA  - eng
GR  - UL1 TR002649/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20200701
PL  - England
TA  - Cardiooncology
JT  - Cardio-oncology (London, England)
JID - 101689938
PMC - PMC7329507
OTO - NOTNLM
OT  - Cardiac MRI
OT  - Cardiotoxicity from radiotherapy
OT  - Late gadolinium enhancement
OT  - Radiation induced heart disease
OT  - T1 mapping
COIS- Competing interestsEW receives research funding through NIH and Varian Medical 
      Systems, as well as royalties from UpToDate.
EDAT- 2020/07/07 06:00
MHDA- 2020/07/07 06:01
PMCR- 2020/07/01
CRDT- 2020/07/07 06:00
PHST- 2020/05/03 00:00 [received]
PHST- 2020/06/21 00:00 [accepted]
PHST- 2020/07/07 06:00 [entrez]
PHST- 2020/07/07 06:00 [pubmed]
PHST- 2020/07/07 06:01 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 61 [pii]
AID - 10.1186/s40959-020-00061-z [doi]
PST - epublish
SO  - Cardiooncology. 2020 Jul 1;6:6. doi: 10.1186/s40959-020-00061-z. eCollection 
      2020.