PMID- 32629985
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 10
IP  - 7
DP  - 2020 Jun 30
TI  - Ultrasound Stimulation Increases Neurite Regeneration in Injured Dorsal Root 
      Ganglion Neurons through Mammalian Target of Rapamycin Activation.
LID - 10.3390/brainsci10070409 [doi]
LID - 409
AB  - Ultrasound stimulation (US) is reported to be a safe and useful technology for 
      improving injured nerve regeneration. However, the intracellular mechanisms 
      underlying its stimulatory effects are only partially understood. Mammalian 
      target of rapamycin (mTOR) signaling is involved in neuronal survival and axonal 
      outgrowth. In this study, we investigated the effect of US on regeneration of 
      injured dorsal root ganglion (DRG) neurons and activation of the mTOR pathway. We 
      showed that US significantly increased neurite regeneration and enhanced mTOR 
      activation. Moreover, the expression of growth-associated protein-43 (GAP-43), a 
      crucial factor for axonal outgrowth and regeneration in neurons, was 
      significantly increased by US. These data suggest that US-induced neurite 
      regeneration is mediated by upregulation of mTOR activity, which promotes the 
      regeneration of injured DRG neurons.
FAU - Han, Sungmin
AU  - Han S
AUID- ORCID: 0000-0003-2762-668X
AD  - Biomedical Research Institute, Korea Institute of Science and Technology, 5, 
      Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Korea.
FAU - Park, Jinyoung
AU  - Park J
AD  - Molecular Recognition Research Center, Korea Institute of Science and Technology, 
      Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Korea.
FAU - Choi, Won Seok
AU  - Choi WS
AD  - Biomedical Research Institute, Korea Institute of Science and Technology, 5, 
      Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Korea.
FAU - Youn, Inchan
AU  - Youn I
AD  - Biomedical Research Institute, Korea Institute of Science and Technology, 5, 
      Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Korea.
AD  - Division of Bio-Medical Science &Technology, KIST School, Korea University of 
      Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Korea.
LA  - eng
GR  - CAP-18-01-KIST/National Research Council of Science and Technology/
PT  - Journal Article
DEP - 20200630
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC7407506
OTO - NOTNLM
OT  - dorsal root ganglion
OT  - mammalian target of rapamycin
OT  - neurite regeneration
OT  - ultrasound stimulation
COIS- The authors declare no conflicts of interest.
EDAT- 2020/07/08 06:00
MHDA- 2020/07/08 06:01
PMCR- 2020/07/01
CRDT- 2020/07/08 06:00
PHST- 2020/06/02 00:00 [received]
PHST- 2020/06/23 00:00 [revised]
PHST- 2020/06/30 00:00 [accepted]
PHST- 2020/07/08 06:00 [entrez]
PHST- 2020/07/08 06:00 [pubmed]
PHST- 2020/07/08 06:01 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - brainsci10070409 [pii]
AID - brainsci-10-00409 [pii]
AID - 10.3390/brainsci10070409 [doi]
PST - epublish
SO  - Brain Sci. 2020 Jun 30;10(7):409. doi: 10.3390/brainsci10070409.