PMID- 32627414
OWN - NLM
STAT- MEDLINE
DCOM- 20200924
LR  - 20200924
IS  - 2366-7478 (Print)
IS  - 2366-7478 (Linking)
VI  - 3
IP  - 5
DP  - 2019 May
TI  - Carbon Nanotubes, Directly Grown on Supporting Surfaces, Improve Neuronal 
      Activity in Hippocampal Neuronal Networks.
PG  - e1800286
LID - 10.1002/adbi.201800286 [doi]
AB  - Carbon nanotube (CNT)-modified surfaces unequivocally demonstrate their 
      biocompatibility and ability to boost the electrical activity of neuronal cells 
      cultured on them. Reasons for this effect are still under debate. However, the 
      intimate contact at the membrane level between these thready nanostructures and 
      cells, in combination with their unique electrical properties, seems to play an 
      important role. The entire existing literature exploiting the effect of CNTs on 
      modulating cellular behavior deals with cell cultures grown on purified 
      multiwalled carbon nanotubes (MWNTs) deposited on a supporting surface via 
      drop-casting or mechanical entrapment. Here, for the first time, it is 
      demonstrated that CNTs directly grown on a supporting silicon surface by a 
      chemical vapor deposition (CVD)-assisted technique have the same effect. It is 
      shown that primary neuronal cells developed above a carpet of CVD CNTs form a 
      healthy and functional network. The resulting neuronal network shows increased 
      electrical activity when compared to a similar network developed on a control 
      glass surface. The low cost and high versatility of the here presented CVD-based 
      synthesis process, together with the possibility to create on supporting 
      substrate patterns of any arbitrary shape of CNTs, open up new opportunities for 
      brain-machine interfaces or neuroprosthetic devices.
CI  - (c) 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Rago, Ilaria
AU  - Rago I
AD  - Department of Physics, University of Trieste, Piazzale Europa 1, 34127, Trieste, 
      Italy.
FAU - Rauti, Rossana
AU  - Rauti R
AD  - Neurobiology Sector, International School for Advanced Studies (SISSA/ISAS), Via 
      Bonomea 265, 34136, Trieste, Italy.
FAU - Bevilacqua, Manuela
AU  - Bevilacqua M
AD  - Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via 
      Giorgieri 1, 34127, Trieste, Italy.
AD  - CNR-ICCOM, Via Madonna del Piano 10, 50019, Sesto Fiorentino, Italy.
AD  - ICCOM-CNR Trieste Research Unit, Via Giorgieri 1, 34127, Trieste, Italy.
FAU - Calaresu, Ivo
AU  - Calaresu I
AD  - Neurobiology Sector, International School for Advanced Studies (SISSA/ISAS), Via 
      Bonomea 265, 34136, Trieste, Italy.
FAU - Pozzato, Alessandro
AU  - Pozzato A
AD  - ThunderNIL srl, Via Foscolo 8, I-35131, Padova, Italy.
AD  - IOM-CNR Area Science Park, Basovizza, S.S. 14, km 163.5, 34149, Trieste, Italy.
FAU - Cibinel, Matteo
AU  - Cibinel M
AD  - Department of Engineering and Architecture, University of Trieste, Via Valerio 
      6/1, 34127, Trieste, Italy.
FAU - Dalmiglio, Matteo
AU  - Dalmiglio M
AD  - Elettra-Sincrotrone Trieste, Area Science Park, S.S. 14, km 163.5, 34149, 
      Trieste, Italy.
FAU - Tavagnacco, Claudio
AU  - Tavagnacco C
AD  - Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via 
      Giorgieri 1, 34127, Trieste, Italy.
FAU - Goldoni, Andrea
AU  - Goldoni A
AD  - Elettra-Sincrotrone Trieste, Area Science Park, S.S. 14, km 163.5, 34149, 
      Trieste, Italy.
FAU - Scaini, Denis
AU  - Scaini D
AUID- ORCID: 0000-0001-8398-8074
AD  - Neurobiology Sector, International School for Advanced Studies (SISSA/ISAS), Via 
      Bonomea 265, 34136, Trieste, Italy.
AD  - Elettra-Sincrotrone Trieste, Area Science Park, S.S. 14, km 163.5, 34149, 
      Trieste, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190325
PL  - Germany
TA  - Adv Biosyst
JT  - Advanced biosystems
JID - 101711718
RN  - 0 (Nanotubes, Carbon)
SB  - IM
MH  - Animals
MH  - *Brain-Computer Interfaces
MH  - Hippocampus/cytology/*metabolism
MH  - *Nanotubes, Carbon
MH  - Nerve Net/cytology/*metabolism
MH  - Neurons/cytology/*metabolism
MH  - Rats
OTO - NOTNLM
OT  - CVD
OT  - carbon nanotubes
OT  - electrical activity
OT  - neuronal network
OT  - surface patterning
EDAT- 2019/05/01 00:00
MHDA- 2020/09/25 06:00
CRDT- 2020/07/07 06:00
PHST- 2018/10/10 00:00 [received]
PHST- 2019/02/28 00:00 [revised]
PHST- 2020/07/07 06:00 [entrez]
PHST- 2019/05/01 00:00 [pubmed]
PHST- 2020/09/25 06:00 [medline]
AID - 10.1002/adbi.201800286 [doi]
PST - ppublish
SO  - Adv Biosyst. 2019 May;3(5):e1800286. doi: 10.1002/adbi.201800286. Epub 2019 Mar 
      25.