PMID- 32627456
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20200917
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 45
IP  - 12
DP  - 2020 Jun
TI  - [Research progress on anti-atherosclerosis effect and mechanism of flavonoids 
      compounds mediated by macrophages].
PG  - 2827-2834
LID - 10.19540/j.cnki.cjcmm.20200119.403 [doi]
AB  - Flavonoids are important active ingredients of traditional Chinese medicine, 
      mainly with cardiovascular, anti-liver injury, antioxidant, antispasmodic, and 
      estrogen-like effects. These compounds have obvious effects on the cardiovascular 
      and cerebrovascular diseases. Macrophage-derived foam cells are the key medium in 
      the process of atherosclerosis(AS). In plaque, allserum lipids, serum 
      lipoproteins, and various pro-or anti-inflammatory stimulating factors, 
      chemokines, and small bioactive molecules can significantly affect the macrophage 
      phenotype and induce stronger pro-inflammatory or anti-inflammatory properties. 
      Studies have shown that some flavonoids can be used for macrophages through 
      different pathways and mechanisms, playing an anti-atherosclerosis effect to 
      different degrees, including promotion of cholesterol efflux from macrophages, 
      anti-foaming of macrophages, inhibition of secretion of inflammatory factors, and 
      antioxidant modified low density lipoprotein(ox-LDL)-induced apoptosis of 
      macrophages. Related gene regulation inclu-ded ATP-binding cassette transporter 
      A1(ABCA1), ATP-binding cassette transporter G1(ABCG1), Toll-like receptor(TLR), 
      and scavenger receptor(SR). In this article, we would review the recent research 
      progress of flavonoids on anti-atherosclerosis effect me-diated by macrophage. It 
      is expected to provide new treatment strategies for AS-related cardiovascular and 
      cerebrovascular diseases, and provide research ideas and development directions 
      for the use of related natural medicines and design of new products.
FAU - Li, Hong
AU  - Li H
AD  - Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese 
      Medicine Nanning 530200, China Guangxi Key Laboratory of Zhuang and Yao Ethnic 
      Medicine Nanning 530200, China.
FAU - Bai, Lu
AU  - Bai L
AD  - Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese 
      Medicine Nanning 530200, China.
FAU - Qin, Qin
AU  - Qin Q
AD  - Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese 
      Medicine Nanning 530200, China.
FAU - Feng, Bo-Lin
AU  - Feng BL
AD  - Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese 
      Medicine Nanning 530200, China.
FAU - Zhang, Liang
AU  - Zhang L
AD  - Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese 
      Medicine Nanning 530200, China.
FAU - Wei, Fei-Yan
AU  - Wei FY
AD  - Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese 
      Medicine Nanning 530200, China.
FAU - Yang, Xiu-Fen
AU  - Yang XF
AD  - Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese 
      Medicine Nanning 530200, China Guangxi Key Laboratory of Zhuang and Yao Ethnic 
      Medicine Nanning 530200, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (Flavonoids)
RN  - 0 (Lipoproteins, LDL)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - ATP Binding Cassette Transporter 1
MH  - *Atherosclerosis
MH  - Cholesterol
MH  - *Flavonoids
MH  - Foam Cells
MH  - Humans
MH  - Lipoproteins, LDL
MH  - Macrophages
OTO - NOTNLM
OT  - anti-atherosclerosis
OT  - flavonoids
OT  - macrophages
EDAT- 2020/07/07 06:00
MHDA- 2020/09/18 06:00
CRDT- 2020/07/07 06:00
PHST- 2020/07/07 06:00 [entrez]
PHST- 2020/07/07 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20200119.403 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(12):2827-2834. doi: 
      10.19540/j.cnki.cjcmm.20200119.403.