PMID- 32629878
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 7
DP  - 2020 Jun 30
TI  - Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects.
LID - 10.3390/jcm9072055 [doi]
LID - 2055
AB  - BACKGROUND: Type 2 diabetes (T2D) is correlated to amnestic mild cognitive 
      impairment (aMCI) and to non-amnestic mild cognitive impairment (naMCI). This 
      study evaluated whether the T2D variable characterizes a peculiar cognitive 
      profile in elderly patients. Moreover, it explores the association between 
      glycated hemoglobin levels (HbA1c), T2D duration, insulin and oral hypoglycemic 
      agent treatment, and cognition in elderly diabetic patients. METHODS: Detailed 
      neuropsychological battery was used to diagnose MCI subtypes. A total of 39 MCI 
      subjects with T2D (T2D-MCI) and 37 MCI subjects without T2D (ND-MCI), matched for 
      age, educational level, and Mini-Mental State Examination score, were included. 
      RESULTS: ND-MCI performed worse in memory and language domains than T2D-MCI. The 
      amnestic subtype is more frequent among ND-MCI and non-amnestic subtype in 
      T2D-MCI. In T2D-MCI, high HbA1c levels correlate with episodic memory (immediate 
      recall) and T2D duration. Some indexes of episodic memory (immediate recall), 
      attention, and visual-spatial ability correlate with insulin treatment. 
      CONCLUSIONS: An association between T2D and non-amnestic MCI is suggested. In the 
      T2D-MCI group, significant associations between insulin treatment and memory 
      (immediate recall), complex figure copy, and attention were found.
FAU - Valenza, Silvia
AU  - Valenza S
AD  - Neurology Department, Italian National Research Center on Aging (IRCCS INRCA), 
      60100 Ancona, Italy.
AD  - Psychology Department, Azienda Ospedaliera Ospedali Riuniti Marche Nord, 61121 
      Pesaro-Fano, Italy.
FAU - Paciaroni, Lucia
AU  - Paciaroni L
AD  - Neurology Department, Italian National Research Center on Aging (IRCCS INRCA), 
      60100 Ancona, Italy.
FAU - Paolini, Susy
AU  - Paolini S
AD  - Neurology Department, Italian National Research Center on Aging (IRCCS INRCA), 
      60100 Ancona, Italy.
FAU - Bonfigli, Anna Rita
AU  - Bonfigli AR
AUID- ORCID: 0000-0002-9619-0181
AD  - Scientific Direction, Italian National Research Center on Aging (IRCCS INRCA), 
      60100 Ancona, Italy.
FAU - Di Rosa, Mirko
AU  - Di Rosa M
AUID- ORCID: 0000-0002-1862-4159
AD  - Unit of Geriatric Pharmacoepidemiology and Biostatistics, Italian National 
      Research Center on Aging (IRCCS INRCA), 60124 Ancona, Italy.
FAU - Rabini, Rosa Anna
AU  - Rabini RA
AD  - Metabolic Diseases and Diabetology Department, Italian National Research Center 
      on Aging (IRCCS INRCA), 60100 Ancona, Italy.
FAU - Tortato, Elena
AU  - Tortato E
AD  - Metabolic Diseases and Diabetology Department, Italian National Research Center 
      on Aging (IRCCS INRCA), 60100 Ancona, Italy.
FAU - Pelliccioni, Paolo
AU  - Pelliccioni P
AUID- ORCID: 0000-0002-6024-0183
AD  - Eye Clinic, Polytechnic University of Marche, 60126 Ancona, Italy.
FAU - Pelliccioni, Giuseppe
AU  - Pelliccioni G
AUID- ORCID: 0000-0002-0377-9713
AD  - Neurology Department, Italian National Research Center on Aging (IRCCS INRCA), 
      60100 Ancona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200630
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7408775
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - aging
OT  - cognitive functions
OT  - dementia
OT  - mild cognitive impairment
OT  - neuropsychological test
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/08 06:00
MHDA- 2020/07/08 06:01
PMCR- 2020/06/30
CRDT- 2020/07/08 06:00
PHST- 2020/05/11 00:00 [received]
PHST- 2020/06/09 00:00 [revised]
PHST- 2020/06/24 00:00 [accepted]
PHST- 2020/07/08 06:00 [entrez]
PHST- 2020/07/08 06:00 [pubmed]
PHST- 2020/07/08 06:01 [medline]
PHST- 2020/06/30 00:00 [pmc-release]
AID - jcm9072055 [pii]
AID - jcm-09-02055 [pii]
AID - 10.3390/jcm9072055 [doi]
PST - epublish
SO  - J Clin Med. 2020 Jun 30;9(7):2055. doi: 10.3390/jcm9072055.